Thyrotropin (Thyroid-Stimulating Hormone)

A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.

Also Known As:

Networked: 4799 relevant articles (103 outcomes, 343 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hegedüs, Laszlo: 15 articles (09/2014 - 12/2003)
2.	Marte, Filippo: 14 articles (04/2012 - 05/2009)
3.	Patanè, Salvatore: 14 articles (04/2012 - 05/2009)
4.	Völzke, Henry: 13 articles (06/2015 - 07/2006)
5.	Jonklaas, Jacqueline: 12 articles (01/2016 - 02/2008)
6.	Rodondi, Nicolas: 12 articles (06/2015 - 11/2005)
7.	Braverman, Lewis E: 11 articles (11/2014 - 07/2002)
8.	Wartofsky, Leonard: 11 articles (10/2013 - 07/2002)
9.	Tuttle, R Michael: 10 articles (12/2015 - 07/2002)
10.	Pacini, Furio: 10 articles (07/2014 - 09/2002)

Related Diseases

1.	Hypothyroidism 10/01/2010 - "Improved diagnosis of mild hypothyroidism using time-of-day normal ranges for thyrotropin." 03/01/2010 - "Exogenous stimulation of thyroid-stimulating hormone (TSH) using recombinant human TSH (rhTSH) avoids hypothyroidism and hastens the clearance of radioiodine from the patient. " 07/01/2006 - "Bovine thyrotropin (bTSH) stimulation testing has long been considered the gold standard for diagnosis of canine hypothyroidism. " 01/01/2002 - "In three of the patients, l-T4 administration could be discontinued and the clinical symptoms of hypothyroidism disappeared because of an improved serum thyroid-stimulating hormone level. " 04/01/1999 - "The gold standard for diagnosis of hypothyroidism remains the thyroid-stimulating hormone response test. "
2.	Thyroid Neoplasms (Thyroid Cancer) 06/01/2015 - "Postoperative radioiodine remnant ablation and strict suppression of serum thyrotropin, although effective for the more aggressive forms of thyroid cancer, have not been shown to be beneficial for the treatment of low risk patients, and may impair their quality of life. " 08/01/2014 - "The aim of this study was to evaluate the efficacy of post-operative radioiodine ablation with 1,850 MBq after recombinant human thyrotropin (rhTSH) administration in patients with differentiated thyroid carcinoma (DTC). " 04/01/2005 - "Recombinant human thyrotropin is helpful in the follow-up and 131I therapy of patients with thyroid cancer: a report of the results and benefits using recombinant human thyrotropin in clinical routine." 01/01/2016 - "Several recent studies have illuminated our understanding of the benefits and risks of thyrotropin suppression therapy in patients with differentiated thyroid cancer. " 07/01/2014 - "The aim of this study was to evaluate the effect of recombinant human thyroid stimulating hormone (rhTSH) on sustaining liver and renal function in thyroid cancer patients during radioiodine therapy (RIT). "
3.	Neoplasms (Cancer) 07/02/1987 - "Serum levels of thyrotropin were dramatically reduced by treatment in four of the five patients, and levels of another tumor marker, the alpha-subunit of thyrotropin, were reduced in all five. " 09/01/2013 - "The objective of the study was to investigate whether metabolic tumor volume (MTV) measured by fluorine-18 fluorodeoxyglucose (F-FDG) PET/computed tomography (PET/CT) after stratification of serum thyroid stimulating hormone (TSH) levels could predict malignancy in patients with thyroid F-FDG incidentaloma. " 03/01/2013 - "In the last 6 years, several studies reported a positive association between thyrotropin (TSH) and papillary cancer risk. " 01/01/2012 - "The aim of the study is to determine if thyrotropin is a predictive factor for a malignant nature of follicular neoplasm. " 11/01/2015 - "BRAF(V600E) positivity is associated with multifocality after adjusting for age, sex, the presence of suspicious ultrasonographic features, pathological tumor size, and thyrotropin level. "
4.	Hyperthyroidism 04/01/1988 - "We report a prospective multicenter study, undertaken to compare the efficacy of 10 highly sensitive thyrotropin assay kits for the diagnosis of hyperthyroidism. " 08/01/1997 - "In the remission group, to exclude the influence of subclinical hyperthyroidism, thyrotropin (TSH) levels were followed and subjects with low levels excluded. " 08/01/1984 - "In contrast, there is now a large body of work which shows that thyrotrophin receptor antibody levels, central to the aetiology of Graves' hyperthyroidism, fall during antithyroid treatment and that remission may be related to this fall in a fashion which is dependent on the dose and duration of treatment. " 10/01/2006 - "A study population of 4087 subjects (2050 women) without overt hyperthyroidism or increased serum thyrotropin levels was available for the present study. " 09/01/2005 - "To evaluate the prevalence of latent and manifest hyperthyroidism in a non-selected group of patients admitted for contrast enhanced CT studies blood samples were tested for the levels of thyroid-stimulating hormone (TSH). "
5.	Pituitary Neoplasms (Pituitary Adenoma) 11/01/1990 - "Thyrotropin-secreting pituitary adenomas have been diagnosed more frequently as radiographic techniques and biochemical assays have improved; however, they remain uncommon and are unfamiliar to most neurosurgeons. " 08/01/2015 - "The first-choice treatment of thyrotropin (TSH)-secreting pituitary adenomas is surgical adenomectomy, with 40-60% of patients cured after surgery. " 12/01/2014 - "The aim of this study was to analyze clinicopathological characteristics and treatment outcomes in a large single-center clinical series of cases of thyrotropin (TSH)-secreting pituitary adenomas. " 12/01/2014 - "Clinicopathological characteristics and therapeutic outcomes in thyrotropin-secreting pituitary adenomas: a single-center study of 90 cases." 01/01/2014 - "A total of 20 patients with thyrotropin-secreting pituitary adenomas hospitalized in Shanghai Huashan Hospital from 2006 to 2013 were enrolled in the study. "

Related Drugs and Biologics

1.	Thyroxine (Levothyroxine)
2.	Hormones
3.	Octreotide (Sandostatin)
4.	Antibodies
5.	Adrenocorticotropic Hormone (ACTH)
6.	Triiodothyronine (Liothyronine)
7.	Prolactin
8.	Thyrotropin (Thyroid-Stimulating Hormone)
9.	Thyroglobulin
10.	Growth Hormone (Somatotropin)

Related Therapies and Procedures

1.	Thyroidectomy
2.	Aftercare (After-Treatment)
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement)