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Timolol (Blocadren)

A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.

Also Known As:

Blocadren; Timoptic; (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol; L-714,465; MK-950; Optimol; Timacar; Timolol Hemihydrate; Timolol Maleate; Timolol Maleate, (1:1) Salt; Timoptol; Hemihydrate, Timolol; L 714,465; L714,465; MK 950; MK950; 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-

Networked: 1594 relevant articles (206 outcomes, 361 trials/studies)

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Drug Context: Research Results

Experts

1.	Stewart, William C: 21 articles (01/2013 - 05/2002)
2.	Stewart, W C: 19 articles (10/2010 - 02/2000)
3.	Stewart, Jeanette A: 14 articles (01/2013 - 05/2002)
4.	Konstas, Anastasios G P: 13 articles (06/2014 - 06/2002)
5.	Holló, Gábor: 12 articles (07/2015 - 06/2008)
6.	Harris, Alon: 10 articles (01/2013 - 03/2002)
7.	Araie, Makoto: 9 articles (07/2015 - 03/2003)
8.	Ropo, Auli: 9 articles (01/2015 - 07/2005)
9.	Siesky, Brent: 9 articles (01/2013 - 03/2002)
10.	Konstas, A G P: 9 articles (01/2012 - 01/2003)

Related Diseases

1.	Ocular Hypertension (Glaucoma, Suspect) 10/01/2011 - "Topical timolol maleate is an effective treatment for ocular hypertension, acting by reducing aqueous fluid production. " 01/01/1989 - "A 5-year, randomized, double-masked, clinical trial was conducted to determine whether treatment with topical timolol maleate was effective in preventing or delaying the onset of glaucomatous visual field loss in subjects with ocular hypertension. " 04/01/2005 - "In the Malmö Ocular Hypertension Study, 90 patients were randomized to topical timolol or placebo treatment and observed prospectively for up to 10 years. " 11/01/2001 - "In agreement with other masked and controlled studies and in conflict with uncontrolled ones, the present study did not demonstrate long-term drift of intraocular pressure in patients with ocular hypertension treated with topical timolol." 11/01/2000 - "Long-term effects of timolol therapy in ocular hypertension: a double-masked, randomised trial."
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 09/01/1979 - "Timolol maleate appears to be effective and well tolerated when administered with other antiglaucoma medications in patients with open-angle glaucoma." 10/01/2005 - "The aim of this study was to determine the effectiveness of timolol gel-forming solution as a monotherapy and to compare the efficacy of timolol gel-forming solution morning instillation versus at night application in Asians with newly diagnosed open-angle glaucoma. " 10/01/2012 - "The study was undertaken to measure the effects of Beta blocker (Timolol maleate 0.5%) in moderate and advanced stage of primary open angle glaucoma by controlling intra-ocular pressure (IOP) and assessing the visual acuity (VA) and mean sensitivity (MS) of visual field. " 10/01/2009 - "Twenty-five patients with primary open-angle glaucoma (POAG) who were treated with topical timolol 0.5% were included in the study. " 03/01/2009 - "The study included 40 patients (80 eyes) with open angle glaucoma and intraocular pressure (IOP) above 18 mm Hg treated with topical beta blocker (timolol 0.50% twice a day). "
3.	Glaucoma 05/01/2002 - "Evidence of the presence of a new metabolite is important from the aspect of understanding and more accurate definition of the action of Timoptol in tissue structures of the eye and thus also for possible effective treatment of glaucoma." 01/01/1987 - "Since D-timolol is effective in reducing intraocular pressure, these results indicate that D-timolol is superior to L-timolol for glaucoma treatment. " 08/01/1983 - "A group of 130 patients with chronic glaucoma has been followed from one to more than three years on timolol maleate drops; this confirms that these drops remain effective in long-term therapy through added therapy is usually needed. " 11/01/2013 - "Timolol is an effective and safe medication that is widely used in glaucoma treatment. " 08/01/1985 - "Thirty-one eyes (78%) in this group had a pressure drop; 18 eyes (45%) had a pressure drop of greater than 10 mm Hg. We conclude that timolol is effective in the treatment of pediatric glaucoma, although there is a need to be aware of its potential complications."
4.	Hemangioma (Angioma) 08/01/2015 - "Topical beta-blockers such as timolol appear to be effective in treating small, superficial infantile hemangiomas. " 03/01/2012 - "The treatment outcome of our cases indicates that timolol gel is well-tolerated and effective for the therapy for infantile hemangioma. " 04/01/2015 - "Timolol has recently been reported to be an effective and safe treatment for small and superficial infantile hemangiomas (IH). " 06/01/2013 - "Timolol maleate 0.5% gel is a safe and effective medication for treating superficial infantile hemangiomas (IHs) in infants with a median age of 9 weeks. " 05/01/2012 - "Topical timolol is effective and safe in the treatment of superficial periocular infantile hemangioma. "
5.	Hypertension (High Blood Pressure) 12/01/1981 - "Thus, timolol is effective in reducing mild high blood pressure during short-term therapy and in maintaining this effect over the long term in responsive subjects. " 11/01/1981 - "Timolol, a nonselective beta-adrenoreceptor blocking agent without intrinsic sympathomimetic or membrane stabilizing activity, has been shown effective in the treatment of angina and hypertension. " 01/01/1985 - "The value of home blood pressure monitoring in the assessment of the efficacy of timolol in the management of hypertension." 03/01/1984 - "The present study measured the hemodynamics of the initial hypotensive action of timolol maleate, a nonselective beta-adrenoreceptor blocking agent, in 10 patients with essential hypertension. " 04/01/1980 - "Nine previously untreated patients with mild-moderate hypertension were included in a dose-ranging double-blind trial to determine the effectiveness of daily versus thrice daily timolol administration. "

Related Drugs and Biologics

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3.	travoprost (Travatan)
4.	brinzolamide (Azopt)
5.	brimonidine (Alphagan)
6.	bimatoprost (Lumigan)
7.	Pilocarpine (Ocusert)
8.	Propranolol (Inderal)
9.	Levobunolol (AKBeta)
10.	Timolol (Blocadren)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Trabeculectomy (Trabeculoplasty)
3.	Phacoemulsification
4.	Aftercare (After-Treatment)
5.	Topical Administration