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Thioridazine (Mellaril)

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A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.

Also Known As:

Mellaril; Melleril; AWD.pharma Brand of Thioridazine Hydrochloride; Aldazine; Alphapharm Brand of Thioridazine Hydrochloride; Apo-Thioridazine; Apotex Brand of Thioridazine Hydrochloride; Arzneimittelwerk Dresden Brand of Thioridazine; Clonmel Brand of Thioridazine Hydrochloride; DDSA Brand of Thioridazine Hydrochloride; Meleril; Melleretten; Melleryl; Melzine; Novartis Brand of Thioridazine; Pinewood Brand of Thioridazine Hydrochloride; Rideril; Roxane Brand of Thioridazine Hydrochloride; Sonapax; Thioridazine HCL; Thioridazine Hydrochloride; Thioridazine-neurazpharm; Thiozine; neurazpharm Brand of Thioridazine Hydrochloride; Apo Thioridazine; ApoThioridazine; Thioridazine Novartis Brand; Thioridazine neurazpharm; Thioridazineneurazpharm; 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-

Networked: 451 relevant articles (29 outcomes, 54 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Amaral, Leonard: 20 articles (03/2014 - 11/2004)
2.	Molnar, Joseph: 11 articles (03/2014 - 11/2004)
3.	Kristiansen, Jette E: 7 articles (03/2015 - 01/2005)
4.	Viveiros, Miguel: 7 articles (05/2012 - 11/2004)
5.	Karakousis, Petros C: 5 articles (12/2014 - 05/2011)
6.	van Soolingen, Dick: 5 articles (12/2014 - 01/2010)
7.	Dutta, Noton K: 5 articles (12/2014 - 05/2011)
8.	Hendricks, Oliver: 4 articles (03/2015 - 01/2005)
9.	Kolmos, Hans Jørn: 4 articles (01/2015 - 01/2005)
10.	Rho, Seung Bae: 4 articles (07/2014 - 01/2011)

Related Diseases

1.	Tuberculosis (Tuberculoses) 12/01/2014 - "Enhancement of in vitro activity of tuberculosis drugs by addition of thioridazine is not reflected by improved in vivo therapeutic efficacy." 12/01/2013 - "tuberculosis replication rates decreased, those of thioridazine improved. " 09/01/2014 - "In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. " 01/15/2015 - "The antipsychotic drug thioridazine has potential for treatment of multidrug-resistant microbes including tuberculosis but also causes cardiotoxic QT interval prolongation. " 12/01/2014 - "The articles by De Knegt et al. and Singh et al. in a recent issue of this Journal address one of the current debates regarding the potential role of thioridazine in the treatment of tuberculosis. "
2.	Schizophrenia (Dementia Praecox) 06/24/1972 - "A comparative study of the efficacy of bilateral and unilateral electroconvulsive therapy with thioridazine in acute schizophrenia." 11/01/2003 - "Thioridazine, which the UK Committee on the Safety of Medicines (CSM) recently recommended should be used only for second-line treatment of schizophrenia in adults, was the most commonly prescribed antipsychotic throughout the study period. " 08/01/1984 - "The relationship of plasma and red blood cell (RBC) levels of thioridazine to clinical response in schizophrenia was evaluated in a fixed-dose study. " 07/01/1963 - "[Clinical trials with thioridazine in schizophrenia]." 04/01/1960 - "Clinical trials with melleril (TP21) in the treatment of schizophrenia. "
3.	Extensively Drug-Resistant Tuberculosis 06/01/2010 - "Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!" 03/01/2012 - "Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine." 01/01/2012 - "Why and How the Old Neuroleptic Thioridazine Cures the XDR-TB Patient." 06/01/2010 - "Although thioridazine is beyond patent protection, its use for the therapy of XDR TB is new and therefore, a patent may be sought for "use as an anti-XDR TB agent"." 06/01/2010 - "Therapy Of XDR TB with thioridazine a drug beyond patent protection but eligible for patent "as new use"."
4.	Infection 06/01/2010 - "We have been able to demonstrate that thioridazine, a neuroleptic in safe use for over forty years, enhances the killing of phagocytosed Mycobacterium tuberculosis regardless of its antibiotic susceptibility profile and cure the mouse of a Mycobacterium tuberculosis pulmonary infection. " 02/01/2010 - "Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74." 07/01/2006 - "The authors do not suggest that thioridazine be used indiscriminately for MDRTB or intracellular infections produced by MRSA. " 10/01/1999 - "Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice." 01/01/2010 - "Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (-2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. "
5.	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 03/01/2012 - "Thioridazine: an old neuroleptic effective against totally drug resistant tuberculosis." 05/01/2011 - "The advantages are that thioridazine is inexpensive, effective against drug resistant tuberculosis, well characterized and unlikely to induce drug resistance. " 01/15/2015 - "If these results are valid in humans, (-)-thioridazine may be a safer drug for treatment of multidrug-resistant tuberculosis and other microbes. " 06/01/2013 - "Recent clinical reports suggest that thioridazine may play a role in the treatment of drug-resistant tuberculosis. " 12/01/2012 - "The added effect of thioridazine in the treatment of drug-resistant tuberculosis."

Related Drugs and Biologics

1.	Thioridazine (Mellaril)
2.	Haloperidol (Haldol)
3.	Chlorpromazine (Thorazine)
4.	phenothiazine
5.	Fluphenazine (Prolixin)
6.	Trifluoperazine (Stelazine)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Loxapine (Loxitane)
9.	Imipramine (Janimine)
10.	periciazine

Related Therapies and Procedures

1.	Home Nursing (Nursing, Home)
2.	Salvage Therapy
3.	Microelectrodes
4.	Intramuscular Injections
5.	Injections