Tetraisopropylpyrophosphamide

N,N',N'',N'''-Tetraisopropylpyrophosphamide. A specific inhibitor of pseudocholinesterases. It is commonly used experimentally to determine whether pseudo- or acetylcholinesterases are involved in an enzymatic process.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	El-Mezayen, Hatem A: 1 article (02/2016)
2.	Ghanem, Manal M E: 1 article (02/2016)
3.	Ghazy, Abd-El-Hady M: 1 article (02/2016)
4.	Ibrahim, Nihal M: 1 article (02/2016)
5.	Mahdy, El-Sayed M E: 1 article (02/2016)
6.	Mohamed, Magda A: 1 article (02/2016)
7.	Olafson, Pia U: 1 article (08/2010)
8.	Pruett, John H: 1 article (08/2010)
9.	Temeyer, Kevin B: 1 article (08/2010)

Related Diseases

1.	Pain (Aches) 02/01/2016 - "The substrate specificity, the relative efficiency of substrates hydrolysis, substrate inhibition and inhibition by BW284C51, but not by iso-OMPA, clearly indicated that they are true AChEs; their properties are compared with those recorded for insects as target hosts for H. " 12/15/1997 - "They were highly sensitive to inhibition by the AChE-specific inhibitor bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide, with inhibitor concentration reducing initial activity by 50% (IC50) between 0.1 and 0.8 microM, but activity was unaffected by tetramonoisopropylpyrophosphortetramide (iso-OMPA) at concentrations up to 10 mM. We conclude that the secreted enzymes are authentic AChEs of hydrophilic monomeric (G1) form and broadly similar properties, but which can be distinguished by molecular mass, inhibitor sensitivities and the degree of excess substrate inhibition." 08/27/2010 - "Biochemical characterization of the recombinant proteins supports classification of rBmAChE1, rBmAChE2, and rBmAChE3 as AChEs (E.C.3.1.1.7), as evidenced by (i) substrate preference for acetylthiocholine, (ii) inhibition by eserine, BW284c51, and the organophosphates (OPs) malaoxon and paraoxon, (iii) insensitivity to iso-OMPA, and (iv) rapid hydrolysis of acetyl-beta-methyl-thiocholine. "
2.	Ganglion Cysts (Ganglion) 10/01/1974 - "Transmural stimulation with 1-50 pulses (0.2-0.4 ms at 10 Hz) elicited graded twitches which were abolished by tetrodotoxin and were therefore neurogenic; longer pulses sometimes triggered tetrodotoxin-resistant myogenic contractions.2 Twitches elicited by 0.2-0.4 ms pulses were due to post-ganglionic excitation because they were not reduced by hexamethonium, pentolinium or dimethyltubocurarine, or by ganglion-paralyzing concentrations of nicotine.3 The acetyl- and butyryl-cholinesterase activities of the rectococcygeus were determined manometrically and could be selectively inhibited by BW 284C51 (1:5-bis-(4-allyl-dimethylammonium-phenyl)-pentan-3-one dibromide) and iso-OMPA (tetramonoisopropylpyrophosphortetramide), respectively. "
3.	Neuromuscular Diseases (Neuromuscular Disease) 07/01/1983 - "Acetylcholinesterase (AChE) activity was measured in the presence of the specific inhibitor of pseudocholinesterase, iso-OMPA, in plasma from patients with amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), neuromuscular disease controls, and normal controls. "
4.	Neoplasms (Cancer) 02/15/1988 - "In sucrose gradients, ChE sedimented as 12S in controls whereas in tumor serum samples from treated patients an additional component of 6 to 7 S, inhibited by both iso-OMPA and BW, also was detected. " 02/15/1988 - "Tumor serum ChE exhibited elevated sensitivity to 1,5-bis-(4-allyldimethyl ammonium phenyl)-pentan-3-one dibromide (BW), the selective bisquaternary inhibitor of "true" acetylcholinesterase (AChE), with no correlation to age, sex, staging of tumor, presence of metastases or the specific treatment protocol, and with a different distribution pattern from the decrease in ChE specific activity or the sensitivity to iso-OMPA. "
5.	Neoplasm Metastasis (Metastasis) 02/15/1988 - "Tumor serum ChE exhibited elevated sensitivity to 1,5-bis-(4-allyldimethyl ammonium phenyl)-pentan-3-one dibromide (BW), the selective bisquaternary inhibitor of "true" acetylcholinesterase (AChE), with no correlation to age, sex, staging of tumor, presence of metastases or the specific treatment protocol, and with a different distribution pattern from the decrease in ChE specific activity or the sensitivity to iso-OMPA. "

Related Drugs and Biologics

1.	Dibromide 4,4'- (3- oxo- 1,5- pentanediyl)bis(N,N- dimethyl- N- 2- propenyl- ) Benzenaminium
2.	Acetylcholinesterase
3.	Butyrylcholinesterase
4.	Hexamethonium (Hexamethonium Bromide)
5.	Thiocholine
6.	Tetrodotoxin (Tetradotoxin)
7.	Sucrose (Saccharose)
8.	Recombinant Proteins
9.	Physostigmine
10.	Organophosphates