Thiocarbamates

06/01/1985 - "Synthesis and structure-activity studies on aliphatic carbamates and thiocarbamates toxic to scabies mites, Psoroptes spp. (Acari: Psoroptidae)."

01/01/2022 - "NSC 161128, a phenylurea thiocarbamate, displays activity against the NCI60 anti-cancer cell line panel and xenograft models. "
01/01/2006 - "The activity of the thiolocarbonates and thiocarbamates against human tumor xenografts in vivo suggests consideration of these two series of derivatives of DM-PEN for clinical development."
01/01/2006 - "Thiolocarbonate and thiocarbamate derivatives were found to be superior to DM-PEN against MX-1 tumor and modestly active against glioblastoma. "
04/05/2021 - "These novel carbamate or thiocarbamate derivatives of 10-demethoxy-10-methylaminocolchicine have been tested for their antiproliferative activity against four human cancer cell lines. "
03/01/2012 - "To investigate the contribution of dithiocarbamate moiety to the cytotoxic activity, three series of novel quinazolin-4(3H)-one derivatives bearing thiocarbamate, thiourea or Nmethyldithiocarbamate side chains were synthesized and tested for their cytotoxic activity against human cancer cell lines A549, MCF-7, HeLa, HT29 and HCT-116 by MTT assay. "

05/23/2023 - "Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating alcoholism for over 60 years. "
01/01/2007 - "The thiocarbamate drug disulfiram has been used for decades in the treatment of alcohol abuse. "
05/01/1998 - "Benomyl (a non-thio fungicide) inhibits hepatic mitochondrial low-Km aldehyde dehydrogenase (mALDH or ALDH2) in ip-treated mice by 50% (IC50) at 7.0 mg/kg, which is surprisingly the same potency range as that for several dithiocarbamate fungicides (and the related alcohol abuse drug disulfiram) and thiocarbamate herbicides previously known for their alcohol-sensitizing action. "
09/01/2004 - "The thiocarbamate alcoholism drug disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-kappaB, sensitizes tumors to chemotherapy, reduces angiogenesis, and inhibits tumor growth in mice. "
12/01/1995 - "Several fungicides including the dialkyldithiocarbamates as the disulfide (thiram and the related alcohol-abuse drug disulfiram) and metal salts (ziram) also yield S-methyl thiocarbamate metabolites. "

03/01/2006 - "Thiocarbamate dissociation rates and type of products formed may potentially influence antigenicity and subsequent hypersensitivity/toxic reactions following dNCO exposures."
01/01/1994 - "In general, allergy to thiocarbamates was concomitant with allergy to thiurams (20 out of 21 patients allergic to carbamates) and over-sensitivity to thiazoles was very often parallel to allergy to thiurams (8 out of 18 patients allergic to thiazoles). "
01/01/1994 - "In this group (20 workers of the metallurgical industry, 15 health service workers, 6 workers of the building and 3 of the rubber industries, 2 farmers and 5 drivers) the frequency of allergy to 15 accelerators of the thiuram group, thiocarbamates, thiazoles as well as derivatives of diphenylguanidine and thiocarbamide was investigated. "
01/01/2003 - "Following dermatological and allergological examinations, in a group of 132 farmers with suspected occupational disease, contact allergy induced by metals (chromates, nickel, cobalt, mercury), disinfectants and their components (formaldehyde, glutaraldehyde, quaternary ammonium compounds, lysol, chloramine), rubber and pesticides, especially pesticides of thiophtalimide and thiocarbamate groups were recorded. "

01/01/2012 - "To evaluate the effect of the thiocarbamate antifungal agent liranaftate on inflammation and itchiness, footpad edema by phorbol 12-myristate 13-acetate (PMA) and the paw-licking accompanying by perceptual stimuli by compound 48/80 were examined. "
01/01/2010 - "To evaluate the anti-inflammatory activity of the thiocarbamate antifungal agent liranaftate, the edema and the neutrophil accumulation detected by the activity of neutrophil marker enzyme, myeloperoxidase (MPO), were examined following application of liranaftate to mouse ears with inflammation induced by phorbol 12-myristate 13-acetate (PMA). "