Thiourea

A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.

Networked: 362 relevant articles (9 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Agrawal, S C: 4 articles (01/2007 - 01/2004)
2.	Gupta, S: 4 articles (01/2007 - 01/2004)
3.	Bunce, Richard A: 3 articles (01/2020 - 01/2015)
4.	Marverti, Gaetano: 3 articles (12/2019 - 04/2008)
5.	Iqbal, Jamshed: 2 articles (03/2022 - 11/2021)
6.	Soukup, Ondrej: 2 articles (02/2022 - 01/2017)
7.	Rezende, Marianne Grilo: 2 articles (01/2022 - 01/2020)
8.	Rodrigues, Carlos Rangel: 2 articles (01/2022 - 01/2020)
9.	Viana, Gil Mendes: 2 articles (01/2022 - 01/2020)
10.	de Souza, Alessandra Mendonça Teles: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/21/2016 - "Several genes that play vital roles in breast cancer pathogenesis displayed altered gene expression in the presence of a selected pyrimidinyl acyl thiourea compound. " 10/21/2016 - "Pyrimidinyl acyl thiourea derivatives may provide a drug template for effective treatment of invasive ductal breast carcinoma and its bone metastasis as well as new therapeutic perspective for drug design. " 12/01/2019 - "In an attempt to improve anti-breast cancer activity, a new series of 4-piperazinylquinoline derivatives based on the urea/thiourea scaffold were designed and synthesised by a pharmacophore hybrid approach. " 01/01/2023 - "Moreover, hybrid thiazole based thiourea scaffolds (1-21) according to literature known protocol were screened in vitro for anticancer Potential against breast cancer, antiglycation and antioxidant inhibitory profile. " 11/01/2022 - "Corrigendum to "Design, molecular docking, and molecular dynamics of thiourea-iron (III) metal complexes as NUDT5 inhibitors for breast cancer treatment" [Heliyon 8 (9) (2022) e10694]."
2.	Hyperthyroidism 02/01/1952 - "[Thiourea derivatives in hyperthyroidism; clinical and pharmacological study]." 11/25/1950 - "[Use of thiourea derivatives in hyperthyroidism]." 02/01/1948 - "The medical treatment of hyperthyroidism with derivatives of thiourea." 02/01/1948 - "Results of prolonged medical treatment of hyperthyroidism with thiourea." 01/01/1948 - "Thiourea drugs in hyperthyroidism."
3.	Hyperplasia 12/01/2022 - "Chronic exposure to thiourea induced hypertrophy and hyperplasia of follicular cells as well as a significant reduction of interstitial tissue. " 01/01/1980 - "After prolonged administration of thiourea, follicular cell masses and small follicles, which underwent conspicuous hyperplasia and hypertrophy, markedly increased in the complexes and exceeded C cells in number. " 03/01/1992 - "Nonneoplastic lesions associated with the administration of ethylene thiourea included follicular cell hyperplasia in rats and mice and follicular cell cytoplasmic vacuolation, centrilobular hepatocellular cytomegaly, and focal hyperplasia of the pars distalis of the pituitary gland in mice. " 05/01/2018 - "This study concludes that thiourea, in addition to its antithyroidal activity, develops stress in the adrenal as evident by enhanced lipid peroxidation in the gland that in turn through the HPA axis causes hypertrophy and hyperplasia of adrenocortical cells to enhance synthesis and release of corticosterone secretion to counteract the stress developed under the influence of this potent chemical agent." 03/01/1992 - "Moderately severe diffuse follicular cell hyperplasia in the thyroid gland and centrilobular cytomegaly of the liver occurred in mice receiving 2,000 ppm. Because the severity of the thyroid lesion (and degree of hypothyroidism) at this concentration was considered potentially life threatening in 2-year studies, dietary concentrations of 0, 100, 330, and 1,000 ppm ethylene thiourea were selected for adult exposure during the 2-year studies. "
4.	Edema (Dropsy) 01/01/2022 - "Following thiourea-induced lung edema, KvLQT1-KO did not worsen WLC or lung function. " 01/01/2022 - "Our aim was to further investigate the function of KvLQT1 channels and their interplay with other channels/transporters involved in ion/liquid transport in vivo using adult wild-type (WT) and KvLQT1 knock-out (KO) mice under physiological conditions and after thiourea-induced lung edema. " 08/01/1985 - "To test specificity we compared hydrostatic and high-dose thiourea edema. " 12/01/2000 - "Finally, in a thiourea toxicity model of acute endothelial injury causing pleural effusions and lung interstitial edema, pleural fluid accumulation in the first 3 h ( approximately 4 ml. kg(-1). " 06/01/1962 - "II. The effect of edema of the lungs induced by thiourea on the development of pneumonia."
5.	Hypertrophy 11/01/1985 - "Thiourea treatment induces their hypertrophy, with a decrease in tinctorial and immunohistochemical stainability. " 12/01/2022 - "Chronic exposure to thiourea induced hypertrophy and hyperplasia of follicular cells as well as a significant reduction of interstitial tissue. " 01/01/1980 - "After prolonged administration of thiourea, follicular cell masses and small follicles, which underwent conspicuous hyperplasia and hypertrophy, markedly increased in the complexes and exceeded C cells in number. " 05/01/2018 - "This study concludes that thiourea, in addition to its antithyroidal activity, develops stress in the adrenal as evident by enhanced lipid peroxidation in the gland that in turn through the HPA axis causes hypertrophy and hyperplasia of adrenocortical cells to enhance synthesis and release of corticosterone secretion to counteract the stress developed under the influence of this potent chemical agent." 01/01/1979 - "Animals treated with both thiourea and thyroxine were in hyperthyroidism: the thyroxine dose received was higher that that required to prevent thiourea-induced thyroid gland hypertrophy. "

Related Drugs and Biologics

1.	Antioxidants
2.	Thiazoles
3.	Hydroxyl Radical
4.	Iodine
5.	SPA0355
6.	graphene oxide
7.	Retinaldehyde (Retinal)
8.	Lipopolysaccharides
9.	ethylene
10.	diphenyl (biphenyl)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Therapeutics
3.	Adrenalectomy
4.	Injections
5.	Hypophysectomy