Onychomycosis (Tinea Unguium)

09/01/2004 - "The accepted regimen for terbinafine, one of the most effective treatments for dermatophyte onychomycosis, is continuous administration of 250 mg/day over 16 weeks. "
02/15/2001 - "Continuous oral terbinafine therapy is most effective against dermatophytes, which are responsible for the majority of onychomycosis cases. "
01/01/2000 - "With regard to continuous oral antifungal regimens, terbinafine therapy has been found to be most cost effective in the treatment of toenail onychomycosis, with a drug acquisition cost of $US522.50. "
10/01/2009 - "Terbinafine is an excellent choice in diabetics due to its low risk of drug-drug interaction and proven efficacy against the typical pathogens that cause onychomycosis. "
06/01/2010 - "The pharmacologic and pharmacokinetic properties of terbinafine give strong support to the possibility that the pulse therapy may be equally effective in onychomycoses, possibly reducing medication costs and drug exposure. "

12/01/1998 - "In conclusion, intermittent itraconazole therapy is highly effective and safe in patients with onychomycosis."
12/01/2012 - "The purpose of the present study was to design and evaluate the potential of microemulsion-based gel as colloidal carrier for itraconazole for delivery into onycholytic nails for effective treatment of onychomycosis. "
10/01/2009 - "Itraconazole, while an effective treatment for onychomycosis, is not a first-choice therapy due to its black-box cardiac warning and numerous drug interactions. "
09/01/2005 - "Itraconazole may be effective in the treatment of onychomycosis caused by F. "
11/01/2003 - "Itraconazole was found to be effective, well-tolerated and safe therapy for disto-lateral subungual onychomycosis."

03/01/2006 - "Congenital candidal onychomycoses: effective cure with ciclopirox olamine 8% nail lacquer."
10/01/2000 - "Data from the pivotal US trials have demonstrated that ciclopirox nail lacquer 8% topical solution is significantly more effective than placebo in the treatment of onychomycosis caused by Trichophyton rubrum, and of mild to moderate toe onychomycosis without lunula involvement. "
09/01/1991 - "This study indicates that 8% ciclopirox olamine nail liquor, with its satisfactory efficacy and lack of side effects, is a good remedy for onychomycosis."
08/01/2001 - "We report the case of a 75-year-old man with moderate-to-severe onychomycosis who was treated successfully with ciclopirox nail lacquer solution 8%, the first topical antifungal agent approved by the Food and Drug Administration for the treatment of this disease."
10/01/2000 - "Ciclopirox nail lacquer solution 8% has been shown to be effective in the treatment of dermatophyte onychomycosis of mild to moderate severity Other studies report the effectiveness of ciclopirox nail lacquer in onychomycosis caused by Candida sp and nondermatophyte molds. "

02/01/1995 - "More than half of the cases with onychomycosis in their fingers showed improvement within four weeks and complete recovery within 20 weeks after the administration of fluconazole. "
06/01/1998 - "Preliminary clinical data suggest that fluconazole is effective in the treatment of patients with onychomycosis. "
05/01/1996 - "These results indicate that fluconazole should be effective in the treatment of onychomycosis in a dose of 150 mg once weekly. "
06/01/1998 - "Fluconazole administered once weekly is safe and effective in eradicating distal subungual onychomycosis of the fingernail caused by dermatophytes."
06/01/1998 - "Determinations of plasma and fingernail concentrations of fluconazole were performed as part of a larger study comparing the safety and efficacy of once-weekly fluconazole (150, 300, and 450 mg) to placebo in the treatment of distal subungual onychomycosis of the fingernails caused by dermatophytes. "

11/01/2014 - "Case of infantile onychomycosis successfully cured by 5% amorolfine nail lacquer."
10/01/2015 - "Topical 30% resin lacquer and topical 5% amorolfine lacquer provided similar efficacy for treating dermatophyte toenail onychomycosis. "
08/01/2010 - "Efficacy of amorolfine nail lacquer for the prophylaxis of onychomycosis over 3 years."
10/01/2001 - "These results indicate that amorolfine combination therapy represents an improved treatment strategy for patients with severe onychomycosis."
01/01/1995 - "In clinical trials, application of amorolfine 5% nail lacquer once or twice weekly for up to 6 months produced mycological and clinical cure in approximately 40 to 55% of patients with mild onychomycosis 3 months after cessation of therapy. "

02/01/1987 - "To authenticate the advantage of the etiologic diagnosis of Tinea unguium by mycological studies, the promising result of our previous clinical therapeutic trial with Griseofulvin was presented."
12/15/1966 - "[Catamnesic studies on griseofulvin therapy of onychomycosis]."
04/14/1965 - "[Clinical and mycological studies of griseofulvin treated onychomycoses]."
10/01/1960 - "The results of the study indicated that surgical avulsion of the toenails in combination with griseofulvin therapy is an effective and practical method of treating onychomycosis of the toenails due to T. "
01/01/2012 - "Therefore, the treatment of onychomycosis with griseofulvin seems futile. "

01/01/2004 - "Antifungal agents are beneficial in the treatment of onychomycosis in the general population, as well as in children, the elderly, and immunocompromised individuals. "
02/15/2001 - "With careful monitoring, patients treated with the newer antifungal agents have a good chance of achieving relief from onychomycosis and its complications."
07/01/2011 - "We therefore suggest that we have established an in vivo model of onychomycosis that is useful for the evaluation of the efficacy of antifungal agents."
09/01/2004 - "Despite the relevant increase in clinical trials on the efficacy of various systemic and/or topical antifungal agents in onychomycosis therapy, the evaluation of the results is largely subjective. "
01/01/2004 - "We searched MedLine (1966 to April 2003) for clinical studies evaluating the efficacy of oral and topical antifungal agents to treat onychomycosis. "

02/01/2006 - "Urea is commonly used as a keratolytic substance in the treatment of onychomycoses to improve the penetration of antifungal drugs in the lesion sites. "
12/01/2002 - "The urea nail lacquer was applied with a brush twice a day for 1 week by the patient and for a further week in two patients presenting total dystrophic onychomycosis. "
12/01/2002 - "A new formulation was used as a nail lacquer containing 40% urea in a film-forming solution in 10 patients presenting with onychomycosis. "
08/31/1989 - "Fungus-infected nail material in onychomycoses can be very well removed with a combination of 1% Bifonazol and 40% urea cream, thus eliminating other methods of treatment. "
01/01/1986 - "Urea plaster for softening diseased nails in the treatment of tinea unguium."

01/01/1984 - "Ketoconazole is an effective treatment for onychomycosis: it is active against the different mycotic agents infecting nails and well tolerated by the patient. "
09/10/2004 - "The purpose of this investigation was to study the physico-chemical properties of hot-melt extruded films containing ketoconazole and to determine the influence of 'nail etching' on film bioadhesion and drug permeability for the assessment of topical onychomycosis therapies. "
11/18/2013 - "These results suggest that this novel ketoconazole lacquer has the potential to be an effective topical treatment for onychomycosis. "
09/01/2011 - "Topical OLEOZON(®) demonstrated effectiveness in the treatment of onychomycosis, superior to that of ketoconazole. "
01/01/1997 - "Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study."

01/01/1993 - "The combination of antifungals with active products, such as keratoplastics, is used mainly for the treatment of onychomycoses; 40% urea associated with 1% bifonazole has shown high efficacy for this indication."
07/01/2000 - "We concluded that a two-phase treatment with bifonazole-urea is effective and safe, and represents a new therapeutic choice for onychomycosis in children."
07/01/2013 - "Efficacy of 4 weeks topical bifonazole treatment for onychomycosis after nail ablation with 40% urea: a double-blind, randomized, placebo-controlled multicenter study."
07/01/2000 - "We assessed the safety and efficacy of a two-phase topical treatment with bifonazole-urea ointment in children with onychomycosis. "
04/01/1990 - "A clinical trial has been conducted to assess the efficacy of 1% bifonazole and 40% urea ointment for 2 weeks followed by 1% bifonazole cream for one month in the topical treatment of onychomycosis. "

09/01/2012 - "Long pulse Nd:YAG 1064-nm laser was effective for onychomycosis. "
11/01/2013 - "Laser technology may be a promising new treatment option for onychomycosis. "
01/01/2015 - "Laser-based devices have been approved for the temporary clearance of nails with onychomycosis, thus providing a means of improving the aesthetic appearance of the nails. "
10/01/2013 - "Laser treatment has emerged as a novel treatment modality for onychomycosis. "
10/01/2014 - "The objective of this study was to compare the efficacy of long-pulsed Nd:YAG 1064 nm laser for treatment of toenails onychomycosis with fingernails onychomycosis. "

12/01/2014 - "The 1,320-nm Nd:YAG laser may be a safe and effective therapy for improving the appearance of onychomycosis. "
08/01/2014 - "Our results demonstrate that the 1,064-nm long-pulsed Nd:YAG laser could be a safe and effective treatment modality in the management of patients with onychomycosis."
04/01/2014 - "Nd:YAG lasers could be a safe and effective treatment modality for onychomycosis, without the side effects of drugs. "
10/01/2014 - "Comparison of the efficacy of long-pulsed Nd:YAG laser intervention for treatment of onychomycosis of toenails or fingernails."
10/01/2013 - "We here demonstrate the efficacy of the Nd:YAG laser in the treatment of onychomycosis. "

01/01/2015 - "It has proven through several Phase II and III trials that it can be a safe and effective topical agent for the treatment of mild to moderate toenail onychomycosis without the need for debridement. "
05/01/2009 - "Efficacy of debridement alone versus debridement combined with topical antifungal nail lacquer for the treatment of pedal onychomycosis: a randomized, controlled trial."
01/01/2015 - "Efinaconazole 10% solution is a new topical triazole treatment for mild to moderate distal subungual onychomycosis, with good efficacy and without the need for debridement of nails. "
09/01/2013 - "Onychomycosis treatments include nail avulsion and debridement by chemical or surgical procedures, topical and oral antifungals, and device-based therapies. "
04/01/2008 - "The authors report a pilot study of a new approach for the topical treatment of onychomycosis using physiologic principles of fungal growth and serial debridement. "

11/01/2013 - "Laser therapy offers a safe and effective new option for onychomycosis. "
04/01/2012 - "Recently introduced laser therapy has shown to be a safe and effective treatment for onychomycosis. "
01/01/2014 - "Currently there is a lack of data concerning the long-term efficacy of laser therapy of onychomycosis; certified treatment protocols are needed. "
05/01/2015 - "For laser therapy of onychomycosis, only a few studies on clinical efficacy are available. "
01/01/2015 - "This study will be the first double-blind study that investigates the effects of local laser therapy on onychomycosis, specifically performed in patients with diabetes with additional risk factors for foot complications. "

09/01/2013 - "In this work, we present a case of onychomycosis that was completely cured by using the porphyrin-photodynamic therapy. "
03/01/2010 - "Photodynamic therapy for distal and lateral subungual toenail onychomycosis caused by Trichophyton rubrum: Preliminary results of a single-centre open trial."
07/01/2015 - "An update on photodynamic therapies in the treatment of onychomycosis."
06/01/2015 - "Development and comparison of two devices for treatment of onychomycosis by photodynamic therapy."
03/01/2014 - "canis onychomycosis with photodynamic therapy and a rare case of M. "