Thenoyltrifluoroacetone

Chelating agent and inhibitor of cellular respiration.

Also Known As:

4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione; TTFA cpd; Trifluorothienylacetone; 1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)-

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Butanones
    - Thenoyltrifluoroacetone: 9
      - thiothenoyltrifluoroacetone
- Sulfur Compounds: 278
  - Thiophenes: 257
    - Thenoyltrifluoroacetone: 9
      - thiothenoyltrifluoroacetone
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - Thenoyltrifluoroacetone: 9
      - thiothenoyltrifluoroacetone

Experts

1.	Gogvadze, Vladimir: 2 articles (08/2021 - 01/2016)
2.	Zhivotovsky, Boris: 2 articles (08/2021 - 01/2016)
3.	Abdrakhmanov, Alibek: 1 article (08/2021)
4.	Kaminskyy, Vitaliy O: 1 article (08/2021)
5.	Yapryntseva, Maria A: 1 article (08/2021)
6.	Belyaeva, Elena A: 1 article (12/2018)
7.	Kruspig, Björn: 1 article (01/2016)
8.	Skender, Belma: 1 article (01/2016)
9.	Valter, Kadri: 1 article (01/2016)
10.	Jee, Byul A: 1 article (10/2015)

Related Diseases

1.	Hypoxia (Hypoxemia) 08/10/2021 - "Targeting mitochondria with thenoyltrifluoroacetone (TTFA), an inhibitor of Complex II in the respiratory chain, stimulated cisplatin-induced apoptosis in various cell lines in normoxia but not in hypoxia. " 05/01/2008 - "In contrast, when BSMCs were exposed to hypoxic stress caused by CoCl2 or thenoyltrifluoroacetone (TTFA), substantial upregulation of GRP78 and CHOP was observed, suggesting involvement of hypoxia in the induction of ER stress. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 10/01/2015 - "To address the role of transcriptomic regulation by mitochondrial defects in liver cancer cells, we performed gene expression profiling for three different cell models of mitochondrial defects: cells with chemical respiratory inhibition (rotenone, thenoyltrifluoroacetone, antimycin A, and oligomycin), cells with mitochondrial DNA depletion (Rho0), and liver cancer cells harboring mitochondrial defects (SNU354 and SNU423). "
3.	Neuroblastoma 01/01/2016 - "Here we demonstrate how non-toxic doses of the mitochondrial Complex II inhibitor thenoyltrifluoroacetone (TTFA), which specifically inhibits the ubiquinone-binding site of succinate dehydrogenase (SDH), synergistically stimulated cell death, induced by harmless doses of cisplatin in a panel of chemoresistant neuroblastoma cell lines. "
4.	Neoplasms (Cancer) 10/05/2023 - ": AREs: antioxidant response elements; CHC: α-cyano -4-hydroxycinnamic acid; Chr: chromosome; CMA: chaperone-mediated autophagy; CT: control; DMF: dimethyl fumarate; Emi: endosomal microautophagy; HG: high-glucose; HMOX1: heme oxygenase 1; H2O2: hydrogen peroxide; KFERQ: lysine-phenylalanine-glutamate-arginine-glutamine; LAMP1: lysosomal associated membrane protein 1; LAMP2A: lysosomal associated membrane protein 2A; MCC: Manders' correlation coefficient; Manders' correlation coefficient Mo: morpholino oligonucleotide; NAC: N-acetyl cysteine; NFE2L2/NRF2: NFE2 like bZIP transcription factor 2; PA-mCherry: photoactivable mCherry; PCC: Pearson's correlation coefficient; ROS: reactive oxygen species; RT: rainbow trout; siRNAs: small interfering RNAs; SOD: superoxide dismutase; Tsg101: tumor susceptibility 101; TTFA: 2-thenoyltrifluoroacetone; WGD: whole-genome duplication."
5.	Liver Neoplasms (Liver Cancer) 10/01/2015 - "To address the role of transcriptomic regulation by mitochondrial defects in liver cancer cells, we performed gene expression profiling for three different cell models of mitochondrial defects: cells with chemical respiratory inhibition (rotenone, thenoyltrifluoroacetone, antimycin A, and oligomycin), cells with mitochondrial DNA depletion (Rho0), and liver cancer cells harboring mitochondrial defects (SNU354 and SNU423). "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Rotenone
3.	Oligomycins
4.	Glucose (Dextrose)
5.	Cisplatin (Platino)
6.	mesoxalonitrile
7.	Morpholinos
8.	Lysosomal-Associated Membrane Protein 1
9.	Lysosomal Membrane Proteins
10.	Heme Oxygenase-1