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Thymus Neoplasms (Thymus Neoplasm)

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Tumors or cancer of the THYMUS GLAND.

Also Known As:

Thymus Neoplasm; Tumor, Thymic; Thymus Tumors; Cancer of the Thymus; Neoplasms, Thymic; Neoplasms, Thymus; Thymic Cancer; Thymic Neoplasms; Thymic Tumors; Cancer, Thymic; Cancer, Thymus; Cancers, Thymic; Cancers, Thymus; Neoplasm, Thymic; Neoplasm, Thymus; Thymic Cancers; Thymic Neoplasm; Thymic Tumor; Thymus Cancers; Thymus Tumor; Tumor, Thymus; Tumors, Thymic; Tumors, Thymus; Cancer of Thymus; Thymus Cancer

Networked: 186 relevant articles (12 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Thymoma (Thymic Carcinoma)
2.	Neoplasms (Cancer)
3.	Myasthenia Gravis
4.	Lymphoma (Lymphomas)
5.	Lung Neoplasms (Lung Cancer)

Experts

1.	Venuta, Federico: 5 articles (04/2015 - 12/2003)
2.	Rendina, Erino A: 3 articles (04/2015 - 12/2003)
3.	van Hagen, P M: 3 articles (02/2015 - 01/2001)
4.	Anile, Marco: 3 articles (08/2014 - 12/2003)
5.	Kaira, Kyoichi: 3 articles (01/2014 - 11/2005)
6.	Wright, Cameron D: 3 articles (02/2011 - 02/2008)
7.	Montella, Liliana: 3 articles (01/2009 - 03/2002)
8.	Palmieri, Giovannella: 3 articles (01/2009 - 03/2002)
9.	Caramanti, Miriam: 2 articles (08/2015 - 05/2014)
10.	Berardi, Rossana: 2 articles (08/2015 - 05/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thymus Neoplasms:

1.	Carboplatin (JM8)FDA LinkGeneric 12/01/2006 - "Intrapericardial administration of carboplatin is a useful therapy for control of pericardial effusion and chemosensitive cases should de identified among patients with thymic cancer." 12/01/2006 - "[Successful treatment of intrapericardial administration of carboplatin following systemic chemotherapy in a case of advanced thymic cancer with cardiac tamponade]." 12/01/2014 - "[A case of thymic cancer effectively treated by weekly paclitaxel combined with carboplatin]." 12/01/2014 - "Weekly paclitaxel combined with carboplatin appears to be a useful regimen with minimal toxicity for advanced thymic cancer." 11/01/2010 - "Carboplatin plus paclitaxel can be an active agent against pretreated thymic cancer."
2.	Octreotide (Sandostatin)FDA LinkGeneric 04/01/2012 - "The objective of this retrospective study was to evaluate the efficacy of long-acting octreotide (Sandostatin LAR) for the treatment of thymic tumors, with a primary efficacy end point of progression-free survival. " 04/01/2012 - "Efficacy and tolerability of long-acting octreotide in the treatment of thymic tumors: results of a pilot trial." 06/01/2010 - "A recent study using octreotide and prednisone in thymic tumors, Eastern Cooperative Oncology Group study E1C97, was conducted to verify the activity of octreotide for thymic tumors. " 05/01/2012 - "[111In-DTPA-D-Phe1]-octreotide scintigraphy allows the visualization of SRIF receptor (SSR)-expressing tumors, including thymic tumors, and normal tissues. " 03/01/2002 - "Evidence of a high uptake of indium-labeled octreotide ((111)In-DTPA-D-Phe(1)-octreotide) in thymic tumors and the curative application of somatostatin analogs and prednisone in one patient with thymoma and pure red cell aplasia led the authors to start a Phase II study. "
3.	Adrenocorticotropic Hormone (ACTH)FDA Link 08/01/1970 - "Ultrastructural studies of an ACTH-secreting thymic tumor." 09/01/1979 - "Addition of rat median eminence extract significantly stimulated ACTH secretion and increased levels of intracellular cAMP in both cell preparations, and a dose-response relationship appeared to exist between the dose of rat median eminence extract added and either ACTH secretion or intracellular cAMP formation in the thymic tumor cells. " 10/01/1976 - "ACTH was purified from thymic tumor associated with ectopic ACTH production by gel filtration and ion exchange chromatography. " 10/01/2011 - "He was evaluated and diagnosed with ectopic Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome due to a thymic tumor. " 04/01/2011 - "Carcinoids are rare thymic tumors, and when associated with ACTH hypersecretion display local or distant aggressive behavior. "
4.	Cisplatin (Platino)FDA LinkGeneric 11/01/2005 - "In inoperable locally advanced, or metastatic thymic tumors, neoadjuvant cisplatin-based followed by surgery and radiotherapy has given interesting results in the past years." 01/01/2005 - "Thymic tumors are chemoresponsive with optimal responses achieved with cisplatin-based combination chemotherapy. " 01/01/2008 - "However when thymic cancers are complicated by paraneoplastic syndromes that damage kidney and neurological function, cisplatin use is often contraindicated. " 02/01/2008 - "Induction therapy for locally advanced thymic tumors with cisplatin, etoposide, and radiation is well tolerated, with many patients having a partial radiographic response. " 06/01/2010 - "The combined etoposide, ifosfamide, and cisplatin regimen has moderate activity in patients with advanced thymic tumors. "
5.	Etoposide (VP 16)FDA LinkGeneric 02/01/2008 - "Induction therapy for locally advanced thymic tumors with cisplatin, etoposide, and radiation is well tolerated, with many patients having a partial radiographic response. " 11/01/2005 - "[Thymic cancer effectively treated by combination chemotherapy of carboplatin and etoposide with concurrent radiotherapy]." 06/01/2010 - "The combined etoposide, ifosfamide, and cisplatin regimen has moderate activity in patients with advanced thymic tumors. " 06/01/2001 - "Patients with thymic tumors (thymoma and thymic carcinoma) are known to respond to a variety of chemotherapeutic agents, including single-agent ifosfamide and cisplatin with etoposide. " 10/01/1995 - "A study was conducted to evaluate the impact of cisplatin, doxorubicin, cyclophosphamide and etoposide (PACE) with granulocyte colony-stimulating factor (G-CSF) on advanced thymoma or thymic cancer. "
6.	Doxorubicin (Adriamycin)FDA LinkGeneric 10/20/2000 - " patients received sequential chemotherapy for 3-6 cycles (cisplatin-based regimens for lung cancer and thymic tumor,cyclophosphamide and adriamycin and fluoracil for breast cancer).Kaplan-Meier curve was used to evaluate the pleural effusion control rate and survival rate of patients. " 05/01/1998 - "Although no definitive chemotherapy regimen for thymic cancer has yet been established, we feel that the cisplatin, doxorubicin, cyclophosphamide, vincristine 4-drug combination regimen is effective in thymic cancer patients. " 10/01/1995 - "A study was conducted to evaluate the impact of cisplatin, doxorubicin, cyclophosphamide and etoposide (PACE) with granulocyte colony-stimulating factor (G-CSF) on advanced thymoma or thymic cancer. " 10/01/1995 - "Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer: preliminary results." 10/01/1995 - "Between August 1989 and December 1994, 14 patients with invasive, metastatic or recurrent thymoma or thymic cancer were treated with cisplatin (80 mg/m2, on day 1), doxorubicin (45 mg/m2, on day 1), cyclophosphamide (800 mg/m2, on day 1) and etoposide (80 mg/m2, on day 1-3) with G-CSF (90 micrograms/m2, on day 5-18) at the National Cancer Center Hospital, Tokyo. "
7.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/20/2000 - " patients received sequential chemotherapy for 3-6 cycles (cisplatin-based regimens for lung cancer and thymic tumor,cyclophosphamide and adriamycin and fluoracil for breast cancer).Kaplan-Meier curve was used to evaluate the pleural effusion control rate and survival rate of patients. " 05/01/1998 - "Although no definitive chemotherapy regimen for thymic cancer has yet been established, we feel that the cisplatin, doxorubicin, cyclophosphamide, vincristine 4-drug combination regimen is effective in thymic cancer patients. " 10/01/1995 - "A study was conducted to evaluate the impact of cisplatin, doxorubicin, cyclophosphamide and etoposide (PACE) with granulocyte colony-stimulating factor (G-CSF) on advanced thymoma or thymic cancer. " 10/01/1995 - "Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer: preliminary results." 10/01/1995 - "Between August 1989 and December 1994, 14 patients with invasive, metastatic or recurrent thymoma or thymic cancer were treated with cisplatin (80 mg/m2, on day 1), doxorubicin (45 mg/m2, on day 1), cyclophosphamide (800 mg/m2, on day 1) and etoposide (80 mg/m2, on day 1-3) with G-CSF (90 micrograms/m2, on day 5-18) at the National Cancer Center Hospital, Tokyo. "
8.	sunitinib (Sutent)FDA Link 04/01/2015 - "Sunitinib effective for rare thymus cancer." 04/01/2015 - "In a phase II trial, the tyrosine kinase inhibitor sunitinib was effective in previously treated patients with thymic carcinoma, offering the first viable second-line treatment option for patients with this rare and aggressive form of thymus cancer. " 10/01/2010 - "We will briefly review the molecular genetics of malignant thymic tumors, summarize the current status of targeted therapies with an emphasis on the multitargeted kinase inhibitors sunitinib and sorafenib, and try to outline some future directions."
9.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 04/01/2015 - "In a phase II trial, the tyrosine kinase inhibitor sunitinib was effective in previously treated patients with thymic carcinoma, offering the first viable second-line treatment option for patients with this rare and aggressive form of thymus cancer. "
10.	Paclitaxel (Taxol)FDA LinkGeneric 06/01/2002 - "This case demonstrates that induction chemoradiotherapy with CDDP and paclitaxel may be well tolerated and useful for patients with advanced thymic cancer." 12/01/2014 - "[A case of thymic cancer effectively treated by weekly paclitaxel combined with carboplatin]." 12/01/2014 - "Weekly paclitaxel combined with carboplatin appears to be a useful regimen with minimal toxicity for advanced thymic cancer." 11/01/2010 - "Carboplatin plus paclitaxel can be an active agent against pretreated thymic cancer." 11/01/2010 - "[A case of recurrent invasive thymic cancer showing a stable disease to carboplatin plus paclitaxel]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 05/01/2014 - "To date research efforts are focused on translational studies on molecular pathways involved in thymic tumors carcinogenesis, aimed to better understand and predict the efficacy of chemotherapy and targeted therapy. " 12/01/1999 - "ADOC chemotherapy appears to be an effective treatment for thymic cancer." 02/01/2015 - "In this largest trial with TC, CbP showed promising efficacy in advanced TC when compared with anthracycline-based chemotherapy, which is the current standard treatment of thymic neoplasm. " 05/01/2014 - "Thymic neoplasms: an update on the use of chemotherapy and new targeted therapies. " 04/01/2013 - "In this review, we discuss the evaluation of the patient with an anterior mediastinal mass, the classification and staging of thymic neoplasms, the role of surgery, radiation and chemotherapy in treating this disease, as well as future directions in research for novel targeted therapies."
2.	Thymectomy 04/01/2002 - "The aim of this study is to evaluate the impact of thymectomy in patients with thymic neoplasms and to identify clinical and histopathological factors associated with improved long-term outcome of surgery. " 02/01/2015 - "VATS thymectomy for early-stage thymic tumors is safe and feasible. " 02/01/2015 - "Between April 2010 and April 2012, the data of 245 patients who underwent thymectomy for thymic tumors were prospectively collected. " 07/01/2014 - "Patients who underwent thymectomy (n = 262) for a thymic tumor (1986-2010) were identified from a prospective database. " 05/01/2014 - "Robotic thymectomy for thymic neoplasms."
3.	Radiotherapy 02/01/2011 - "The role of radiotherapy in the management of thymic tumors." 10/01/2010 - "Radiotherapy for thymic neoplasms." 09/01/2009 - "The role of postoperative radiotherapy in the management of patients with thymic tumors -- a retrospective study." 06/01/2008 - "The role of radiotherapy for patients who have thymic neoplasms remains unclear. " 01/01/1969 - "[Radiologic exploration and radiotherapy of thymic tumors]."
4.	Combination Drug Therapy (Combination Chemotherapy) 01/01/2005 - "Thymic tumors are chemoresponsive with optimal responses achieved with cisplatin-based combination chemotherapy. " 08/01/2011 - "Combination chemotherapy with carboplatin and paclitaxel for advanced thymic cancer." 11/01/2005 - "[Thymic cancer effectively treated by combination chemotherapy of carboplatin and etoposide with concurrent radiotherapy]."
5.	Intra-Arterial Infusions 11/01/2003 - "These results show that intra-arterial infusion chemotherapy may be effective for local control of advanced thymic cancer." 11/01/2003 - "[A case of advanced thymic cancer successfully treated with neoadjuvant intra-arterial infusion chemotherapy]."