Thiamine Triphosphate

3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,8,8-tetrahydroxy-3,5,7-trioxa-4,6,8-triphosphaoct-1-yl)thiazolium hydroxide, inner salt, P,P',P''-trioxide. The triphosphate ester of thiamine. In Leigh's disease, this compound is present in decreased amounts in the brain due to a metabolic block in its formation.

Also Known As:

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bettendorff, Lucien: 2 articles (01/2013 - 04/2004)
2.	Lakaye, Bernard: 2 articles (01/2013 - 04/2004)
3.	Wins, Pierre: 2 articles (01/2013 - 04/2004)
4.	Aleshin, Vasily: 1 article (12/2016)
5.	Artiukhov, Artem: 1 article (12/2016)
6.	Bunik, Victoria: 1 article (12/2016)
7.	Mkrtchyan, Garik: 1 article (12/2016)
8.	Gangolf, Marjorie: 1 article (01/2013)
9.	Gigliobianco, Tiziana: 1 article (01/2013)
10.	Pirson, Bastien: 1 article (01/2013)

Related Diseases

1.	Leigh Disease (Leigh's Disease) 12/01/1983 - "[Thiamin triphosphate and Leigh's disease]." 05/01/1972 - "Role of thiamine triphosphate in subacute necrotizing encephalomyelopathy." 04/04/1969 - "Thiamine triphosphate deficiency in subacute necrotizing encephalomyelopathy." 08/01/1976 - "The author suggests that the histologic changes of Leigh's disease, as well as the similar changes of Wernicke's disease, could be due to a deficiency of cerebral thiamine triphosphate." 11/01/1975 - "Analysis of five brains from patients with Leigh's disease demonstrates an accumulation of thiamine pyrophosphate and a deficiency of thiamine triphosphate. "
2.	Thiamine Deficiency 10/01/1975 - "Peripheral nerves are not invariably involved in patients with this disease, but as they are involved in thiamine-deficiency states it is conjectured that the presence or absence of peripheral neuropathy in patients with subacute necrotising encephalopathy may distinguish those with thiamine triphosphate deficiency from those in whom the disease is due to other causes." 07/01/1984 - "Content of thiamine triphosphate (TTP) was studied in rat liver tissue under conditions of normal state, thiamine deficiency and after loading with thiamine. " 01/01/1995 - "Thiamine phosphate esters (thiamine monophosphate-TMP; thiamine diphosphate-TDP and thiamine triphosphate-TTP) were measured as their thiochrome derivatives by High Performance Liquid Chromatography in the brains of pyrithiamine-treated rats at various stages during the development of thiamine deficiency encephalopathy. "
3.	Starvation 01/01/2013 - "coli, thiamine triphosphate (ThTP), a putative signaling molecule, transiently accumulates in response to amino acid starvation. " 04/23/2004 - "Thiamine triphosphate, a new signal required for optimal growth of Escherichia coli during amino acid starvation." 12/14/2016 - "The thiamine-dependent regulation of GDH is in good agreement with the fact that the non-coenzyme forms of thiamine, i.e., thiamine triphosphate and its adenylated form are generated in response to amino acid and carbon starvation."
4.	Brain Diseases (Brain Disorder) 10/01/1975 - "Peripheral nerves are not invariably involved in patients with this disease, but as they are involved in thiamine-deficiency states it is conjectured that the presence or absence of peripheral neuropathy in patients with subacute necrotising encephalopathy may distinguish those with thiamine triphosphate deficiency from those in whom the disease is due to other causes." 01/01/1995 - "Thiamine phosphate esters (thiamine monophosphate-TMP; thiamine diphosphate-TDP and thiamine triphosphate-TTP) were measured as their thiochrome derivatives by High Performance Liquid Chromatography in the brains of pyrithiamine-treated rats at various stages during the development of thiamine deficiency encephalopathy. "
5.	Wernicke Encephalopathy (Wernicke's Encephalopathy) 08/01/1976 - "The author suggests that the histologic changes of Leigh's disease, as well as the similar changes of Wernicke's disease, could be due to a deficiency of cerebral thiamine triphosphate."

Related Drugs and Biologics

1.	Thiamine (Aneurin)
2.	Thiamine Pyrophosphate
3.	thiamine triphosphorate (TTP)
4.	Amino Acids
5.	Phosphates (Orthophosphate)
6.	Esters
7.	Coenzymes (Enzyme Cofactors)
8.	Vitamins
9.	Thymidine Monophosphate (TMP)
10.	Thiamine Monophosphate