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Moxisylyte (Thymoxamine)

An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)

Also Known As:

Thymoxamine; Acetoxythymoxamine; Arkopharma Brand of Moxisylyte Hydrochloride; Carlytène; Hansam Brand of Moxisylyte Hydrochloride; Icavex; Moxisylyte Hydrochloride; Opilon Brand of Moxisylyte Hydrochloride; Viatris Brand of Moxisylyte Hydrochloride; Hydrochloride, Moxisylyte; Thymoxyalcylamine; Phenol, 4-(2-(dimethylamino)ethoxy)-2-methyl-5-(1-methylethyl)-, acetate (ester)

Networked: 74 relevant articles (5 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Methylamines: 8
    - Dimethylamines
      - Moxisylyte: 74
        deacetylmoxisylyte
        demethyldeacetylmoxisylyte
        NMI 221

Experts

1.	Laffont, I: 1 article (02/2001)
2.	Dizien, O: 1 article (02/2001)
3.	Boyer, F: 1 article (02/2001)
4.	Lebib Ben Achour, S: 1 article (02/2001)
5.	Boiteau, F: 1 article (02/2001)
6.	Takahashi, H: 1 article (03/2000)
7.	Yamanishi, T: 1 article (03/2000)
8.	Sekita, N: 1 article (03/2000)
9.	Hattori, T: 1 article (03/2000)
10.	Suenaga, T: 1 article (03/2000)

Related Diseases

1.	Diabetes Mellitus 01/01/1992 - "Effect of moxisylyte hydrochloride (alpha 1-blocker) on the retinal circulation of patients with diabetes mellitus." 11/01/1991 - "[Acute and chronic effect of moxisylyte hydrochloride on the retinal circulation in diabetes mellitus]." 01/01/1992 - "Since retinal circulation in patients with diabetes mellitus was improved by moxisylyte, the drug may be useful to treat ocular disorders such as diabetic retinopathy." 11/01/1991 - "These results suggested that oral moxisylyte improved the retinal circulation and might support the concept that moxisylyte hydrochloride has clinical usefulness in patients with diabetes mellitus."
2.	Cataract (Cataracts) 02/01/1997 - "[Reduction of endothelial cell number by cataract operation with intraocular thymoxamine administration. " 01/01/1986 - "Intracameral thymoxamine is a potent miotic during operations and can be helpful in extracapsular cataract surgery, keratoplasty, and repair of perforating injuries." 11/01/1994 - "In a placebo-controlled prospective study, thymoxamine 0.02% or acetylcholine 1.0% or thymoxamine 0.01% plus acetylcholine 0.5% were used intraocularly to reverse mydriasis during cataract surgery. " 11/01/1995 - "We presume this mineralization to be dystrophic, with calcium derived from lens remnants and phosphorus possibly derived from a thymoxamine solution used briefly during the cataract operation. "
3.	Eye Diseases (Eye Disease) 11/01/1979 - "Thymoxamine may be of use as a diagnostic test for thyroid eye disease, and if it can be modified to cause less ocular irritation, it may be beneficial in the medical treatment of eyelid retraction." 01/01/1993 - "The effects of thymoxamine 0.5% solution and of a placebo solution (mannitol) on the mydriasis induced by ibopamine 1% solution were evaluated in 8 healthy volunteers and 12 patients with eye diseases. "
4.	Wounds and Injuries (Trauma) 01/01/1986 - "Intracameral thymoxamine is a potent miotic during operations and can be helpful in extracapsular cataract surgery, keratoplasty, and repair of perforating injuries."
5.	Myopia 06/01/1990 - "Topical cyclopentolate or atropine, or systemic hexamethonium eliminated much of the myopia, while epinephrine, phenylephrine and thymoxamine had little effect. "

Related Drugs and Biologics

1.	Moxisylyte (Thymoxamine)
2.	Retinaldehyde (Retinal)
3.	Phenylephrine (Neo-Synephrine)
4.	Epinephrine (Adrenaline)
5.	Hexamethonium (Hexamethonium Bromide)
6.	Cyclopentolate (Cyclogyl)
7.	Atropine (Hyoscyamine)
8.	Tropicamide
9.	Adrenergic Receptors (Adrenergic Receptor)
10.	Propranolol (Inderal)

Related Therapies and Procedures

1.	Corneal Transplantation (Keratoplasty)
2.	Injections
3.	Penetrating Keratoplasty
4.	Trabeculectomy (Trabeculoplasty)
5.	Intraocular Lenses (Intraocular Lens)