Thiamine Pyrophosphate

The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.

Also Known As:

Berolase; Pyrophosphate, Thiamine; Cocarboxylase; Thiamine Diphosphate; Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, P,P'-dioxide

Networked: 316 relevant articles (12 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Suleyman, Halis: 9 articles (09/2016 - 12/2012)
2.	Cetin, Nihal: 7 articles (09/2016 - 12/2012)
3.	Altuner, Durdu: 6 articles (09/2016 - 12/2012)
4.	Zhong, Chunjiu: 5 articles (01/2021 - 01/2016)
5.	Suleyman, Bahadir: 5 articles (09/2016 - 12/2012)
6.	Cinici, Emine: 4 articles (12/2020 - 01/2016)
7.	Sang, Shaoming: 4 articles (09/2018 - 01/2016)
8.	Sener, Ebru: 4 articles (09/2016 - 12/2012)
9.	Akcay, Fatih: 4 articles (01/2014 - 12/2012)
10.	Ahiskali, Ibrahim: 3 articles (01/2019 - 06/2016)

Related Diseases

1.	Hepatitis 07/01/1989 - "[Thiamine diphosphate pool and its biosynthesis in the liver in galactosamine hepatitis]." 02/01/1966 - "[Acute atrophy of the liver due to viral hepatitis treated by coenzyme A, alpha-lipoic acid, D.P.N and cocarboxylase]." 04/01/1969 - "[Influence of coenzyme A, nicotinamide adenine dinucleotide (NAD), alpha-lipoic acid and cocarboxylase on acute hepatitis (double blind experiment)]." 08/15/1985 - "In the present study the efficacy of two different cofactor regimens (coenzyme A, NAD, alpha lipoic-acid, cocarboxylase) in rats with fulminant galactosamine hepatitis were tested. " 08/15/1985 - "Effect of coenzyme-A, NAD, alpha lipoic-acid and cocarboxylase on survival of rats with galactosamine-induced severe hepatitis."
2.	Optic Nerve Diseases (Optic Neuropathy) 01/01/2019 - "We aimed to determine the protective effects of thiamine pyrophosphate on ethanol induced optic neuropathy in an experimental model. " 01/01/2019 - "Clinical studies are warranted to define the exact role of thiamine pyrophosphate in prevention of ethanol induced optic neuropathy." 01/01/2016 - "Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats." 01/01/2016 - "To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. "
3.	Type 2 Diabetes Mellitus (MODY) 01/01/2020 - "Thiamine pyrophosphate improved vascular complications of diabetes in rats with type 2 diabetes by reducing glycation, oxidative stress, and inflammation markers." 01/01/2020 - "Thus, in this study, the effect of thiamine pyrophosphate (TPP) on the in vivo and in vitro formation of glycation, oxidative stress, and inflammatory markers (the main contributors of vascular diabetes complications) was examined in type 2 diabetes rat model. "
4.	Diabetes Mellitus 02/01/1979 - "[Effect of cocarboxylase on the coagulogram indices in diabetes mellitus]." 07/01/1963 - "[EFFECT OF THIAMINE DIPHOSPHATE ON LIPID METABOLISM IN PATIENTS WITH DIABETES MELLITUS]." 02/01/1960 - "[Combined therapeutic action of cocarboxylase with B-Z 55, and D-860 in diabetes mellitus]." 12/05/1953 - "[Cocarboxylase in the treatment of diabetes mellitus]." 10/31/1953 - "[Therapeutic mechanism of cocarboxylase in diabetes mellitus in relation to the citric acid cycle]."
5.	Brain Diseases (Brain Disorder) 10/01/1954 - "[Very grave myocardosis with complex arrhythmia and bronchopulmonitis in a diabetic woman and a case of degenerative encephalopathy in a diabetic alcoholic treated successfully with cocarboxylase]." 08/01/2013 - "Characteristic feature of several neurodegenerating diseases including Alzheimer's disease and thiamine diphosphate deficiency encephalopathy is the decrease of PDHC activity correlating with cholinergic deficits and losses of cognitive functions. " 06/01/2021 - "Objectives: Zinc excitotoxicity and thiamine pyrophosphate deficiency (TD) are known pathogenic signals contributing to mechanism of different encephalopathies through inhibition of enzymes responsible for energy metabolism such as pyruvate dehydrogenase, aconitase or ketoglutarate dehydrogenase. " 01/01/1995 - "Thiamine phosphate esters (thiamine monophosphate-TMP; thiamine diphosphate-TDP and thiamine triphosphate-TTP) were measured as their thiochrome derivatives by High Performance Liquid Chromatography in the brains of pyrithiamine-treated rats at various stages during the development of thiamine deficiency encephalopathy. "

Related Drugs and Biologics

1.	Thiamine (Aneurin)
2.	Thiamine Pyrophosphate
3.	Enzymes
4.	Thioctic Acid (Lipoic Acid)
5.	Coenzyme A (CoA)
6.	NAD (NADH)
7.	Galactosamine
8.	Ethanol (Ethyl Alcohol)
9.	Insulin (Novolin)
10.	Thiamine Monophosphate

Related Therapies and Procedures

1.	Intravenous Injections
2.	Therapeutics
3.	Renal Dialysis (Hemodialysis)
4.	Transplantation
5.	Operative Surgical Procedures