Thymidine

04/01/1985 - "These results show that concentrated thymidine solutions are highly effective against human tumor heterotransplants in nude mice and suggest that clinical use of concentrated thymidine may allow practical administration of maximum tolerated doses of this drug."
01/01/2011 - "The methyl-[3H]-thymidine incorporation assay is a widely used, gold standard, method for measuring inhibition of cell proliferation and has been used successfully to screen and optimize potential new cancer drugs. "
08/01/1970 - "Cells from the peritoneal exudate of immunized guinea pigs inhibited tritiated thymidine uptake by tumor target cells to a significantly greater degree than cells from the peritoneal exudate of unimmunized animals. "
08/01/2008 - "Preliminary in vivo studies demonstrated the efficacy of these [(18)F]- N(3)-substituted thymidine analogues for PET imaging of tumors."
09/01/1997 - "Other approaches with the suppressor gene p53 and herpes simplex virus thymidine synthase gene as a suicide gene system have shown substantial tumor remission and clinical trials are currently underway. "

09/01/1980 - "The incorporation of tritiated thymidine was significantly greater for lymphocytes from mice infected with the pathogenic Indonesian strain than for lymphocytes from mice infected with the non-pathogenic Formosan strain in response to SAA; the responses also increased with duration of infection. "
10/30/2001 - "The present study investigated the effect of 3'-azido 3'deoxythymidine (AZT) treatment on in vitro infection of human cord blood mononuclear cells (CBMCs) exposed to HTLV-1 by cocultivation with the MT-2 cell line. "
01/01/2008 - "Cells in these classes can be identified by immunophenotyping, labeling with thymidine analogues, and infection with retro- and lentiviral vectors. "
02/01/2004 - "Different viral rebound following discontinuation of antiretroviral therapy in cases of infection with viruses carrying L74V or thymidine-associated mutations."
02/01/2004 - "The proliferation of CD4+ T helper cells, which was evaluated by thymidine incorporation, was not different between the 2 infections. "

12/08/2006 - "3'-Azido 3'-deoxythymidine (AZT) is a thymidine analog that has been proven useful in the treatment of acquired immunodefiency syndrome (AIDS). "
06/01/1998 - "AZT is a thymidine analogue useful in the treatment of AIDS. "
04/01/2002 - "Quantitative MR spectroscopic imaging of brain lesions in patients with AIDS: correlation with [11C-methyl]thymidine PET and thallium-201 SPECT."
06/01/1992 - "In AIDS patients, less pronounced impairment of thymidine uptake by the naive subset was found upon PHA and cross-linked anti-CD3 MoAb stimulation. "
04/01/1989 - "3'-Azido-2'3'-dideoxythymidine (AZT), a thymidine analogue with potent antiretroviral activity against human immunodeficiency virus (HIV) in vitro, has been shown to confer a clinical benefit in patients with advanced acquired immune deficiency syndrome (AIDS). "

01/01/2014 - "In the present study the antiproliferative effect of these mAbs was investigated on HER2-overexpressing human breast cancer cell line BT474, using radioactive thymidine incorporation assay. "
01/01/2007 - "The aim of the present study was to determine the prognostic relevance of thymidine labeling index (TLI) in patients with breast cancer. "
08/01/2004 - "The aim of this study is to evaluate the prognostic role of thymidine labeling index in patients with breast cancer. "
06/01/2002 - "Human breast cancer cell lines (ZR-75-1, SK-BR-3, MCF-7) and a benign cell line (HBL-100) were used to study the hourly thymidine uptake as a measure of cells in synthesis. "
02/15/2001 - "Competition studies with HPX and thymidine transport via ENT2 indicated an overlap between nucleoside and nucleobase transport transporters in the breast cancer cell lines (MCF7 and T-47D). "

12/01/1994 - "In the present study, the effects of VIP on the growth of two human pancreatic carcinoma cell lines PU-PAN-1 and PANC-1 were determined using tritiated thymidine incorporation. "
01/01/1986 - "A thymidine labeling study of cell kinetics of 61 in situ breast carcinomas showed relationships between histological characteristics and kinetics. "
02/01/1976 - "Studies using [3H]thymidine autoradiography on the cell proliferation kinetics in the process of carcinoma development showed that a labeling index became higher as the malignant changes of the epithelium advanced. "
01/01/1966 - "[H3 index and mean generation time of human uterine cervical carcinoma and its preliminary stages (autoradiographic studies with H3-thymidine)]."
05/01/2011 - "Positron emission tomography (PET)/computed tomography (CT) imaging of suspected new and recurrent ovarian carcinoma was performed to assess the relationship between [(18)F] 3'deoxy-3'fluorothymidine ((18)FLT) uptake and histopathological tissue markers of cellular proliferation (Ki67) and thymidine kinase-1 (TK-1) expression. "