Thiabendazole (Mintezol)

2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Also Known As:

Networked: 401 relevant articles (47 outcomes, 27 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rovellini, A: 3 articles (06/2007 - 12/2003)
2.	Bregani, E R: 3 articles (06/2007 - 12/2003)
3.	Tantardini, F: 2 articles (06/2007 - 06/2007)
4.	Tello, Raúl: 2 articles (10/2005 - 03/2002)
5.	Gotuzzo, Eduardo: 2 articles (10/2005 - 03/2002)
6.	Torres-Acosta, J F J: 1 article (09/2015)
7.	Villegas-Pérez, S L: 1 article (09/2015)
8.	Rodríguez-Vivas, R I: 1 article (09/2015)
9.	Chan-Pérez, J I: 1 article (09/2015)
10.	Soares, Neci Matos: 1 article (03/2014)

Related Diseases

1.	Infection 09/08/1979 - "Thiabendazole was highly effective in eradicating the infection. " 11/01/1984 - "Preliminary observations, using 5 rabbits carrying long-standing infections, indicated that single doses of thiabendazole were effective against adult O. " 02/01/1981 - "Thiabendazole was effective in eradicating the Strongyloides infection." 03/01/1966 - "The therapeutic efficacy of thiabendazole for helminthic infections in man; a literature review." 07/01/1982 - "With low-dose, long-term interrupted courses of thiabendazole treatment, the Strongyloides infection finally seemed to be cured."
2.	Strongyloidiasis 01/01/1965 - "Successful therapy of Strongyloidiasis with thiabendazole." 05/01/1981 - "When administered in time, thiabendazole, the drug of choice for strongyloidiasis, was effective in 70% of cases. " 03/01/1991 - "[New trial with thiabendazole for treatment of human strongyloidiasis]." 11/06/1965 - "[Contribution to the study of the therapy of human strongyloidiasis with thiabendazole (MK-360)]." 12/01/2004 - "Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases. "
3.	Larva Migrans (Cutaneous Larva Migrans) 10/01/1999 - "We found topical thiabendazole to be fast and effective in treating this case of cutaneous larva migrans of six months' duration." 07/01/1971 - "[Larva migrans: therapeutic trials with thiabendazole]." 11/01/2001 - "Treatment of widespread cutaneous larva migrans with thiabendazole." 09/01/2000 - "Efficacy and tolerability of thiabendazole in a lipophil vehicle for cutaneous Larva migrans." 12/15/1980 - "Because systemic thiabendazole therapy is frequently associated with toxic side effects, topical application seems to be the treatment of choice for creeping eruption caused by nematodes."
4.	Body Weight (Weight, Body) 01/01/1990 - "The steers were randomly assigned to groups fed the following: (1) endophyte fungus-infested fescue hay; (2) ammoniated endophyte fungus-infested fescue hay; (3) endophyte fungus-infested fescue hay plus 1 g of thiabendazole (TBZ)/9.1 kg of body weight at 7-day intervals; (4) ammoniated endophyte fungus-infested fescue hay plus 1 g of TBZ/9.1 kg at 7-day intervals; (5) ground Bermuda grass hay; and (6) endophyte-fungus-free fescue hay. " 10/01/1986 - "Under these environmental conditions and apparently low parasitism in this herd, thiabendazole did not substantially influence nematode egg count and had no effects on body weight gains or milk production." 10/01/1986 - "The anthelmintic, thiabendazole (6.6 g/100 kg body weight), was administered orally as a paste at 2.5, 3.5, 6, 9, and 14 mo of age and at parturition. " 10/01/1980 - "Five lambs were treated with thiabendazole (66 mg/kg of body weight) and 5 were untreated controls. " 10/01/1978 - "The treatment consisted of 25 mg Mintezol/kg body weight/day."
5.	Trichinellosis 11/01/1969 - "This study has failed to show any definite effect of thiabendazole on the course of human trichinosis at the doses used. " 04/01/1993 - "It can be concluded that treatment with Mintezol and 5-fluorouracil-Endoxan in trichinellosis represents a certain danger. " 07/01/1977 - "[Clinical and anatomopathological investigation in the treatment of acute trichinosis with thiabendazole (author's transl)]." 11/01/1969 - "Therapy in trichinosis with observations on the use of thiabendazole." 11/01/1969 - "Thiabendazole for the treatment of trichinosis in humans."

Related Drugs and Biologics

1.	Ivermectin (Mectizan)
2.	Mebendazole (Vermin)
3.	Levamisole (Decaris)
4.	Albendazole (Albenza)
5.	Thiabendazole (Mintezol)
6.	Pyrantel Pamoate (Pyrantel Embonate)
7.	Anthelmintics
8.	Morantel
9.	Benzimidazoles
10.	phenothiazine

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Perioperative Period
4.	Transplants (Transplant)
5.	Transplantation (Transplant Recipients)