Tenosynovitis

Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.

Also Known As:

Networked: 274 relevant articles (24 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Synovitis
2.	Rheumatoid Arthritis
3.	Arthritis (Polyarthritis)
4.	Tendinopathy (Tendonitis)
5.	Tuberculosis (Tuberculoses)

Experts

1.	Bynum, Donald K: 3 articles (06/2012 - 11/2010)
2.	Draeger, Reid W: 3 articles (06/2012 - 11/2010)
3.	Naredo, Esperanza: 2 articles (09/2015 - 09/2012)
4.	Eshed, Iris: 2 articles (05/2015 - 08/2009)
5.	van der Heijde, Désirée: 2 articles (05/2015 - 03/2011)
6.	Østergaard, Mikkel: 2 articles (05/2015 - 05/2015)
7.	Lui, Tun Hing: 2 articles (03/2015 - 08/2007)
8.	Hernández-Díaz, Cristina: 2 articles (11/2014 - 12/2012)
9.	Yamamoto, Kei: 2 articles (07/2014 - 01/2013)
10.	Suzuki, Takeshi: 2 articles (03/2013 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tenosynovitis:

1.	TNFR-Fc fusion protein (etanercept)FDA Link 06/01/2010 - "Scores for tenosynovitis showed a significant reduction in the etanercept group compared with placebo (p=0.01) after 6 weeks of treatment. " 06/01/2010 - "Adding MRI joint synovitis to tenosynovitis scores gave an even higher significant reduction in the etanercept group (p=0.007). " 10/01/2002 - "Mycobacterium marinum tenosynovitis in a patient on etanercept therapy for rheumatoid arthritis." 02/01/2002 - "Effect of etanercept on tenosynovitis and nodules in rheumatoid arthritis." 06/01/2010 - "Rapid reduction in tenosynovitis of the wrist and fingers evaluated by MRI in patients with rheumatoid arthritis after treatment with etanercept."
2.	VaccinesIBA 09/01/1989 - "Efficacy of simultaneous administration of Marek's disease and viral tenosynovitis vaccines to day-old broiler chickens." 07/01/1983 - "In laboratory and field trials there did not appear to be any interference, because chickens vaccinated with both vaccines were effectively immunized against challenge with virulent Marek's disease virus or tenosynovitis virus when compared with unvaccinated chickens or chickens vaccinated with either HVT or tenosynovitis virus. " 10/01/1983 - "II. Trivalent vaccines in breeders not previously vaccinated with live Newcastle disease, infectious bursal disease, and tenosynovitis vaccines." 10/01/1983 - "Inactivated Newcastle disease (NDV), infectious bursal disease (IBDV), and viral arthritis/tenosynovitis (VA) viruses were incorporated into water-in-oil emulsion vaccines, either alone, in bivalent combinations, or in a trivalent vaccine. " 10/01/1983 - "Inactivated Newcastle disease (NDV), infectious bursal disease (IBDV), and viral arthritis/tenosynovitis (VA) viruses were incorporated into water-in-oil emulsion vaccines either alone, in bivalent combinations, or in a trivalent vaccine. "
3.	methylprednisolone acetate (Depo-Medrol)FDA LinkGeneric 06/01/2014 - "Efficacy of acupuncture versus local methylprednisolone acetate injection in De Quervain's tenosynovitis: a randomized controlled trial." 07/01/2010 - "This study was performed to compare the outcome of methylprednisolone acetate injection plus thumb spica cast versus cast alone for the treatment of de Quervain's tenosynovitis. " 07/01/2010 - "Methylprednisolone acetate injection plus casting versus casting alone for the treatment of de Quervain's tenosynovitis." 07/01/1991 - "Treatment of De Quervain's tenosynovitis with methylprednisolone acetate injection rapidly controls the signs and symptoms, does not lead to serious adverse reactions, and should be the preferred initial treatment." 07/01/1991 - "Fifty-six cases of De Quervain's tenosynovitis (in 55 patients) were treated with a "long-acting" corticosteroid, methylprednisolone acetate, and followed prospectively over a 4-year period. "
4.	adalimumab (Humira)FDA Link 05/01/2015 - "The tenosynovitis score at month 6 was significantly lower in the adalimumab group, 1.3 (0), than in the placebo group, 3.9 (2), Mann-Whitney: p<0.035. " 05/01/2011 - "Ultrasonography shows significant improvement in wrist and ankle tenosynovitis in rheumatoid arthritis patients treated with adalimumab." 05/01/2015 - "The findings suggest that addition of adalimumab is associated with further suppression of osteitis and tenosynovitis." 05/01/2015 - "A treat-to-target strategy with methotrexate and intra-articular triamcinolone with or without adalimumab effectively reduces MRI synovitis, osteitis and tenosynovitis and halts structural damage progression in early rheumatoid arthritis: results from the OPERA randomised controlled trial."
5.	Anti-Bacterial Agents (Antibiotics)IBA 11/17/2010 - "Furthermore, locally administered antibiotics may be effective for the treatment of pyogenic flexor tenosynovitis." 09/01/2015 - "As broad-spectrum antibiotics have changed the management of other infectious conditions, we must more closely evaluate consistent antibiotic use in pyogenic flexor tenosynovitis management. " 06/01/2012 - "Management of all but the earliest cases of pyogenic flexor tenosynovitis consists of intravenous antibiotics and surgical drainage of the sheath with open or closed irrigation. " 01/01/1987 - "The authors report 68 cases of bacterial tenosynovitis (BT) that is the largest international series dealing with this pathology since the introduction of antibiotics. " 01/01/2005 - "Historically, pyogenic flexor tenosynovitis has been treated with surgical debridement followed by hospitalization and administration of intravenous antibiotics. "
6.	GadoliniumIBA 06/01/2010 - "Clinical evaluation, blood tests, functional capacity evaluation and h-MRI were performed at the start of the investigation and at week 6. Tenosynovitis was evaluated on T1-weighted sequences with fat suppression after gadolinium as the presence of a peritendinous signal enhancement on axial images using a new method including wrist and finger tendons. " 05/01/2015 - "To evaluate whether intravenous gadolinium (Gd) contrast administration can be eliminated when evaluating synovitis and tenosynovitis in early arthritis patients, thereby decreasing imaging time, cost, and invasiveness. " 05/01/2015 - "• Eliminating gadolinium contrast administration results in low specificity for synovitis • For tenosynovitis, sensitivity is low without gadolinium contrast administration • Gadolinium contrast administration remains essential for evaluating synovitis and tenosynovitis in early arthritis." 03/01/2009 - "Synovitis and tenosynovitis was calculated using quantitative analysis including the degree and kinetics of enhancement of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). " 10/01/2007 - "Synovitis and tenosynovitis were calculated based on the number of enhancing voxels, initial rate of enhancement, and maximal enhancement of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). "
7.	Clarithromycin (Biaxin)FDA LinkGeneric 12/01/2004 - "We present a case of tenosynovitis of the hand due to Mycobacterium chelonae in a patient without a recognized penetrating injury, who was treated successfully with clarithromycin and antituberculous medications and without debridement. " 10/01/2000 - "Sixteen months antibiotic regimen of rifabutin and clarithromycin led to a complete resolution of the tenosynovitis." 05/01/2011 - "In accordance with the diagnosis of M kansasii tenosynovitis and the results of antibiotic susceptibility testing, triple therapy with rifampicin, isoniazid and clarithromycin was initiated. "
8.	Uric Acid (Urate)IBA 11/01/2011 - "Routine uric acid determination could be helpful in the preoperative evaluation of patients with flexor tenosynovitis." 11/01/2015 - "Serum uric acid (SUA) was positively correlated with capsular thickening, BME, STE, and tenosynovitis. " 11/01/2015 - "Positive correlations were observed between serum uric acid levels and the following MRI findings: capsular thickening (r = 0.552, p = 0.003), BME (r = 0.668, p ≤ 0.0001), STE (r = 0.559, p = 0.002), and tenosynovitis (r = 0.513, p = 0.006). " 10/01/2015 - "Clinical manifestations of hyperuricemia are acute inflammatory arthritis, tenosynovitis, bursitis, chronic arthropathy and accumulation of urate crystals in the form of tophaceous deposits. "
9.	Antirheumatic Agents (DMARD)IBA 06/01/2000 - "We describe a case in which a previously healthy patient developed bilaterally symmetric synovitis and was treated with disease modifying anti rheumatic drugs (DMARDs); the synovitis progressed into a bilaterally symmetric chronic granulomatous tenosynovitis that was uncontrollable despite a synovectomy and DMARD therapy. " 06/01/2010 - "Addition of etanercept significantly reduced MRI tenosynovitis of the wrist and fingers in patients with active RA refractory to DMARD treatment. " 06/01/2010 - "To assess the efficacy of etanercept in reducing tenosynovitis evaluated by MRI of the hand (h-MRI) in patients with active rheumatoid arthritis (RA) refractory to disease-modifying antirheumatic drug (DMARD) after 6 weeks of treatment. "
10.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 10/01/2002 - "A 61-year-old man with rheumatoid arthritis being treated with only etanercept (soluble tumor necrosis factor receptor) and in remission from the rheumatoid arthritis presented with dorsal tenosynovitis of his right wrist. "

Therapies and Procedures

1.	Injections 12/01/2014 - "We conclude that two or three local steroid injections in the first dorsal compartment lead to significant improvement in patients with de Quervain's tenosynovitis." 01/01/2009 - "The efficacy of corticosteroid injections for de Quervain's tenosynovitis has been studied in only one small controlled clinical trial, which found steroid injections to be superior to thumb spica splinting. " 12/01/2007 - "Are steroid injections effective for tenosynovitis of the hand?" 01/01/2012 - "A recent study from our laboratory has demonstrated improved range of motion in the toes of broiler chickens afflicted with pyogenic flexor tenosynovitis when treated with local antibiotic and corticosteroid injections, without surgical drainage. " 01/01/2009 - "One or two local injections of 1 ml triamcinolonacetonide 10 mg/ml provided by general practitioners leads to improvement in the short term in participants with de Quervain's tenosynovitis when compared to placebo. "
2.	Catheters 01/01/2015 - "The hypothesis of this prospective randomised trial is that intraoperative catheter irrigation alone is as effective as a combination of intraoperative and postoperative intermittent catheter irrigation in the treatment of purulent flexor tenosynovitis. " 10/01/2002 - "Closed-catheter irrigation is as effective as open drainage for treatment of pyogenic flexor tenosynovitis." 03/01/2014 - "An aid to flexor sheath cannulation for closed catheter irrigation of pyogenic flexor tenosynovitis." 06/01/2000 - "Continuous postoperative catheter irrigation is not necessary for the treatment of suppurative flexor tenosynovitis." 12/01/1991 - "A retrospective review of 27 patients (28 fingers) with pyogenic flexor tenosynovitis, who were treated by a limited, open-tendon-sheath, intermittent-irrigation method that utilized a small pediatric feeding catheter, was conducted. "
3.	Debridement 01/01/2015 - "The management of purulent flexor tenosynovitis of the hand consists of surgical debridement followed by antibiotic treatment. " 02/01/2003 - "Tibialis anterior tenosynovitis: Avoiding extensor retinaculum damage during endoscopic debridement." 01/01/2012 - "A diagnosis of flexor tenosynovitis was made and the patient required multiple debridements in theatre, resulting in the amputation of the infected finger. " 02/01/2010 - "Carpal canal syndrome secondary to traumatic suppurative tenosynovitis was treated by accessory carpal bone debridement and carpal retinaculum release using a tenoscopic approach to the carpal flexor synovial sheath through a proximolateral endoscope portal and a distolateral instrument portal. " 08/01/2001 - "Results suggest that horses with osteomyelitis of the ST, with or without concomitant tarsal sheath tenosynovitis, can have an excellent to good outcome and may return to their previous use after surgical debridement of affected tissues and lavage of the tarsal sheath."
4.	Tenodesis 12/01/2003 - "This report describes two dogs with bilateral bicipital tenosynovitis which were managed using double tenodesis. " 12/01/2003 - "Treatment of bicipital tenosynovitis with double tenodesis." 05/01/1983 - "This procedure can be performed at the same time as correction of the primary cause of proximal interphalangeal joint (PIP) hyperextension (e.g., intrinsic tightness or flexor tenosynovitis) and can also be supplemented with superficialis tenodesis to minimize recurrent hyperextension. " 03/01/1982 - "The operation decompresses the acromial arch and also eliminates the biceps tenosynovitis by tenodesis. " 01/01/2011 - "The purpose of this study to compare clinical and isokinetic results of patients who underwent biceps tenotomy or tenodesis for chronic tenosynovitis. "
5.	Braces 09/05/1981 - "In a study to assess the effects of the Futuro wrist brace (Adcock-Ingram) in 22 patients with osteoarthritis, rheumatoid arthritis, tenosynovitis and gout of the wrist, grip and pinch dynamometers were used to measure improvement in function. "