Thiobarbiturates

Compounds in which one or more of the ketone groups on the pyrimidine ring of barbituric acid are replaced by thione groups.

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Barbiturates: 1074
        Thiobarbiturates: 4
        Thiopental: 1468
        thiobarbituric acid: 655
        Thiamylal: 103
        merbarone: 23
        bis(1,3-diethylthiobarbiturate)trimethineoxonol: 13
        buthalital: 4
        isothiobarbamin: 3
        bis(1,3-dihexyl-2-thiobarbiturate)trimethineoxonol: 1
        CD00509: 1
        merocil: 1
        methitural: 1
        1,3-dibutyl-2-thiobarbituric acid
        1,3-diethyl-2-thiobarbituric acid
        1,3-diphenyl-2-thiobarbituric acid
        4,5-dimethylaminobenzylidene-2-thiobarbituric acid
        5,5'-(salicylidene)bis-(2-thiobarbituric acid)
        5-((1-(2-bromobenzoyl)-5-chloro-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
        5-(2-thiophene)-2-thiobarbituric acid
        5-(4-(benzyloxy)-3-chlorobenzylidene)dihydro-2-thioxopyrimidine-4,6(1H,5H)-dione
        5-(4-vinylbenzyl)-2-thiobarbituric acid
        EiK1 compound
        ITBA-16
        PNR-3-80
        PNR-3-82

Experts

1.	Alamo, Cecilio: 1 article (12/2005)
2.	López-Muñoz, Francisco: 1 article (12/2005)
3.	Ucha-Udabe, Ronaldo: 1 article (12/2005)

Related Diseases

1.	Craniocerebral Trauma (Head Injury) 06/15/1997 - "This may be a substance-related effect of thiobarbiturates and it may be clinically important in barbiturate-sedated patients with severe head injury. "
2.	Epilepsy (Aura) 12/01/2005 - "We describe the role played in therapy by barbiturates throughout their history: their traditional use as sedative and hypnotic agents, their use with schizophrenic patients in so-called "sleep cures" (Klaesi, Cloetta), the discovery of the antiepileptic properties of phenobarbital (Hauptmann) and their use in the treatment of epilepsy, and the introduction of thiobarbiturates in intravenous anesthesia (Lundy, Waters). "
3.	Hypoxia (Hypoxemia) 11/01/1993 - "Biogenic amine metabolism in severe brain trauma has been analysed in 165 patients whose brain was protected from hypoxia with GOBA and thiobarbiturates in subnarcotic doses (116 cases) and the combination of the above agents with an early course of HBO (49 cases). "
4.	Anaphylaxis (Anaphylactic Shock) 09/01/1990 - "Twenty-seven patients were referred for evaluation of anaphylaxis after induction of general anesthesia (GA) in which thiobarbiturates, muscle relaxants, or antibiotics were administered intravenously. "
5.	Traumatic Brain Injuries (Traumatic Brain Injury) 11/01/1993 - "Biogenic amine metabolism in severe brain trauma has been analysed in 165 patients whose brain was protected from hypoxia with GOBA and thiobarbiturates in subnarcotic doses (116 cases) and the combination of the above agents with an early course of HBO (49 cases). "

Related Drugs and Biologics

1.	Phenobarbital (Luminal)
2.	Hypnotics and Sedatives (Sedatives)
3.	Biogenic Amines (Biogenic Amine)
4.	Barbiturates
5.	Anticonvulsants (Antiepileptic Drugs)
6.	Anti-Bacterial Agents (Antibiotics)
7.	barbituric acid (barbiturate)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Anesthesia
3.	General Anesthesia