Tenuazonic Acid

3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Motoyama, Takayuki: 3 articles (12/2021 - 11/2020)
2.	Osada, Hiroyuki: 2 articles (12/2021 - 12/2021)
3.	Yun, Choong-Soo: 2 articles (12/2021 - 12/2021)
4.	Chen, Shiguo: 2 articles (01/2021 - 03/2010)
5.	Qiang, Sheng: 2 articles (01/2021 - 03/2010)
6.	Marko, Doris: 2 articles (01/2016 - 12/2012)
7.	Kashiwa, Takeshi: 1 article (12/2021)
8.	Yoshida, Kazuko: 1 article (12/2021)
9.	Brunetti, Leonardo: 1 article (01/2021)
10.	Cardoso, Sandra M: 1 article (01/2021)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 01/22/2016 - "In this study, cytotoxic effects of binary mixtures of the Fusarium toxins enniatin B, aurofusarin, deoxynivalenol, nivalenol and zearalenone, and tenuazonic acid produced by Alternaria spp., were evaluated by the WST-1 assay in the colorectal carcinoma cell-line Caco-2 after 24h of incubation. "
2.	Dehydration (Water Stress) 01/01/2022 - "We show through in vivo gene deletion, in vitro biochemical assay and isotope labelling experiments that AvmM catalyzes tandem dehydration and Michael-type addition to generate the core scaffold of 1. Mechanistic studies by crystallography, DFT calculations and MD simulations of AvmM reveal that the reactions are achieved with assistance from the special tenuazonic acid like moiety of substrate. "
3.	Infections 12/22/2021 - "Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae." 02/02/2018 - "alternata infection also reduced tenuazonic acid (TA) production by 81.2 to 99.8%, finding TA levels similar to negative controls. " 02/02/2018 - "Isolation, identification and selection of antagonistic yeast against Alternaria alternata infection and tenuazonic acid production in wine grapes from Argentina." 09/15/2023 - "We show that MoMIF1 is secreted during plant infection, affects the production of the mycotoxin tenuazonic acid and inhibits plant cell death. " 01/01/2018 - "Results showed that the predominant toxin detected in all the samples was tenuazonic acid, the content of which was associated with the infection level; alternariol, alternariol monomethyl ether, and tentoxin were detected in all the infected samples and some of the uninfected samples with rather low contents."
4.	Neoplasms (Cancer) 12/09/1991 - "Inhibition of mouse skin tumor promotion by tenuazonic acid." 05/01/1967 - "Synthesis and anti-tumor activity of tenuazonic acid analogues."
5.	Necrosis 03/01/2010 - "Chloroplastic oxidative burst induced by tenuazonic acid, a natural photosynthesis inhibitor, triggers cell necrosis in Eupatorium adenophorum Spreng." 01/01/2021 - "The pathotype Ageratina adenophora secretes the non-host-selective toxin tenuazonic acid (TeA), which can cause necrosis in many plants. "

Related Drugs and Biologics

1.	Zearalenone
2.	Isotopes
3.	enniatins
4.	aurofusarin
5.	nivalenol
6.	deoxynivalenol
7.	Mycotoxins
8.	alternariol
9.	Polyketides
10.	Melanins (Melanin)