Thiostrepton (Gargon)

One of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.

Also Known As:

Networked: 98 relevant articles (8 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gartel, Andrei L: 13 articles (01/2014 - 06/2008)
2.	Pandit, Bulbul: 5 articles (10/2011 - 06/2010)
3.	Chen, Hongyan: 4 articles (12/2021 - 01/2014)
4.	Halasi, Marianna: 4 articles (09/2012 - 01/2009)
5.	Bhat, Uppoor G: 4 articles (01/2011 - 06/2008)
6.	Uddin, Shahab: 3 articles (12/2021 - 01/2012)
7.	Huang, Chi-Ying F: 3 articles (01/2020 - 10/2015)
8.	Jiang, Lizhu: 3 articles (06/2015 - 01/2014)
9.	Wang, Peng: 3 articles (06/2015 - 01/2014)
10.	Cunniff, Brian: 3 articles (01/2015 - 01/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Notably, pharmacological disruption of the PBX1-FOXM1 axis with existing agents (thiostrepton) and a novel PBX1 small molecule inhibitor (T417) is selectively toxic against chr1q-amp myeloma and solid tumor cells. " 12/16/2021 - "RESULTS Inhibition of FoxM1 by thiostrepton significantly suppressed NPC cell viability, induced apoptosis, increased cell cycle arrest, impaired nuclear morphology, and reduced NPC cell-derived tumor xenograft growth. " 01/01/2021 - "One M1-activating compound, thiostrepton, is able to reprogram tumor-associated macrophages toward M1-like state in mice, and exhibit potent anti-tumor activity. " 01/01/2016 - "Our results give a new insight into the mechanism of thiostrepton anti-tumor activity and suggest thiostrepton as a promising agent that targets hedgehog signaling pathway in TNBC." 11/01/2014 - "In a nude mice model, metastatic lung tumor nodules in HPV 18 E6-positive GNM or HPV 16 E6-positive TL-1-injected nude mice were markedly decreased in both cell types with E6 knockdown, FOXM1 knockdown, or treatment with FOXM1 inhibitor (thiostrepton). "
2.	Ovarian Neoplasms (Ovarian Cancer) 11/30/2014 - "Finally, FoxM1 expression is elevated in nearly all (48/49) ovarian tumors, indicating that thiostrepton target gene is highly expressed in ovarian cancer. " 01/01/2019 - "Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton." 01/01/2011 - "However, the down-regulation of FOXM1 by either thiostrepton or U0126 required the presence of p53 in ovarian cancer cells. " 10/01/2017 - "Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed. " 01/01/2017 - "Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed. "
3.	Melanoma (Melanoma, Malignant) 12/01/2008 - "Co-administration of oxidative stress-inducing drugs such as thiostrepton in order to enhance the efficacy of ATO in the treatment of melanoma warrants further investigation." 05/01/2012 - "Using comparative gene expression-array analysis, the early cellular stress response induced by thiostrepton was examined in human A375 metastatic melanoma cells and primary melanocytes. " 05/01/2012 - "Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes." 12/01/2008 - "Thiostrepton (1 microM) sensitized three out of five melanoma cell lines to ATO-mediated growth inhibition. " 12/01/2008 - "The mechanism of action for the most effective agent identified, thiostrepton, was examined in a panel of melanoma cells. "
4.	Ascites 10/01/2017 - "Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed. " 01/01/2017 - "Human ovarian cancer cell lines and patients' ascites cells were treated with paclitaxel, cisplatin, and thiostrepton or a combination for 48 hours, and cytotoxicity was assessed. " 10/01/2017 - "Targeting FOXM1 with thiostrepton decreased FOXM1 mRNA expression and its downstream targets such as CCNB1 and CDC25B, leading to cell death in both cell lines and patients' ascites cancer cells. " 01/01/2017 - "Targeting FOXM1 with thiostrepton decreased FOXM1 mRNA expression and its downstream targets such as CCNB1, CDC25B, leading to cell death in both cell lines and patients' ascites cancer cells. " 10/01/2017 - "We aimed to determine if targeting the FOXM1 pathway with thiostrepton could improve the efficacy of paclitaxel and cisplatin in human ovarian cancer ascites cells ex vivo. "
5.	Liver Neoplasms (Liver Cancer) 12/01/2011 - "In this study, we explored the potential in vivo anticancer properties of thiostrepton, delivered through nanoparticle encapsulation to xenograft models of breast and liver cancer. " 01/01/2021 - "Moreover, Artemisinin, when used in combination with Thiostrepton, an established FoxM1 inhibitor, markedly reduced anchorage-independent growth and displayed more pronounced death in liver cancer cells. " 09/15/2012 - "Here, we show the efficacy of thiostrepton-micelles in inhibiting tumor growth in a DEN/PB-induced liver cancer model. " 09/15/2012 - "We also demonstrate an enhanced anticancer effect of the combination treatment of thiostrepton with bortezomib, another proteasome inhibitor in this liver cancer model."

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Paclitaxel (Taxol)
3.	Anti-Bacterial Agents (Antibiotics)
4.	Thiazoles
5.	Oncogene Proteins (Oncogene Protein)
6.	Bortezomib (Velcade)
7.	Micelles
8.	Tocotrienols
9.	Quinine (Quinson)
10.	Quercetin

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	TP protocol
4.	Radiotherapy