Thalamic Diseases

Disorders of the centrally located thalamus, which integrates a wide range of cortical and subcortical information. Manifestations include sensory loss, MOVEMENT DISORDERS; ATAXIA, pain syndromes, visual disorders, a variety of neuropsychological conditions, and COMA. Relatively common etiologies include CEREBROVASCULAR DISORDERS; CRANIOCEREBRAL TRAUMA; BRAIN NEOPLASMS; BRAIN HYPOXIA; INTRACRANIAL HEMORRHAGES; and infectious processes.

Also Known As:

Networked: 26 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Postherpetic Neuralgia
3.	Spinal Cord Injuries (Spinal Cord Injury)
4.	Neuralgia (Stump Neuralgia)
5.	Complex Regional Pain Syndromes

Experts

1.	Mammis, Antonios: 1 article (01/2017)
2.	Ward, Max: 1 article (01/2017)
3.	Assarzadegan, Farhad: 1 article (01/2015)
4.	Beladimoghadam, Nahid: 1 article (01/2015)
5.	Gharagozli, Kourosh: 1 article (01/2015)
6.	Hesami, Omid: 1 article (01/2015)
7.	Mansouri, Behnam: 1 article (01/2015)
8.	Sistanizad, Mohammad: 1 article (01/2015)
9.	Arita, Kazunori: 1 article (01/2014)
10.	Hanada, Tomoko: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thalamic Diseases:

1.	Chlorpromazine (Thorazine)FDA Link 10/05/1959 - "[A case of thalamic syndrome treated successfully with largactil]." 01/01/1957 - "[Thalamic syndrome with facial neuralgia; treatment by chlorpromazine]."
2.	Yi-Gan SanIBA 10/01/2009 - "We reported the efficacy of Yokukansan in patients with neuropathic pain, including acute herpetic pain, postherpetic neuralgia, central poststroke pain, post-traumatic spinal cord injury pain, thalamic syndrome, complex regional pain syndrome and symptomatic trigeminal neuralgia. "
3.	Naloxone (Narcan)FDA LinkGeneric 04/02/1988 - "Increasing doses of naloxone hydrochloride by infusion to treat pain due to the thalamic syndrome." 02/01/1992 - "Intravenous naloxone has been claimed to produce pain relief in opioid-resistant central post-stroke pain (CPSP, 'thalamic syndrome'). " 02/01/1985 - "Thirteen adult patients with established thalamic syndrome, resistant to prior analgesic and other therapy, were treated with intravenous infusions of the opiate antagonist, naloxone. "
4.	Analgesics (Analgesic Drugs)IBA 08/01/2002 - "An infarction or haemorrhage thalamic lesion can develop somatosensory disturbances and/or central pain in the opposite hemibody, analgesic or purely algesic thalamic syndrome characterised by contralateral anaesthesia (or hypaesthesia), contralateral weakness, ataxia and, often, persistent spontaneous pain. " 02/01/1985 - "Thirteen adult patients with established thalamic syndrome, resistant to prior analgesic and other therapy, were treated with intravenous infusions of the opiate antagonist, naloxone. "
5.	Opiate AlkaloidsIBA 02/01/1985 - "Thirteen adult patients with established thalamic syndrome, resistant to prior analgesic and other therapy, were treated with intravenous infusions of the opiate antagonist, naloxone. "
6.	Indicators and Reagents (Reagents)IBA 09/01/1994 - "CT evidence of a paramedian or anterolateral thalamic lesion might be an indicator for the development of central pain, because these types of infarctions occurred only in patients with the classic thalamic syndrome or the pure algetic thalamic syndrome. "
7.	Glucose (Dextrose)FDA LinkGeneric 03/01/1988 - "Regional brain glucose metabolism was studied in a case of postischaemic thalamic syndrome. " 03/01/1988 - "Brain glucose metabolism in thalamic syndrome."
8.	Disulfiram (Antabuse)FDA Link 04/01/1977 - "If this is so, then some other toxic effects of carbon disulfide, including parkinsonism, choreoathetosis, and thalamic syndrome may follow the ingestion of more than 5 g of disulfiram by adults, and individuals receiving as little as 125 mg of disulfiram per day may be at a three- to four-fold greater risk for arteriosclerotic cardiovascular disease than a comparable population not receiving the drug."
9.	CortisoneFDA Link 06/01/1957 - "Thalamic syndrome due to cerebral embolism in rheumatic heart disease; successful treatment with cortisone."
10.	Codon (Codons)IBA 01/01/2008 - "Familial Creutzfeldt-Jakob Disease with a codon 200 mutation presenting as thalamic syndrome: diagnosis by single photon emission computed tomography using (99m)Tc-ethyl cysteinate dimer."

Therapies and Procedures

1.	Therapeutics 01/01/2014 - "These results suggest that this model might be proved as a useful animal model for studying the neuropathology of thalamic syndrome, and developing improved therapeutics for CPSP. " 01/01/2011 - "Acupuncture as adjuvant therapy in thalamic syndrome: case report." 06/01/1981 - "The sensitivity to light, delayed onset, response to therapy, and presence of a thalamic lesion are analogous to the thalamic pain syndrome and suggest that central dazzle is a variant of the thalamic syndrome." 01/01/2011 - "The objective of this report was to demonstrate the use of electroacupuncture as adjuvant in the treatment of central pain, diagnosed as thalamic syndrome difficult to control with pharmacologic therapy. " 06/16/2009 - "This thalamic hemorrhage model is useful for studying the neuropathology and physiology of thalamic syndrome, and developing therapeutics for central post-stroke pain."
2.	Deep Brain Stimulation 01/01/2017 - "Deep Brain Stimulation for the Treatment of Dejerine-Roussy Syndrome." 08/01/2011 - "Deep brain stimulation for Dejerine-Roussy syndrome: case report."
3.	Anesthesia 07/01/1975 - "Good response was obtained in four patients with anesthesia dolorosa, four with thalamic syndrome, and one with paraplegic pain. " 01/01/1994 - "The pain was related to structural spinal disorders (4), postherpetic neuralgia (2), spinal cord injury (1), thalamic syndrome (1), anesthesia dolorosa of the face (1), and brainstem infarction (1). "
4.	Spinal Cord Stimulation 03/01/2004 - "We present a case of conversion disorder masquerading as Dejerine-Roussy syndrome after spinal cord stimulation. " 03/01/2004 - "Conversion disorder mimicking Dejerine-Roussy syndrome (thalamic stroke) after spinal cord stimulation."
5.	Laser Therapy (Surgery, Laser) 01/01/1986 - "[Laser therapy of post-stroke Déjérine-Roussy thalamic syndrome]."