Tannins (Tannic Acid)

Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.

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Networked: 383 relevant articles (19 outcomes, 63 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Soyocak, Ahu: 4 articles (01/2015 - 02/2009)
2.	Sultana, Sarwat: 4 articles (01/2015 - 01/2006)
3.	Hachiro, Yoshikazu: 4 articles (05/2014 - 11/2007)
4.	Abe, Tatsuya: 4 articles (05/2014 - 11/2007)
5.	Kunimoto, Masao: 4 articles (05/2014 - 11/2007)
6.	Wang, Zhao: 4 articles (10/2006 - 06/2003)
7.	Burg, Karen J L: 3 articles (03/2015 - 01/2012)
8.	Ebisawa, Yoshiaki: 3 articles (05/2014 - 11/2007)
9.	Degirmenci, Irfan: 3 articles (04/2011 - 02/2009)
10.	Basaran, Ayse: 3 articles (04/2011 - 02/2009)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1989 - "Tumor induction studies in forestomach and lung revealed significant protection against BP-induced tumorigenesis in animals fed tannic acid-supplemented diet as compared to animals fed control diet. " 12/01/2003 - "Animal studies have demonstrated that a dietary polyphenol known as tannic acid (TA) exhibits anticarcinogenic activity in chemically induced cancers. " 08/01/2003 - "The aim of this study was to assess the anti-CXCL12/CXCR4 activity of a commercial tannic acid and evaluate its potential to inhibit tumor cell migration and angiogenesis in vitro. " 06/01/2003 - "[Review in the studies on tannins activity of cancer prevention and anticancer]." 10/01/2001 - "Animal studies have demonstrated that a dietary polyphenol known as tannic acid (TA) exhibits anticarcinogenic activity in chemically induced cancers, although the involved molecular target remains unknown. "
2.	Infection 12/01/2009 - "Field evidences have suggested that a natural extract, containing tannins, could be effective against poultry enteric viral infections. " 01/01/2014 - "The present study reports the effect of Emblica officinalis (EO) derived tannins on humoral immune responses and their protective efficacy against Eimeria infection in chickens. " 01/01/2014 - "Protective efficacy of tannins was measured against coccidial infection, induced by Eimeria species. " 10/01/2009 - "In this study, we determined whether sheep with a gastrointestinal parasite infection increased intake of a low-quality food containing a natural antiparasitic agent (tannins) relative to non-parasitized sheep. " 07/29/2003 - "The study indicates that the difference in the effects of the two forages on HC infections may be related to type and concentration of tannins."
3.	Pain (Aches) 11/01/2012 - "To assess the efficacy of thrice daily topical 4Jointz utilizing Acteev technology (a combination of a standardized comfrey extract and a pharmaceutical grade tannic acid, 3.5 g/day) on osteoarthritic knee pain, markers of inflammation and cartilage breakdown over 12 weeks. " 09/01/2011 - "The purpose of this study was to determine the effect of 2 concentrations of topical, comfrey-based botanical creams containing a blend of tannic acid and eucalyptus to a eucalyptus reference cream on pain, stiffness, and physical functioning in those with primary osteoarthritis of the knee. " 10/05/2015 - "Furthermore, tannic acid greatly reduced bradykinin-induced pain behavior of rats. " 10/05/2015 - "The bradykinin-induced rat pain model was used to assess the analgesic effect of tannic acid. " 10/05/2015 - "Tannic acid could be a useful agent in treatment of inflammatory pain conditions such as osteoarthritis, rheumatic arthritis and burn pain. "
4.	Body Weight (Weight, Body) 04/01/2015 - "Feed utilisation was improved in all experimental groups and tannic acid also improved final body weight. " 01/15/2011 - "The inclusion of tannins in diets has been shown to improve body weight and wool growth, milk yields and reproductive performance. " 06/01/2008 - "Histopathological examination of the sections showed, major tissue damage with the highest concentration of tannins (1500mg/kg body weight) irrespective of their nature and source, followed by moderate damage with the 1000mg/kgbw and zero damage with 500mg/kgbw. " 03/01/2008 - "Male Wistar rats were treated intraperitoneally with protocatechuic or tannic acid at 50 mg/kg body weight five times during 14 days. " 02/01/1995 - "Dose rates of 1.0 and 2.0 g tannic acid/kg body weight produced abomasal, liver and kidney lesions. "
5.	Poisoning 04/01/1993 - "Protective effects of tannic acid and related natural compounds on Crotalus adamenteus subcutaneous poisoning in mice." 10/01/1960 - "[Histochemical and biochemical studies in acute tannic acid poisoning]." 10/01/1990 - "Although plants containing hydrolysable tannins can be hepatotoxic, such poisoning has not been reported in Indonesia despite the presence of these plants. " 10/01/1988 - "Diagnosis of oak poisoning was made based on the renal lesions and the finding of a high content of tannins in the liver and gastrointestinal tract. " 01/01/1987 - "Four tannins were isolated from dried leaves of Thiloa glaucocarpa, which is one of the plants causing poisoning of cattle in Brazil. "

Related Drugs and Biologics

1.	Tannins (Tannic Acid)
2.	resveratrol
3.	Antibodies
4.	Quercetin
5.	aluminum sulfate (alum)
6.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
7.	Phytic Acid (Inositol Hexaphosphate)
8.	Oligosaccharides
9.	Raffinose
10.	Nitric Oxide Synthase (NO Synthase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation (Transplant Recipients)
3.	Sclerotherapy
4.	Chemoprevention
5.	Enema (Enemas)