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Thromboplastin (Tissue Factor)

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Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.

Also Known As:

Tissue Factor; Blood Coagulation Factor III; Coagulin; Glomerular Procoagulant Activity; Prothrombinase; Tissue Factor Procoagulant; Urothromboplastin; Activity, Glomerular Procoagulant; Factor III, Coagulation; Procoagulant Activity, Glomerular; Procoagulant, Tissue Factor; Thromboplastin, Tissue; Antigens, CD142; CD142 Antigens; Coagulation Factor III; Factor III; Tissue Thromboplastin; Blood-coagulation factor III

Networked: 3348 relevant articles (41 outcomes, 294 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mackman, Nigel: 83 articles (11/2015 - 07/2002)
2.	Ruf, Wolfram: 45 articles (12/2015 - 01/2003)
3.	Rak, Janusz: 23 articles (01/2015 - 02/2004)
4.	Levi, Marcel: 21 articles (07/2012 - 02/2002)
5.	Lüscher, Thomas F: 20 articles (01/2015 - 04/2002)
6.	Versteeg, Henri H: 19 articles (10/2015 - 07/2002)
7.	Tanner, Felix C: 19 articles (09/2014 - 04/2005)
8.	Mackman, N: 18 articles (08/2015 - 03/2000)
9.	Pawlinski, Rafal: 18 articles (11/2014 - 05/2003)
10.	Kisiel, Walter: 17 articles (04/2015 - 01/2002)

Related Diseases

1.	Disseminated Intravascular Coagulation 01/01/2014 - "Although tissue factor-mediated and NET-mediated immunothrombosis plays a role in early host defense against bacterial dissemination, uncontrolled immunothrombosis may lead to disseminated intravascular coagulation. " 06/01/2011 - "Tissue factor as a target for the treatment of disseminated intravascular coagulation." 04/01/2008 - "Additionally, one should exercise caution if there is evidence of activated coagulation, such as that seen with excessive tissue factor release or disseminated intravascular coagulation. " 01/01/2002 - "Because pathophysiology differed remarkably between the tissue factor- and lipopolysaccharide-induced disseminated intravascular coagulation models in rats, we recommend that they be assessed carefully as distinct entities to determine implications of their experimental and clinical use." 01/01/2002 - "Tissue factor and lipopolysaccharide frequently have been used to induce disseminated intravascular coagulation in experimental animal models. "
2.	Thrombosis (Thrombus) 01/01/2014 - "Recent studies have shown that statins reduce thrombosis via multiple pathways, including inhibiting platelet activation and reducing the pathologic expression of the procoagulant protein tissue factor. " 01/01/2010 - "The aim of the current study was to investigate whether differences exist among strains in models of hemostasis and thrombosis and whether these differences are reflected in differences in the tissue factor (TF) pathway. " 03/01/1996 - "The aim of this study was to compare recombinant thromboplastin (rTF, ISI = 0.82) with rabbit thromboplastin (RT, ISI = 1.46) in order to evaluate which performed better in our thrombosis centre. " 01/01/1987 - "(1) Study on the role of tissue thromboplastin in the formation of thrombosis]." 11/01/2015 - "Tissue factor (TF) plays a pivotal role in the pathophysiology of cardiovascular thrombosis by triggering the formation of intracoronary thrombi following endothelial injury. "
3.	Neoplasms (Cancer) 11/15/2009 - "In cancer patients without VTE, a retrospective analysis revealed a 1-year cumulative incidence of VTE of 34.8% in patients with tissue factor-bearing microparticles versus 0% in those without detectable tissue factor-bearing microparticles (Gray test P = 0.002).The median number of tissue factor-bearing microparticles in the cancer VTE cohort (7.1 x 10(4) microparticles/microL) was significantly greater than both the idiopathic VTE and cancer-no VTE groups (P = 0.002 and P = 0.03, respectively). " 10/01/2015 - "Especially the initiator of coagulation, tissue factor (TF), has been subject to many studies investigating the overlap between coagulation and cancer. " 06/07/2012 - "In the present study, we analyzed tissue factor (TF) expression in 4 different human pancreatic tumor cell lines for the purpose of producing derivative tumors in vivo. " 02/01/2011 - "This study determines the impact of tissue factor (TF)-signaling on the extrinsic pathway of apoptosis in cancer cells and propose death associated protein kinase-1 (DAPK1) as a novel key regulator. " 06/01/2010 - "In this study, we analyzed levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE. "
4.	Hemorrhage 04/01/2010 - "In preliminary studies on low tissue factor mice, there also appears to be a delay in wound healing with evidence of bleeding into the granulation tissue. " 01/01/2009 - "This study was undertaken to evaluate prospectively how tissue factor (TF) activated TEG correlated to clinical signs of bleeding in dogs, compared to a routine coagulation profile. " 04/01/2008 - "A patient with spontaneous hemorrhage from multiple body sites was found to have markedly prolonged international normalized ratio (INR) and activated partial thromboplastin times (aPTT) with incomplete correction of aPTT on mixing studies using normal plasma. " 01/01/2005 - "This study investigates the predictive value of commonly used coagulation tests (thromboplastin time, partial thromboplastin time and thrombocyte count) compared with a standardized bleeding history. " 07/01/1981 - "The Australasian Reference Thromboplastin: I. A study in bleeding patients."
5.	Inflammation 08/01/2005 - "These findings suggest that modifying host responses would be an effective therapeutic strategy, and treatment of infected macaques with a tissue-factor inhibitor reduced both inflammation and viral replication and improved survival." 07/01/2006 - "In this preliminary study in patients with AS, tissue factor levels were high and correlated with laboratory tests for inflammation. " 02/01/2006 - "Interventions aiming at limiting tissue factor activities have been evaluated in multiple experimental studies and the observed results have supported the potential benefits for coagulation disorders, inflammation, and survival. " 10/01/2015 - "Tissue Factor Expressed by Neutrophils: Another Piece in the Vascular Inflammation Puzzle." 04/24/2015 - "It has long been known that Tissue Factor (TF) plays a role in blood coagulation and has a direct thrombotic action that is closely related to cardiovascular risk, but it is becoming increasingly clear that it has a much wider range of biological functions that range from inflammation to immunity. "

Related Drugs and Biologics

1.	Factor Xa (Coagulation Factor Xa)
2.	Heparin (Liquaemin)
3.	Thrombin
4.	Prothrombin (Factor II)
5.	Anticoagulants
6.	Fibrinogen (Factor I)
7.	Dacarbazine (DIC)
8.	Plasminogen Activators (Plasminogen Activator)
9.	Thrombomodulin
10.	Antithrombin III

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Lasers (Laser)
3.	Immunomodulation
4.	Drug Therapy (Chemotherapy)
5.	Transplants (Transplant)