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Thiram

A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.

Also Known As:

Bacteriostat; Nobecutan; Novartis Brand of Thiram; Sadoplon 75; TMT Disulfide; TMTD; Tetramethylthiuram Disulfide; Thiuram; Thiuram D; Disulfide, TMT; Disulfide, Tetramethylthiuram; Thiram Novartis Brand; Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetramethyl-

Networked: 139 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Schnuch, Axel: 4 articles (11/2015 - 05/2002)
2.	Huff, G R: 4 articles (11/2007 - 07/2005)
3.	Huff, W E: 4 articles (11/2007 - 07/2005)
4.	Rath, N C: 4 articles (11/2007 - 07/2005)
5.	Bauer, Andrea: 3 articles (11/2015 - 05/2002)
6.	Uter, Wolfgang: 3 articles (11/2015 - 08/2010)
7.	Hasdai, A: 3 articles (07/2012 - 08/2007)
8.	Kieć-Świerczyńska, Marta: 2 articles (11/2015 - 03/2015)
9.	Wilkinson, Mark: 2 articles (11/2015 - 03/2015)
10.	Kręcisz, Beata: 2 articles (11/2015 - 03/2015)

Related Diseases

1.	Hypersensitivity (Allergy) 10/01/2009 - "Finally, the prevalence of thiuram allergy is decreasing as a result of improved rubber glove production." 08/01/2013 - "Further studies are needed to clarify the reason for the over-representation of thiuram allergy in patients sensitized to IPBC." 10/01/1973 - "[Experimental study of the effect of route of administration of tetramethylthiuram disulfide on the development of allergic reactions]." 11/01/2015 - "Contact allergy to thiuram mix declined over the studied time period, with an overall prevalence of 1.87%. " 08/01/2013 - "A significant relationship between IPBC and thiuram mix allergy was found. "
2.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia) 12/01/2007 - "1. An experiment was conducted to study the effect of thiram on liver antioxidant capacity and incidence of tibial dyschondroplasia in broilers. " 02/01/2013 - "Thiram is a dithiocarbamate pesticide that causes tibial dyschondroplasia (TD), a growth plate defect, in poultry. " 04/01/2009 - "Identification of differentially expressed genes in the growth plate of broiler chickens with thiram-induced tibial dyschondroplasia." 12/01/2007 - "Effect of diet with thiram on liver antioxidant capacity and tibial dyschondroplasia in broilers." 11/01/2007 - "Thiram-induced changes in the expression of genes relating to vascularization and tibial dyschondroplasia."
3.	Allergic Contact Dermatitis 11/01/2015 - "Persistent periorbital allergic contact dermatitis in a dental technician caused by airborne thiuram exposure." 02/01/2015 - "Hence, it can be supposed that they may participate in the elicitation phase of allergic contact dermatitis induced by thiram. " 05/01/2003 - "A 44-year-old woman with occupational allergic contact dermatitis to Shiitake mushroom (Lentinus edodes), sawdust and thiuram. " 08/01/2001 - "Allergic contact dermatitis due to thiuram exposure from a fungicide." 09/01/1997 - "Allergic contact dermatitis from thiuram in a veterinary medication."
4.	Alcoholism (Alcohol Abuse) 12/01/1951 - "The treatment of alcoholism with tetraethyl-thiuram disulfide in a state mental hospital; a clinical study based on 43 cases." 04/01/1952 - "[Treatment of chronic alcoholism with thiuram]." 04/01/1952 - "[Treatment of chronic alcoholism with thiuram]." 04/28/1951 - "[Tetraethyl thiuram therapy of alcoholism]." 09/15/2013 - "Here we describe the identification of disulfiram, an FDA-approved drug used to treat alcoholism, as well as the related compound thiram, as the most potent growth inhibitors following high-throughput screens of 3185 compounds against multiple TNBC cell lines. "
5.	Vitamin D Deficiency 07/01/2011 - "Thiram-induced tibial dyschondroplasia (TD) and vitamin-D deficiency rickets are avian bone disorders of different etiologies characterized by abnormal chondrocyte differentiation, enlarged and unvascularized growth plates, and lameness. " 10/01/2007 - "Two trials were conducted to determine if thiram-induced tibial dyschondroplasia (TD) in chickens was linked to a vitamin D deficiency and calcium homeostasis dysregulation, and whether feeding vitamin D fortified diets may prevent it. "

Related Drugs and Biologics

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4.	Glutaral (Glutaraldehyde)
5.	Calcium
6.	Benzalkonium Compounds (Benzalkonium Chloride)
7.	ferbam
8.	Zinc
9.	Vitamin D
10.	Venoms

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Condoms (Condom)
3.	Renal Dialysis (Hemodialysis)
4.	Oral Administration