Thymidylate Synthase

An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.

Also Known As:

Networked: 1972 relevant articles (74 outcomes, 282 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fukushima, Masakazu: 32 articles (12/2019 - 01/2002)
2.	Peters, G J: 18 articles (11/2017 - 03/2000)
3.	Marverti, Gaetano: 17 articles (04/2021 - 08/2009)
4.	Danenberg, Peter V: 16 articles (10/2016 - 03/2002)
5.	Lenz, Heinz-Josef: 15 articles (01/2019 - 01/2002)
6.	Peters, Godefridus J: 15 articles (01/2019 - 01/2002)
7.	Costi, Maria Paola: 13 articles (04/2021 - 08/2009)
8.	Ponterini, Glauco: 13 articles (04/2021 - 08/2011)
9.	Danenberg, Kathleen D: 13 articles (01/2014 - 03/2002)
10.	Wada, Hiromi: 12 articles (12/2019 - 02/2002)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2000 - "We assessed the importance of Thymidylate Synthase (TS) expression as a prognostic factor and as an index of therapeutic efficacy in patients with colorectal carcinoma. " 11/01/2021 - "The aim of the current study was to investigate the prognostic and predictive significance of polymorphisms in the thymidylate synthase (TS) gene, alongside the loss of heterozygocity (LOH) at this gene locus in patients with colorectal cancer. " 01/01/2021 - "The purpose of this study was to study the role of thymidylate synthetase (TYMS) and B-cell lymphoma-2 like 1 (BCL2L1) in the occurrence and development of colorectal cancer and its potential regulatory mechanism. " 09/01/2014 - "The effects of thymidylate synthase (TS) polymorphisms on susceptibility to colorectal cancer (CRC) have been investigated in many studies, but the results remain conflicting rather than conclusive. " 10/08/2012 - "Although many studies have investigated the prognostic effect of thymidylate synthase (TS) in colorectal cancer, no consensus has been reached. "
2.	Neoplasms (Cancer) 03/01/2016 - "The efficacy of S-1 is better in thymidylate synthase-negative, OPRT-positive, and DPD-negative tumors. " 08/01/2001 - "Chemotherapeutic agents targeting thymidylate synthase (TS) are effective against human tumors. " 05/27/2000 - "In advanced colorecal cancer, clinical results have confirmed the therapeutic efficacy of direct and indirect thymidylate synthetase inhibitors. " 10/10/2022 - "Clinical studies of cancer patients have shown that overexpression or amplification of thymidylate synthase (TS) correlates with a worse clinical outcome. " 01/15/2021 - "Previous studies have demonstrated thymidylate synthase as a successful anti-cancer therapeutic drug target, leading to various anti-cancer drugs. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/01/2017 - "To date, many studies have suggested that thymidylate synthase (TS) could be used as a prognostic and predictive marker in non-small cell lung cancer (NSCLC) patients. " 01/01/2021 - "Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer." 01/01/2019 - "Predictive and Prognostic Value of 18F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer." 12/01/2018 - "We aimed to identify predictive clinicoradiologic characteristics of thymidylate synthase (TS) expression status in advanced non-squamous non-small cell lung cancer patients. " 12/01/2017 - "Predictive Significance of Thymidylate Synthase Expression in Non-small Cell Lung Cancer."
4.	Stomach Neoplasms (Stomach Cancer) 12/01/2016 - "Several studies have identified the role of thymidylate synthase (TS) 5'- and 3'-UTR and gastric cancer susceptibility; however, the results still remain inconclusive. " 02/01/2014 - "In our study, we investigate the possible association of thymidylate synthase polymorphism, 28 bp tandem repeat in 5'-UTR (transcription enhancer element) with susceptibility of colorectal and gastric cancer in Tunisian population. " 01/01/2012 - "Our meta-analysis suggests that the 3R variant of Thymidylate synthase 5'-untranslated enhanced region 2R/3R polymorphism contributes to gastric cancer risk in the Caucasian population, while any association in Asian populations needs further study." 01/01/2012 - "Studies investigating the association between 2R/3R polymorphisms in the thymidylate synthase 5'-untranslated enhanced region (TYMS 5'-UTR) and gastric cancer risk have generated conflicting results. " 12/01/2016 - "Association between polymorphisms of thymidylate synthase gene 5'- and 3'-UTR and gastric cancer risk: meta-analysis."
5.	Neoplasm Metastasis (Metastasis) 10/31/2022 - "The inhibition of metastasis correlated with a decrease in thymidylate synthetase (TYMS), which has recently been associated with metastatic phenotype development. " 01/01/2019 - "The M10 group had a higher proportion of patients with stage M1a (intrathoracic metastasis alone) and exhibited lower levels of thymidylate synthase (TS) than the F10 group (median H-score 10.0% vs. 60.0%; P = 0.031). " 04/01/2016 - "To decide upon additional treatment options, molecular analysis was performed on liver metastasis which revealed KRAS, FBXW7, APC, and ATM mutations, with thymidylate synthase (TS) negativity and PD-1 positivity. " 03/01/2014 - "The prognostic value of p53, Ki-67 and thymidylate synthase in patients undergoing radical resection of colorectal liver metastases." 04/01/2007 - "Thymidylate synthase expression in primary colorectal tumours is correlated with its expression in metastases."

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
3.	Thymidine Phosphorylase
4.	Enzymes
5.	Pemetrexed (MTA)
6.	raltitrexed (D 1694)
7.	Oxaliplatin (Eloxatin)
8.	Leucovorin (Folinic Acid)
9.	Messenger RNA (mRNA)
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Adjuvant Chemotherapy
3.	Therapeutics
4.	Chemoradiotherapy
5.	Radiotherapy