Tetradecanoylphorbol Acetate

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

Also Known As:

12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; Tetradecanoylphorbol Acetate, 4a alpha-Isomer; 12 Myristoyl 13 acetylphorbol; 12 O Tetradecanoyl Phorbol 13 Acetate; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Acetate, Phorbol Myristate; Acetate, Tetradecanoylphorbol; Myristate Acetate, Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; Tetradecanoylphorbol Acetate, 4a alpha Isomer; Phorbol Myristate Acetate; Tetradecanoic acid, 9a-(acetyloxy)-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz(1,2-e)azulen-9-yl ester, (1aR-(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))-

Networked: 895 relevant articles (8 outcomes, 65 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Phorbols: 26
        Phorbol Esters: 2726
        Tetradecanoylphorbol Acetate: 895
        20-oxo-20-deoxy-12-myristate 13-acetate: 4
        12-O-hexadecanoylphorbol-13-acetate: 3
        phorbolol myristate acetate: 2
        2,3-dihydrophorbol myristate acetate: 1
        4-O-methyl-12-O-tetradecanoylphorbol 13-acetate: 1
        (5,6)PA
        12-O-(12(N)-dansylaminododecanoyl)phorbol 12,20-diacetate
        12-O-(12-N-dansylaminododecanoyl)phorbol
        12-O-tetradeca-2,4,6,8-tetranoylphorbol-13-acetate
        12-O-tetradecanoylphorbol-1,3-acetate
        O-(N-dansylamino-3-tetradecanoyl)-12,O-acetyl-13-phorbol

Experts

1.	Chen, Hsing I: 5 articles (03/2012 - 05/2003)
2.	Kim, Hyung-Min: 3 articles (07/2018 - 05/2002)
3.	Chu, Shi-Jye: 3 articles (12/2013 - 08/2004)
4.	Huang, Kun-Lun: 3 articles (12/2013 - 04/2008)
5.	Hong, Yong-Ki: 3 articles (01/2009 - 08/2007)
6.	Khan, Mohammed Nurul Absar: 3 articles (01/2009 - 08/2007)
7.	Park, Nam Gyu: 3 articles (01/2009 - 08/2007)
8.	Fujii, Hitoshi: 3 articles (07/2008 - 08/2007)
9.	Hsu, Kang: 3 articles (08/2004 - 05/2003)
10.	Wang, David: 3 articles (08/2004 - 05/2003)

Related Diseases

1.	Infections 12/01/2012 - "Phorbol myristate acetate-stimulated oxidative burst in HD11 cells was greatly impaired after infection by each of the five serovars. " 03/01/2010 - "We found that the release of ectosomes was not associated exclusively with mycobacterial infection since infection with other microorganisms (e.g., Leishmania mexicana, Staphylococcus aureus, and Escherichia coli or activation with phorbol myristate acetate (PMA)) also induced ectocytosis. " 03/16/2007 - "The potential biological relevance of the hBVR activation of PKC betaII was suggested by the finding that in cells transfected with the PKC betaII, hBVR augmented phorbol myristate acetate-mediated c-fos expression, and infection with sihBVR attenuated the response. " 07/01/2001 - "However, the production of O2- by macrophages was undetectable during the first 30 min following infection and no respiratory burst was inducible by phorbol myristate acetate (PMA) 4 h after infection with V. anguillarum. " 06/01/2001 - "Ad/t-PA infection of phorbol myristate acetate (PMA)-differentiated MEG-01 cells increased cellular t-PA levels by 120 fold (1580 +/- 130 ng/10(6) cells at 5 MOI) in comparison to non-or Ad/beta-gal-infected cells. "
2.	Acute Lung Injury 03/01/2012 - "Phorbol myristate acetate (PMA) is a strong neutrophil activator and has been used to induce acute lung injury (ALI). " 07/01/2008 - "Phorbol myristate acetate (PMA) causes acute lung injury (ALI). " 02/01/1999 - "A model of acute lung injury induced by intravenous phorbol myristate acetate (PMA) is described. " 01/01/1999 - "Phorbol myristate acetate (PMA) activates neutrophils and causes acute lung injury. " 02/01/1998 - "We investigated the hypothesis that NO opposes increases in pulmonary vascular permeability after phorbol myristate acetate administration, i.e., in a model of neutrophil-dependent acute lung injury. "
3.	Inflammation (Inflammations) 05/01/1994 - "Human peritoneal MO from inflammation-free patients reacted against a human tumour cell line if cultured with LPS and TPA (phorbol-myristate acetate) and were therapeutically effective against the same palpable s.c. " 10/01/1995 - "The present study was designed to test the hypothesis that ileal microvascular injury during phorbol myristate acetate (PMA)-induced systemic inflammation is also blocked by MoAB 60.3. " 06/01/2018 - "We aim to clarify whether the expression of NF-κB gene family affects inflammation caused by PM2.5. Human monocytic cells (THP-1) were induced to differentiate into macrophages using phorbol myristate acetate. " 01/01/2015 - "Using phorbol-myristate-acetate as an activator of inflammation, we investigated the effect on the developing rodent brain. " 12/01/2010 - "The most active synthetic compound 33 reduced phorbol myristate acetate (PMA)-induced inflammation in the mouse ear by 72% at 50 μg/ear. "
4.	Edema (Dropsy) 09/01/2021 - "This study aims to clarify an anti-inflammatory effect of CQ through modulating TSLP levels using an in vitro model of phorbol myristate acetate (PMA) + A23187-activated human mast cell line (HMC-1) and an in vivo model of PMA-irritated ear edema. " 10/01/1987 - "In a previous study, we demonstrated that a non-toxic concentration of phorbol myristate acetate (PMA) produced edema in isolated rat lungs which were coperfused with neutrophils (PMN). " 01/01/2019 - "This series of compounds were tested for their potential anti-inflammatory capacity in an in vivo murine model, and four compounds were identified to inhibit tetradecanoylphorbol acetate (TPA)-induced edema by more than 75 %. " 07/27/2012 - "The anti-inflammatory activity of 1-3 was evaluated by measuring their ability to reduce phorbol myristate acetate (PMA)-induced edema in a mouse ear model. " 08/11/2000 - "Mangicols A and B, however, showed significant antiinflammatory activity in the PMA (phorbol myristate acetate)-induced mouse ear edema model. "
5.	Asthma (Bronchial Asthma) 01/01/1994 - "Airspace cells from patients with mild asthma and those with moderate asthma had higher phorbol myristate acetate (PMA)-stimulated SO production when compared with those from normal subjects (8.9 +/- 0.7, 11.1 +/- 2.4, and 6.5 +/- 0.4 nmol/5 x 10(5) cells/hour respectively, p < 0.005, r = -0.35, both comparisons). " 02/01/1988 - "In asthma, eosinophil CL to zymosan, but not phorbol myristate acetate, was significantly less. " 11/01/2020 - "However, the inhibitory effect of DC on allergic inflammatory response remains unclear; therefore, the current study used an experimental ovalbumin (OVA)‑induced allergic asthma mouse model and phorbol myristate acetate (PMA)‑ and A23187‑stimulated HMC‑1 cells to reveal the effects of DC in regulating airway inflammation and its possible mechanism. " 02/01/2002 - "Heparinized blood samples were obtained from subjects with atopic asthma (n = 10), subjects with nonatopic asthma (n = 10), and healthy subjects (n = 10) and stimulated with ionomycin and phorbol myristate acetate in the presence of brefeldin A. " 07/01/1990 - "In contrast, no difference was observed in O2- production between normal- and low-density eosinophils from asthma patients when stimulated by phorbol myristate acetate (PMA) or the calcium ionophore A23187. "

Related Drugs and Biologics

1.	Zymosan
2.	Cytokines
3.	Interferon-gamma (Interferon, gamma)
4.	Tretinoin (Retinoic Acid)
5.	1,3-dimethylthiourea
6.	Arachidonic Acid (Vitamin F)
7.	Interleukin-4 (Interleukin 4)
8.	Ionomycin
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	N-Formylmethionine Leucyl-Phenylalanine

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Intravenous Injections
3.	Intravenous Infusions
4.	Aftercare (After-Treatment)
5.	Renal Dialysis (Hemodialysis)