Testolactone (Teslac)

06/01/1997 - "Precocious puberty was treated initially with testolactone and later with oophorectomy. "
01/01/2004 - "The first-generation agent, testolactone, has been demonstrated to be tolerable and effective in the treatment of familial male precocious puberty, while mixed results with testolactone have been achieved in girls with McCune-Albright syndrome. "
10/30/1986 - "We conclude that testolactone is an effective treatment of precocious puberty in the McCune-Albright syndrome."
06/01/1985 - "Testolactone treatment of precocious puberty in McCune-Albright syndrome."
01/01/2004 - "In conclusion, aromatase inhibitors, particularly testolactone, have a proven track record in the treatment of a few forms of precocious puberty. "

03/01/1998 - "Girls with McCune-Albright syndrome, given testolactone, respond similarly. "
06/01/1987 - "Short-term effects of testolactone compared to other treatment modalities on longitudinal growth and ovarian activity in a girl with McCune-Albright syndrome."
01/01/2004 - "The first-generation agent, testolactone, has been demonstrated to be tolerable and effective in the treatment of familial male precocious puberty, while mixed results with testolactone have been achieved in girls with McCune-Albright syndrome. "
10/30/1986 - "We conclude that testolactone is an effective treatment of precocious puberty in the McCune-Albright syndrome."
06/01/1985 - "Testolactone treatment of precocious puberty in McCune-Albright syndrome."

05/01/1981 - "These data suggest that Teslac may be an effective treatment for men with idiopathic oligospermia. "
05/01/1989 - "Subjects (n = 25) with infertility due to unexplained oligozoospermia were given testolactone (2 g/day) or placebo for 8 months followed by crossover to the other treatment for an additional 8 months. "
07/01/1987 - "In a pilot study, 13 subfertile men with idiopathic normogonadotropic oligozoospermia were treated by the aromatase inhibitor testolactone for a period of 6 months. "
01/01/1988 - "Tamoxifen and testolactone in therapy of oligozoospermia: results of a randomized study."
07/01/1987 - "[Long-term therapy of oligozoospermia with the aromatase inhibitor testolactone]."

01/01/2004 - "A favorable outcome with the use of testolactone in conjunction with conventional therapy in children with congenital adrenal hyperplasia has also been suggested. "
10/01/1996 - "A preliminary study of flutamide, testolactone, and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia."
07/01/2002 - "A new four-drug treatment regimen of flutamide, testolactone, reduced hydrocortisone dose, and 9alpha-fludrocortisone has been shown to achieve normal growth and development after 2 yr of therapy and may, therefore, represent a potential alternative approach to the treatment of children with classic congenital adrenal hyperplasia. "
03/01/2000 - "Flutamide, testolactone, and reduced hydrocortisone dose maintain normal growth velocity and bone maturation despite elevated androgen levels in children with congenital adrenal hyperplasia."
10/01/1996 - "We conclude that the regimen of flutamide, testolactone, reduced hydrocortisone does, and fludrocortisone improve the short term control of growth and bone maturation in children with congenital adrenal hyperplasia. "

01/01/2005 - "Treatment of the proband was more effective with anastrozole than with testolactone and increased the initially reduced testes volume to normal size, promoted virilization, and normalized serum estrone and testosterone levels. "
03/01/1998 - "A 2-yr-old female (case 1) on testolactone for non-McCune-Albright gonadotropin independent precocious puberty had marked elevations of androstenedione (18 ng/mL, normal: 0.2-3.1) and testosterone (3.6 ng/mL, normal < 0.2) but no virilization. "