Thoracic Outlet Syndrome (Syndrome, Thoracic Outlet)

A neurovascular syndrome associated with compression of the BRACHIAL PLEXUS; SUBCLAVIAN ARTERY; and SUBCLAVIAN VEIN at the superior thoracic outlet. This may result from a variety of anomalies such as a CERVICAL RIB, anomalous fascial bands, and abnormalities of the origin or insertion of the anterior or medial scalene muscles. Clinical features may include pain in the shoulder and neck region which radiates into the arm, PARESIS or PARALYSIS of brachial plexus innervated muscles, PARESTHESIA, loss of sensation, reduction of arterial pulses in the affected extremity, ISCHEMIA, and EDEMA. (Adams et al., Principles of Neurology, 6th ed, pp214-5).
Also Known As:
Syndrome, Thoracic Outlet; Aperture Syndrome, Thoracic Outlet; Arterial Thoracic Outlet Syndrome; Nerve Compression Syndrome, Thoracic Outlet; Neurogenic Thoracic Outlet Syndrome; Neurologic Syndrome, Thoracic Outlet; Superior Thoracic Aperture Syndrome; Thoracic Outlet Neurologic Syndrome; Thoracic Outlet Neurovascular Syndrome; Thoracic Outlet Syndrome, Neurogenic; Venous Thoracic Outlet Syndrome; Costoclavicular Syndromes; Outlet Syndrome, Thoracic; Outlet Syndromes, Thoracic; Syndrome, Costoclavicular; Syndrome, Scalenus Anticus; Syndromes, Costoclavicular; Syndromes, Thoracic Outlet; Thoracic Outlet Syndromes; Costoclavicular Syndrome; Neurovascular Syndrome, Thoracic Outlet; Scalenus Anticus Syndrome; Thoracic Outlet Nerve Compression Syndrome
Networked: 139 relevant articles (8 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Thrombosis (Thrombus)
2. Cicatrix (Scar)
3. Pain (Aches)
4. Radiculopathy (Radiculopathy, Cervical)
5. Paralysis (Palsy)


1. Ozçakar, Levent: 5 articles (07/2010 - 04/2005)
2. Freischlag, Julie A: 3 articles (05/2012 - 03/2010)
3. Christo, Paul J: 3 articles (05/2012 - 03/2010)
4. Sanders, Richard J: 2 articles (03/2015 - 12/2007)
5. Wittenberg, Anna M: 2 articles (05/2013 - 01/2013)
6. Rastogi, Rahul: 2 articles (05/2013 - 01/2013)
7. Thompson, Robert W: 2 articles (05/2013 - 01/2013)
8. Emery, Valerie B: 2 articles (05/2013 - 01/2013)
9. Earley, Jeanne A: 2 articles (05/2013 - 01/2013)
10. Caputo, Francis J: 2 articles (05/2013 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thoracic Outlet Syndrome:
1. Botulinum Toxins (Botulinum Toxin)IBA
2. Type A Botulinum Toxins (Botulinum A Toxin)FDA Link
3. tebufenozide (Mimic)IBA
4. SeprafilmIBA
5. Aberrant subclavian arteryIBA
6. glucuronyl glucosamine glycan sulfate (Vessel)IBA
7. Carbon MonoxideIBA
8. tranilast (N 5')IBA
9. Urokinase-Type Plasminogen Activator (Urokinase)FDA Link
10. TitaniumIBA

Therapies and Procedures

1. Decompression
2. Surgical Decompression
3. Injections
4. Aftercare (After-Treatment)
5. Thrombolytic Therapy