Thiosulfate Sulfurtransferase (Rhodanese)

An enzyme that catalyzes the transfer of the planetary sulfur atom of thiosulfate ion to cyanide ion to form thiocyanate ion. EC 2.8.1.1.

Also Known As:

Rhodanese; Thiosulfate Sulphurtransferase; Cyanide Transsulphurase, Thiosulfate; Sulfurtransferase, Thiosulfate; Sulphurtransferase, Thiosulfate; Transsulphurase, Thiosulfate Cyanide; Thiosulfate Cyanide Transsulphurase; Thiosulfate:cyanide sulfurtransferase

Networked: 73 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Sulfur Group Transferases
      - Sulfurtransferases: 21
        Thiosulfate Sulfurtransferase: 73
        mouse Tstd1 protein

Experts

1.	Morton, Nicholas M: 4 articles (11/2021 - 01/2016)
2.	Barrios-Llerena, Martin E: 3 articles (11/2021 - 01/2016)
3.	Carter, Roderick N: 3 articles (11/2021 - 01/2016)
4.	Gibbins, Matthew T G: 3 articles (11/2021 - 01/2016)
5.	Wróbel, Maria: 3 articles (07/2020 - 12/2014)
6.	Beltram, Jasmina: 3 articles (04/2018 - 01/2016)
7.	Horvat, Simon: 3 articles (04/2018 - 01/2016)
8.	Abraham, Annie: 3 articles (09/2014 - 09/2008)
9.	Aird, Rhona E: 2 articles (04/2018 - 01/2016)
10.	Churchill, Gary A: 2 articles (04/2018 - 01/2016)

Related Diseases

1.	Thinness 04/10/2018 - "Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness." 01/01/2016 - "Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness." 11/01/2016 - "The objective of the study was to develop an approach to integrate various genomic annotations for a recently positionally-cloned Tst gene (Thiosulfate Sulfur Transferase, synonym Rhodanese) responsible for the Fob3b2 QTL effect on leanness and improved metabolic parameters. "
2.	Infections 01/01/1955 - "[Behavior of some enzyme activities in the tissues (adenylpyrophosphatase, rhodanese) in various stages of experimental encephalomyocarditis virus infection]." 01/01/1957 - "[Biochemical study of experimental West Nile virus infections; behavior of succinodehydrogenase, asparticketoglutaric transaminase, adenylpyrophosphatase, rhodanese and hexokinase activity in the brain and liver]." 01/01/1955 - "[Biochemical study of experimental encephalomyocarditis virus infection; behavior of various enzyme activities in the brain; liver and myocardium (adenylpyrophosphatase, succinodehydrogenase, aspartico-ketoglutaric transaminase, rhodanese)]." 11/14/2019 - "In Mycobacterium tuberculosis, the causative agent of tuberculosis, the gene Rv0815c encodes the protein CysA2, a putative uncharacterized thiosulfate:cyanide sulfurtransferase that belongs to the essential sulfur assimilation pathway in the bacillus and is secreted during infection. " 10/01/2006 - "Antimony(V), which is chemically very similar to arsenic, is used instead in the treatment of leishmaniasis, an infection caused by the protozoan parasite Leishmania sp.; the reduction of pentavalent antimony contained in the drug Pentostam to the active trivalent form arises from the presence in the Leishmania genome of a gene, LmACR2, coding for the protein LmACR2 (14.5 kDa, 127 amino acids) that displays weak but significant sequence similarity to the catalytic domain of Cdc25 phosphatase and to rhodanese enzymes. "
3.	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 02/01/1989 - "Previous studies have reported an association between Leber's optic neuropathy and deficiency of rhodanese activity in liver and rectal mucosa. " 07/18/1988 - "Leber's optic atrophy and "rhodanese" activity." 05/10/1986 - "Deficiency of thiosulphate sulphurtransferase (rhodanese) in Leber's hereditary optic neuropathy." 04/01/1989 - "We studied one patient with Leber's optic atrophy (LOA) in the acute stage and 12 at the chronic stage of the disease, and measured the activity of rhodanese in white blood cells and the level of cyanide in whole blood. " 02/01/1989 - "We have studied the rhodanese isozymes in liver biopsies from three subjects with Leber's optic neuropathy. "
4.	Carcinogenesis 12/01/1954 - "Studies on rhodanese of the liver of rats during hepatic carcinogenesis." 06/01/1997 - "Rhodanese (thiosulphate:cyanide sulphurtransferase) shows distinctive mitochondrial and cytoplasmic activities in several models of tumorigenesis. " 09/01/1992 - "6. The distinctive alteration in mitochondrial and cytoplasmic rhodanese would suggest that it plays a subtle role in ALA-S regulation during carcinogenesis initiation through a mechanism that appears to involve subcellular localization controls perhaps by means of the breakage of cystine trisulphide postulated to act as an ALA-S activator. " 06/01/1995 - "Rhodanese (thiosulfate: cyanide sulfurtransferase) shows distinctive mitochondrial and cytoplasmic activities in several models of tumorigenesis. "
5.	Shock 04/15/2008 - "Previous studies indicated that the phage-shock protein E (PspE) from Escherichia coli is a rhodanese composed of a single active domain and is the only accessible rhodanese among the three single-domain rhodaneses in E. " 05/08/2002 - "PspE (phage-shock protein E) of Escherichia coli is a rhodanese."

Related Drugs and Biologics

1.	Sulfur
2.	Transferases
3.	Thiosulfates
4.	Transaminases (Aminotransferases)
5.	Enzymes
6.	Proteins (Proteins, Gene)
7.	Hexokinase
8.	Antigens
9.	Cyanides (Isocyanides)
10.	Thiosulfate Sulfurtransferase (Rhodanese)

Related Therapies and Procedures

1.	Enzyme Therapy
2.	Transplantation
3.	Therapeutics
4.	Intraperitoneal Injections
5.	Oral Administration