Thioredoxins

Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE.

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Networked: 986 relevant articles (28 outcomes, 93 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yodoi, Junji: 86 articles (12/2014 - 01/2002)
2.	Nakamura, Hajime: 66 articles (05/2015 - 01/2002)
3.	Yodoi, J: 22 articles (09/2010 - 01/2000)
4.	Powis, Garth: 17 articles (08/2011 - 09/2002)
5.	Masutani, Hiroshi: 15 articles (01/2013 - 06/2002)
6.	Nakamura, H: 15 articles (05/2007 - 01/2000)
7.	Powis, G: 13 articles (06/2003 - 04/2000)
8.	Holmgren, Arne: 12 articles (12/2015 - 11/2003)
9.	Bai, Jie: 11 articles (08/2014 - 01/2002)
10.	Shioji, Keisuke: 11 articles (06/2007 - 08/2002)

Related Diseases

1.	Myocarditis (Carditis) 06/01/2004 - "Thioredoxin, a redox-regulating protein, is expressed in spontaneous myocarditis in inbred strains of mice." 06/01/2001 - "Redox regulating mechanisms may be involved in the pathogenesis of viral myocarditis and thioredoxin (TRX) is a small multifunctional protein that contains a redox active sequence. " 06/01/2001 - "Difference in thioredoxin expression in viral myocarditis in inbred strains of mice." 04/21/2000 - "Upregulation of thioredoxin (TRX) expression in giant cell myocarditis in rats." 09/07/2004 - "Exogenous thioredoxin reduces inflammation in autoimmune myocarditis."
2.	Reperfusion Injury 02/01/2014 - "Thioredoxin-interacting protein and myocardial mitochondrial function in ischemia-reperfusion injury." 01/01/2013 - "Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia/reperfusion injury: role of thioredoxin-interacting protein." 01/01/2012 - "Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury." 09/01/2010 - "Nitrative inactivation of thioredoxin-1 increases vulnerability of diabetic hearts to ischemia/reperfusion injury." 01/01/2009 - "It was reported [Fukuse T, Hirata T, Yokomise H et al. Attenuation of ischaemia reperfusion injury by human thioredoxin. "
3.	Inflammation 07/01/2009 - "Thioredoxin (TRX) is assumed to be beneficial in acute inflammatory diseases because of its potent antioxidant properties and an inhibitory effect on neutrophil evasion into sites of inflammation. " 01/01/2015 - "Changes of thioredoxin, oxidative stress markers, inflammation and muscle/renal damage following intensive endurance exercise." 11/01/2014 - "Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1α regulation in vitro and in vivo." 08/01/2014 - "Thioredoxin-1 (TRX-1) is an important redox regulator, which plays roles in resisting oxidative stress, regulating inflammation and inhibiting apoptosis. " 05/01/2014 - "Thioredoxin-interacting protein (TXNIP) has emerged as a key regulator of important cellular processes including redox state, inflammation, and apoptosis and plays a particularly critical role in pancreatic β-cell biology and diabetes development. "
4.	Fibrosis (Cirrhosis) 12/15/2015 - "Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium." 09/01/2006 - "This study aimed to clarify the protective role of thioredoxin-1 (TRX-1), a redox-regulating protein with antioxidative activity, in MCP-1 production and pancreatic fibrosis using a CP model in transgenic mice overexpressing TRX-1 (TRX-1-TG mice) and wildtype C57BL/6 mice. " 01/01/2005 - "The aim of the present study was to investigate the protective effect of thioredoxin for hepatic fibrosis. " 01/01/2005 - "Thioredoxin has a potential to attenuate hepatic fibrosis via suppressing oxidative stress and inhibiting proliferation of stellate cells." 04/20/2015 - "High serum concentrations of thioredoxin differentiated HCC from chronic liver diseases and cirrhosis (0.901 [0.875-0.923] in the training cohort; 0.906 [0.870-0.925] in the validation cohort). "
5.	Pneumonia (Pneumonitis) 01/01/2005 - "Redox regulation of lung inflammation by thioredoxin." 06/03/2002 - "Enhanced resistancy of thioredoxin-transgenic mice against influenza virus-induced pneumonia." 01/01/2013 - "Exogenous administration of recombinant human thioredoxin-1 significantly improved the survival rate and attenuated lung histological changes in the murine model of influenza pneumonia. " 05/01/2008 - "Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice."

Related Drugs and Biologics

1.	temocapril hydrochloride (temocapril)
2.	Thioredoxins
3.	Glutathione (Reduced Glutathione)
4.	Biological Markers (Surrogate Marker)
5.	adult T cell leukemia-derived factor
6.	NADPH Oxidase (NAD(P)H oxidase)
7.	Curcumin
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	NF-kappa B (NF-kB)
10.	Antioxidants

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Atherectomy
4.	Ligation
5.	Lung Transplantation