Tetrachlorodibenzodioxin (TCDD)

A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.

Also Known As:

Networked: 1646 relevant articles (32 outcomes, 244 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tohyama, Chiharu: 28 articles (10/2014 - 01/2002)
2.	Peterson, Richard E: 22 articles (07/2015 - 08/2002)
3.	Matsumura, Fumio: 22 articles (05/2015 - 03/2002)
4.	Heideman, Warren: 16 articles (07/2015 - 11/2003)
5.	Pohjanvirta, Raimo: 15 articles (10/2015 - 04/2004)
6.	Mocarelli, Paolo: 14 articles (02/2014 - 07/2002)
7.	Safe, Stephen: 13 articles (09/2015 - 06/2002)
8.	Lawrence, B Paige: 13 articles (02/2014 - 06/2003)
9.	Zacharewski, Timothy R: 12 articles (12/2015 - 12/2004)
10.	Walker, Nigel J: 12 articles (11/2012 - 08/2002)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/1992 - "The results suggest that a single sublethal dose of TCDD does not alter markedly the general behaviour of Han/Wistar rats, in contrast to its striking effect on feeding behaviour which results in a marked decrease in body weight gain." 01/01/2009 - "The body weight of the 125-ng/kg TCDD group was significantly decreased relative to control and there was also a significant reduction in absolute and relative ovarian weights. " 09/20/1999 - "A repeated dose (5 microg/kg/day for 5 days) of TCDD also resulted in a significant reduction in body weight. " 11/01/1998 - "TCDD caused a reduction in the body weight gain of the dams in both dose groups and a significant reduction in litter size in the higher dose group. " 12/01/2014 - "In the present study, pregnant mice were dosed with TCDD 24 µg/kg and with or without FA 5 mg/kg body weight on gestation day 10. "
2.	Atrophy 01/01/2013 - "In the highest dose group (160 µg/Kg), TCDD treatment caused a significant reduction of parasite burdens by 10-fold after three weeks while also causing a significant lymphoid atrophy indicating suppression of the non-protective T helper 2 response. " 04/01/2005 - "Given the rapid clearance of apoptotic cells from the thymus, these histopathologic and cytometric data suggest increased thymocyte apoptosis contributes to fetal thymic atrophy after TCDD exposure." 01/01/1990 - "For example, hypergastrinemia does not develop within the first 48 hr after TCDD administration, and TCDD treatment affords no protection against fasting-induced atrophy of the oxyntic gland mucosa during this time. " 04/01/2013 - "The current study proved that administration of low TCDD dose (seven times lower than used in other studies) can cause thymus, spleen, or lymphatic gland atrophy. " 01/01/2012 - "In the current study, therefore, we investigated the effects of prenatal exposure to TCDD on miR profile in fetal thymocytes and searched for their possible role in causing thymic atrophy and alterations in the expression of apoptotic genes. "
3.	Neoplasms (Cancer) 02/15/2002 - "A significantly greater decrease in membrane-associated K-ras p21 and increase in total and membrane associated raf-1 occurred in the NDMA/TCDD tumors compared with the NDMA-only tumors. " 12/01/2011 - "The International Agency for Research on Cancer classified TCDD as a known human carcinogen, based on predominantly male occupational studies of increased mortality from all cancers combined. " 08/01/2011 - "Results of additional, smaller studies of other occupational groups potentially exposed to TCDD, and of community-based case-control studies, did not provide consistent evidence of an increased cancer risk. " 04/01/2011 - "The exact mechanisms of apoptosis inhibition by TCDD are not fully understood, but both in vivo and in vitro studies consistently showed an involvement of the tumor suppressor p53 in this effect. " 04/01/2011 - "In initiation-promotion studies, TCDD was shown to be a potent liver tumor promoter. "
4.	Edema 11/01/2004 - "In addition, in TCDD dose response studies the zfarnt2(-/-) embryos showed no protection against three endpoints of TCDD toxicity observed at 96 hpf: pericardial edema, reduced trunk blood flow, and shortened lower jaw. " 09/01/2014 - "In the present study, microscopic analysis with a high-speed camera revealed that TCDD increased the size of a small cavity between the heart and body wall in early eleutheroembryos, a toxic effect that we designate as precardiac edema. " 06/01/2008 - "Mortality, heart rates, edema severity, CYP1A, and regucalcin gene expressions were investigated to study TCDD-induced toxicity in zebrafish during the early life stage. " 07/01/1997 - "Larvae that developed generalized edema were collected at 7 days after the end of TCDD exposure for light and electron microscopic studies. " 09/01/2014 - "These results suggest a role of the COX2b-thromboxane pathway in precardiac edema formation following TCDD exposure in developing zebrafish."
5.	Hydronephrosis 10/01/2014 - "Although C57BL/6J and BALB/cA mice harbor AhR receptors highly responsive to TCDD, they were found by chance to differ significantly in the incidence of TCDD-induced hydronephrosis. " 06/01/2014 - "Histochemical staining indicated that Prx I protein was positively expressed in the ureteric epithelium in the treated group, and not in the control group, which is consistent with MALDI-TOF-MS. Prx I protein may be a potential biomarker or responsive protein of hydronephrosis in fetal mice induced by TCDD." 01/01/2014 - "Elucidation of the pathway leading to the onset of hydronephrosis using the TCDD-exposed mouse model will deepen our understanding of the molecular basis of nonobstructive hydronephrosis in humans. " 09/15/2008 - "These findings suggest an essential role of COX-2 in mediating the TCDD action of inducing hydronephrosis through the functional impairment rather than the anatomical blockade of the ureter." 09/15/2008 - "Here, we report that hydronephrosis induced in mouse pups exposed lactationally to TCDD is not associated with anatomical obstruction, but with abnormal alterations in the subepithelial mesenchyma of the ureter. "

Related Drugs and Biologics

1.	Tetrachlorodibenzodioxin (TCDD)
2.	Estrogens (Estrogen)
3.	Curcumin
4.	Vitamin E
5.	Succinic Acid (Succinate)
6.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Proteins (Proteins, Gene)
9.	Carbon Monoxide
10.	Vitamin A (Retinol)

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Oral Administration
3.	Homologous Transplantation (Allograft)
4.	Ligation
5.	Castration