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Tetrabenazine (Nitoman)

Subscribe to New Research on Tetrabenazine

A drug formerly used as an antipsychotic and treatment of various movement disorders. Tetrabenazine blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system.

Also Known As:

Nitoman; Cambridge Laboratories Brand of Tetrabenazine; Orphan Brand of Tetrabenazine; Roche Brand of Tetrabenazine; Shire Brand of Tetrabenazine; Xenazine; Tetrabenazine Orphan Brand; 2H-Benzo(a)quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-

Networked: 246 relevant articles (34 outcomes, 23 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Quinolizines: 1
    - Tetrabenazine: 246

Experts

1.	Jankovic, Joseph: 15 articles (04/2013 - 11/2002)
2.	Ondo, William G: 8 articles (08/2012 - 11/2002)
3.	Frank, Samuel: 6 articles (01/2014 - 05/2008)
4.	Hunter, Christine: 6 articles (02/2013 - 01/2007)
5.	Davidson, Anthony: 4 articles (02/2013 - 01/2007)
6.	Shoulson, Ira: 3 articles (01/2013 - 05/2008)
7.	Clarence-Smith, Kathleen: 3 articles (01/2013 - 01/2011)
8.	Kenney, Christopher: 3 articles (01/2007 - 01/2006)
9.	Yohn, Samantha E: 2 articles (02/2016 - 08/2015)
10.	Podurgiel, Samantha J: 2 articles (02/2016 - 08/2015)

Related Diseases

1.	Chorea (Rheumatic Chorea) 12/01/2011 - "The antichorea efficacy of tetrabenazine was maintained in an 80-week extension study (n = 75), with the adjusted mean UHDRS total maximum chorea score significantly (p < 0.001) reduced from baseline (score of 14.9) by 4.6 points (primary outcome). " 03/01/2015 - "On the basis of some research evidence and clinical experience, tetrabenazine may be effective in treating chorea. " 01/01/2012 - "This pilot study demonstrates tetrabenazine's potential effects beyond improvement in chorea." 01/01/2013 - "Tetrabenazine treatment was associated with long-term improvement in chorea. " 01/01/2013 - "Safety and Efficacy of Tetrabenazine and Use of Concomitant Medications During Long-Term, Open-Label Treatment of Chorea Associated with Huntington's and Other Diseases."
2.	Movement Disorders (Movement Disorder) 06/30/1979 - "Tetrabenazine produced moderate to marked improvement in the movement disorder in 79% of a series of 40 Australian patients. " 04/01/2011 - "Small trials indicate tetrabenazine may be effective for the treatment of tardive dyskinesia. " 04/01/1985 - "Although tetrabenazine masked symptoms in 5 of 7 patients to whom it was administered, none was able to achieve remission of tardive dyskinesia when taken off the drug. " 05/01/2013 - "As might be anticipated from its pharmacological profile, tetrabenazine has the potential to cause tardive dyskinesia. " 05/01/2013 - "Tardive dyskinesia caused by tetrabenazine."
3.	Dyskinesias (Dyskinesia) 04/01/1972 - "Tetrabenazine is an effective agent for the suppression of choreiform and ballistic involuntary movements. " 05/01/2013 - "Generalized choreiform dyskinesia developed after 10 months of conventional-dosage tetrabenazine treatment, persisting for several weeks after the drug was discontinued. " 01/01/2012 - "Dual treatment of hemichorea-hemiballismus syndrome with tetrabenazine and chemodenervation." 08/01/2009 - "Pelvic dyskinesia with an outstanding response to tetrabenazine." 07/01/2009 - "In one, abnormal movements persisted despite treatment with tetrabenazine. "
4.	Hyperkinesis 01/01/2008 - "In clinical studies, tetrabenazine has been found to be effective in a wide range of hyperkinetic movement disorders, including small numbers (<50) of patients with TS in some studies. " 01/01/1982 - "In a double-blind crossover trial of tetrabenazine versus placebo, 19 patients with a variety of hyperkinetic movement disorders were evaluated. " 04/01/2014 - "We assessed and characterized these hyperkinetic movements in detail and investigated the effect of tetrabenazine (TBZ) treatment. " 11/01/2013 - "VMAT2 is also a target of tetrabenazine, a drug used in the treatment of hyperkinetic movement disorders, including TD. " 07/01/2012 - "Tetrabenazine (TBZ) is a monoamine storage inhibitor that was first introduced in the 1970s for the management of hyperkinetic movement disorders. "
5.	Dystonia (Limb Dystonia) 06/01/2000 - "After three years of treatment for dystonia with tetrabenazine, a clear reduction in the frequency, intensity and duration of the crises was perceived. " 03/10/1996 - "One of the patients developed dystonia 24 hours after ingestion of 750 mg tetrabenazine in an attempt at suicide. " 03/01/1989 - "Mild improvement has occurred after 5 months' treatment with tetrabenazine despite the long duration of dystonia and the presence of secondary structural changes." 02/01/1986 - "Tetrabenazine and dystonia in primates." 12/01/2014 - "Both subjects showed marked improvement in myoclonus and mild-to-moderate improvement in dystonia with tetrabenazine. "

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Amantadine (Aman)
3.	Trihexyphenidyl (Artane)
4.	Clonidine (ST 155)
5.	phenothiazine
6.	Haloperidol (Haldol)
7.	Dopamine Receptors (Dopamine Receptor)
8.	Antipsychotic Agents (Antipsychotics)
9.	Levodopa (L Dopa)
10.	Botulinum Toxins (Botulinum Toxin)

Related Therapies and Procedures

1.	Injections
2.	Aftercare (After-Treatment)
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Induced Hypothermia