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Ticarcillin (Tarcil)

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An antibiotic derived from penicillin similar to CARBENICILLIN in action.

Also Known As:

Tarcil; Ticar; BRL-2288; CSL Brand of Ticarcillin Disodium; GlaxoSmithKline Brand of Ticarcillin Disodium; GlaxoSmithKline Brand of Ticarcillin Disodium Salt; SmithKline Beecham Brand of Ticarcillin Disodium; SmithKline Beecham Brand of Ticarcillin Disodium Salt; Ticarcillin Disodium; Ticarpen; Ticillin; BRL 2288; BRL2288; Disodium, Ticarcillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-

Networked: 421 relevant articles (63 outcomes, 88 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Zobell, Jeffery T: 3 articles (03/2014 - 07/2010)
2.	Young, David C: 2 articles (03/2014 - 11/2011)
3.	Korgenski, Kent: 2 articles (11/2011 - 07/2010)
4.	Ampofo, Krow: 2 articles (11/2011 - 07/2010)
5.	Chatfield, Barbara A: 2 articles (11/2011 - 07/2010)
6.	Cash, Jared: 2 articles (11/2011 - 07/2010)
7.	Karabak, V I: 2 articles (01/2000 - 01/2000)
8.	Sadikot, Ruxana T: 1 article (02/2015)
9.	Swenson, Colin E: 1 article (02/2015)
10.	Lemieux, Pierre: 1 article (01/2015)

Related Diseases

1.	Infection 11/01/1978 - "Our study suggests that ticarcillin is useful in the treatment of anaerobic infections." 12/01/1999 - "[Molecular study of a false outbreak of ticarcillin-resistant Pseudomonas aeruginosa infections in a clinical hematology department]." 01/01/2012 - "Our data suggested that cationic ticarcillin-loaded nanoliposomes because of high effectiveness would be a good choice to treatment of Pseudomonas aeruginosa infections." 11/01/2002 - "We compared the antibiotic effects of ticarcillin administered in various doses and dosing regimens against Pseudomonas aeruginosa ATCC 27853 under conditions analogous to those previously employed in a neutropenic-mouse thigh infection model (B. " 10/01/2001 - "Obviously unbalanced comparative studies showed some benefit of ticarcillin for bone infections caused by Pseudomonas species. "
2.	Cystic Fibrosis (Mucoviscidosis) 01/01/1990 - "The nonrenal clearance of ticarcillin was also significantly higher in patients with cystic fibrosis (24.8 +/- 11.1 versus 13.3 +/- 6.0 ml/min/m2 for the control group; p = 0.006). " 01/01/1990 - "The total body clearance of ticarcillin was significantly higher in cystic fibrosis patients (65.6 +/- 22.0 versus 46.2 +/- 10.9 ml/min/m2 in control subjects; p = 0.017). " 01/01/1990 - "We concluded that the shorter elimination half-life and the higher total body clearance of ticarcillin in patients with cystic fibrosis are a result of an increase in both renal and nonrenal elimination." 06/01/2000 - "Forty-five percent of the non-cystic fibrosis strains presented intermediate susceptibility or resistance to ticarcillin. " 11/01/1993 - "Nebulized ticarcillin can cause bronchoconstriction in children with cystic fibrosis (CF). "
3.	Neoplasms (Cancer) 07/01/1973 - "Clinical pharmacological studies of ticarcillin (alpha-carboxyl-3-thienylmethyl penicillin, BRL-2288) were conducted in patients with metastatic cancer and leukemia. " 01/01/1981 - "These data suggest that the combination of amikacin and ticarcillin is an effective and safe empiric regimen in febrile children with cancer." 01/01/1981 - "Efficacy of amikacin and ticarcillin as empiric therapy in febrile neutropenic children with cancer." 06/01/1987 - "Efficacy and safety of azlocillin and ticarcillin in febrile neutropenic children with cancer: a comparative study." 03/01/1987 - "Eighty-one febrile episodes in cancer patients with adequate neutrophil counts (greater than 1000/microliter) were treated with a double beta-lactam combination of ceftizoxime plus ticarcillin. "
4.	Endometritis 07/01/1984 - "Ticarcillin appears to be effective in reducing the incidence of postcesarean endomyometritis in adolescent patients. " 07/01/1984 - "The patients who received prophylactic ticarcillin had one-half the endomyometritis rate as the placebo group. " 06/01/1982 - "Among the 139 patients who received ticarcillin, endomyometritis developed in 44 (32%), as it did in 66 of 120 patients (55%) in the placebo group. " 06/01/1982 - "Ticarcillin appears to be effective in reducing the incidence of post-cesarean section endomyometritis in patients at high risk and in those at low risk. " 06/01/1982 - "The efficacy of ticarcillin in the prevention of post-cesarean section endomyometritis was studied in 259 women randomly given either the antibiotic or a placebo. "
5.	Pneumonia (Pneumonitis) 11/29/1985 - "The combination of ticarcillin and clavulanic acid is safe and effective therapy for pneumonia in anatomically compromised hosts." 01/01/2000 - "Efficacy of ticarcillin/clavulanate was studied in the treatment of 11 patients with severe community- and hospital-acquired pneumonia in an open controlled trial. " 01/01/2000 - "[The clinical efficacy of ticarcillin/clavulanate in severe pneumonia]." 01/01/2000 - "It is concluded that ticarcillin/clavulanate is highly efficient in the treatment of patients with severe or complicated pneumonia. " 11/01/1989 - "Aerosolized tobramycin was given to a 68-year-old man with resistant Pseudomonas aeruginosa pneumonitis at a dose of 100 mg every 8 h via a tracheostomy, after the patient failed to respond adequately to parenteral aminoglycoside and ticarcillin therapy. "

Related Drugs and Biologics

1.	Clavulanic Acid (Potassium Clavulanate)
2.	Gentamicins (Gentamicin)
3.	Clindamycin (Cleocin)
4.	Tobramycin (Nebcin)
5.	Azlocillin (Azlin)
6.	Carbenicillin (Pyopen)
7.	Amikacin (A.M.K)
8.	ticarcillin-clavulanic acid (Timentin)
9.	Ceftazidime (Fortum)
10.	beta-Lactamases (beta-Lactamase)

Related Therapies and Procedures

1.	Cesarean Section (Caesarean Section)
2.	Drug Therapy (Chemotherapy)
3.	Transplants (Transplant)
4.	Tonsillectomy
5.	Subcutaneous Injections