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Thioguanine (Tioguanine)

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An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Also Known As:

Tioguanine; 6 Thioguanine; 6-Thioguanine; 2-Amino-6-Purinethiol; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Lanvis; Tabloid; Thioguanin-GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Wellcome Brand of Thioguanine; 2 Amino 6 Purinethiol; Thioguanin GSK; ThioguaninGSK; Tioguanine GlaxoSmithKline Brand; 6H-Purine-6-thione, 2-amino-1,7-dihydro-

Networked: 618 relevant articles (57 outcomes, 71 trials/studies)

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Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Purines: 436
    - Thioguanine: 618

Experts

1.	de Boer, Nanne K H: 8 articles (04/2011 - 04/2005)
2.	Relling, Mary V: 6 articles (06/2015 - 06/2003)
3.	Evans, William E: 6 articles (06/2015 - 06/2003)
4.	van Bodegraven, A A: 6 articles (02/2014 - 09/2005)
5.	de Boer, N K H: 6 articles (06/2010 - 04/2005)
6.	Reinisch, Walter: 5 articles (03/2015 - 08/2005)
7.	Gilissen, L P L: 5 articles (02/2014 - 02/2007)
8.	Engels, L G J B: 5 articles (02/2014 - 02/2007)
9.	Hooymans, P M: 5 articles (02/2014 - 02/2007)
10.	Mulder, Chris J J: 5 articles (09/2010 - 01/2003)

Related Diseases

1.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2009 - "Thioguanine pharmacokinetics in induction therapy of children with acute myeloid leukemia." 11/01/2005 - "We present a case of NEH in a 70-year-old neutropenic male who received thioguanine for acute myeloid leukemia. " 08/01/2002 - "The antimetabolite 6-thioguanine (6-TG) is utilized in the management of acute myelogenous leukemia (AML). " 06/01/1985 - "Treatment of acute myelocytic leukemia with a daunorubicin-cytarabine-6 thioguanine regimen without maintenance therapy." 01/01/1985 - "All drugs used commonly in the treatment of ANLL, except 6-thioguanine, were evaluated singly and some in combination. "
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/01/2003 - "6-thioguanine: a new old drug to procure remission in inflammatory bowel disease." 02/01/2007 - "Patients attending the inflammatory bowel disease clinic who were started on 6-thioguanine therapy were included in this prospective observational study. " 02/01/2007 - "The aim of this study was to analyse our experience of the efficacy and safety of 6-thioguanine in inflammatory bowel disease. " 01/01/2004 - "To study liver biopsies from 3 patients with inflammatory bowel disease who had received thioguanine for more than a year, and who had elevated serum liver enzyme values and underwent percutaneous liver biopsy. " 08/01/2015 - "Body Mass Index and Smoking Affect Thioguanine Nucleotide Levels in Inflammatory Bowel Disease."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2002 - "6-Thioguanine has been highly effective in treating and maintaining improvement in patients with psoriasis. " 04/01/1999 - "Marked improvement of recalcitrant psoriasis was noted in 10 (71%) of 14 patients receiving thioguanine therapy using a pulse-dosing schedule. " 01/01/2001 - "Thioguanine appears to be an effective treatment for patients with severe recalcitrant psoriasis. " 12/01/1999 - "6-Thioguanine is effective for the treatment of moderate to severe plaque-type psoriasis, and may be safe when given for defined periods and with careful hematologic monitoring. " 12/01/1999 - "To test the hypothesis that the antimetabolite 6-thioguanine (Sigma-Aldrich, St Louis, Mo) might be an effective treatment for psoriasis vulgaris because of its antilymphocytic effects. "
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/01/2013 - "6-thioguanine induces mitochondrial dysfunction and oxidative DNA damage in acute lymphoblastic leukemia cells." 09/01/2000 - "6-thioguanine (6TG) is undergoing investigation for use in the maintenance phase of acute lymphoblastic leukemia (ALL). " 01/01/1999 - "Some 6-thioguanine resistant (6-TGr) clones were separated from human T cell acute lymphocytic leukemia, PEER. " 01/01/1982 - "Clinically reversible veno-occlusive disease of the liver developed in a 23-year-old man with acute lymphocytic leukemia after 10 months of maintenance therapy with 6-thioguanine. " 03/01/2001 - "Plasma pharmacokinetics and cerebrospinal fluid penetration of thioguanine in children with acute lymphoblastic leukemia: a collaborative Pediatric Oncology Branch, NCI, and Children's Cancer Group study."
5.	Crohn Disease (Crohn's Disease) 06/15/2003 - "In responders to tioguanine, the drug appears to be very effective in maintaining remission of chronic active Crohn's disease. " 02/15/2003 - ": In this patient group with chronic active Crohn's disease, 6-thioguanine appeared to be effective with acceptable short-term toxicity, but long-term controlled trials are clearly needed to further define its role." 06/15/2003 - "To evaluate the role of tioguanine in the maintenance of remission in chronic active Crohn's disease. " 06/15/2003 - "Remission maintenance by tioguanine in chronic active Crohn's disease." 10/01/2010 - "ECCO consensus: evidence-based use of 6-thioguanine therapy in Crohn's disease?"

Related Drugs and Biologics

1.	Cytarabine (Cytosar-U)
2.	Daunorubicin (Cerubidine)
3.	6-Mercaptopurine (Mercaptopurine)
4.	Nucleotides
5.	Vincristine (Oncovin)
6.	Azathioprine (Imuran)
7.	Doxorubicin (Adriamycin)
8.	Prednisone (Sone)
9.	Etoposide (VP 16)
10.	6-methylthiopurine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Remission Induction
3.	Heterologous Transplantation (Xenotransplantation)
4.	Radiotherapy
5.	Organ Transplantation