Thermolysin

01/01/2023 - "The thermolysin digest also improved cognitive decline after oral administration in mice. "

11/01/2018 - "Similarly rapid autolysis of thermolysin mediated by DAIP was only observed upon the addition of amphiphilic compounds, which probably amplify the induced structural changes. "
06/01/2007 - "Co(2+) ion inhibits thermolysin activity not only as a competitive inhibitor but also promoting the autolysis."
06/01/2007 - "On the other hand, the Co(2+)-dependent inactivation in the Ca(2+)-sensitive part observed at [Ca(2+)] <0.5 mM proceeds time-dependently following second-order kinetics, and the time-course is in good agreement with that of decrease in the thermolysin band due to autolysis in SDS-PAGE. "
12/01/1986 - "High molecular weight autolysis products from thermolysin have been isolated and identified. "
04/15/1986 - "Autolysis of thermolysin. "

01/01/1983 - "By fingerprint analysis of the CEA digested with thermolysin, we could demonstrate differences between the two lung tumor CEA bands and the colonic tumor CEA. "
05/01/2008 - "Thermolysin treatment of tumor tissue liberated single cells from the tissue and allowed infection with ISVPs, but this did not result in the production of infectious virus particles. "
08/01/2000 - "DU-257 was condensed to the PEG-dipeptidyl linker through carboxyl terminal of dipeptide, and enzymatic release of DU-257 using a model enzyme, thermolysin, similar enzyme of which was shown to be overexpressed at various tumor sites, was evaluated by HPLC analysis. "
03/14/2023 - "In this study, we examine the effects of injectable liberase (a blend of collagenase and thermolysin enzymes) treatments on the linear and nonlinear rheology of allograft 4T1 mouse mammary tumors. "
10/03/2000 - "When segment B was derivatized to have an amino residue and then linked to PEG through a dipeptide, segment B was cleaved at the peptide bond by a particular enzyme, thermolysin (EC 3.4.24.4), but not by plasmin (EC 3.4.2 1.7.), indicating that certain protease specifically expressed at the tumor site would be capable of peptide-specific digestion and release of anti-tumor agent since a thermolysin-like enzyme has been reported to be expressed at many tumor cells. "

05/01/2008 - "Thermolysin treatment of tumor tissue liberated single cells from the tissue and allowed infection with ISVPs, but this did not result in the production of infectious virus particles. "
08/01/2005 - "Unlike native MccJ25, a thermolysin-cleaved MccJ25 variant was unable to bind to FhuA and failed to prevent phage T5 infection of E. "
09/01/2018 - "Based on the assumption that leptospiral proteases play a crucial role during infection, the aim of this work was to obtain a functional recombinant thermolysin for future studies on the role of these metalloproteases on leptospiral infection. "

10/01/2007 - "Molecular profiling of ovine prion diseases by using thermolysin-resistant PrPSc and endogenous C2 PrP fragments."
02/01/2007 - "Use of thermolysin in the diagnosis of prion diseases."
12/01/2008 - "Detection of PK-sensitive isoforms of disease-related PrP using thermolysin should be useful for improving diagnostic sensitivity in human prion diseases."
02/01/2007 - "Here, we have applied the protease thermolysin to the diagnosis of animal prion diseases. "