Talc

Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)

Also Known As:

Networked: 926 relevant articles (63 outcomes, 116 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Light, R W: 11 articles (08/2003 - 01/2000)
2.	Vargas, Francisco S: 9 articles (11/2009 - 12/2002)
3.	Marchi, Evaldo: 9 articles (11/2009 - 12/2002)
4.	Lee, Y C Gary: 8 articles (01/2014 - 12/2003)
5.	Cramer, Daniel W: 7 articles (03/2014 - 05/2005)
6.	Light, Richard W: 7 articles (07/2012 - 01/2002)
7.	Antonangelo, Leila: 7 articles (11/2009 - 12/2002)
8.	Teixeira, Lisete R: 7 articles (11/2009 - 12/2002)
9.	Davies, Robert J O: 6 articles (06/2012 - 12/2003)
10.	Vargas, F S: 6 articles (02/2010 - 09/2000)

Related Diseases

1.	Malignant Pleural Effusion 12/01/2006 - "Our study confirms that intrapleural talc carries good results in the treatment of malignant pleural effusion. " 01/01/2013 - "While talc is now accepted to be a worldwide gold-standard sclerosing agent for treating malignant pleural effusion, it is not yet approved in Japan. " 04/01/2007 - "The present study evaluated the angiogenic balance in the pleural space in patients with malignant pleural effusions (MPE) following talc insufflation. " 12/01/1996 - "We designed a prospective, randomized study to compare video-assisted thoracoscopic talc insufflation with bedside talc slurry in the treatment of malignant pleural effusion. " 12/01/2014 - "This case series summarizes the safety and efficacy data of all patients (24) with a symptomatic malignant pleural effusion who underwent talc pleurodeses via IPCs between December 2010 and July 2013. "
2.	Pneumothorax 10/01/1994 - "We conclude from these observations that the insufflation of 2 g of talc into the pleural space is a safe effective treatment for control of recurrent spontaneous pneumothorax." 11/01/2004 - "Feasibility, safety and efficacy of VATS for management of recurrent primary spontaneous pneumothorax following thoracoscopic talc poudrage are strongly suggested." 07/01/2012 - "The aim of this study was to compare talc poudrage and pleural abrasion in the treatment of spontaneous pneumothorax. " 07/01/2012 - "Comparative study of talc poudrage versus pleural abrasion for the treatment of primary spontaneous pneumothorax." 10/01/2011 - "A complete response was obtained in all patients with pneumothorax in both the iodopovidone and talc groups. "
3.	Pleural Effusion (Pleural Effusions) 07/01/1995 - "Recent study results indicate that intrapleural instillation of iodized talc is an adequate and effective treatment for control of neoplastic or benign pleural effusion." 06/01/1995 - "The intrapleural insufflation of talc was effective in preventing recurrence of pleural effusion. " 05/01/1992 - "These observations indicate that intrapleural instillation of a slurry of iodized talc is a safe, adequate, and effective treatment for control of neoplastic or benign pleural effusions." 12/01/2011 - "Not more effective than talc in preventing recurrent pleural effusions, based on a review with meta-analysis of 7 trials in 256 patients. " 12/01/1994 - "The objective of this study is to present our experience with a low dose of aerosolized talc for controlling nonmalignant pleural effusions. "
4.	Hydrothorax 07/01/2000 - "Thoracoscopy and talc poudrage in the management of hepatic hydrothorax." 11/01/1996 - "Video-assisted thoracic surgery with talc poudrage is an effective and safe procedure with minimal morbidity for management of hydrothorax secondary to CAPD. " 08/01/2006 - "Efficacy of video-assisted thoracoscopic surgery with talc pleurodesis for porous diaphragm syndrome in patients with refractory hepatic hydrothorax." 09/01/2004 - "Talc pleurodesis can be offered to patients with hepatic hydrothorax. " 05/01/2004 - "Three patients whose hydrothorax was refractory to medical treatment were treated by pleurodesis with talc. "
5.	Dyspnea (Shortness of Breath) 06/13/2012 - "There was a statistically significant improvement in dyspnea in the IPC group at 6 months, with a mean difference in VAS score between the IPC group and the talc group of −14.0 mm (95% CI, −25.2 to −2.8 mm; P = .01). " 06/13/2012 - "Dyspnea improved in both groups, with no significant difference in the first 42 days with a mean VAS dyspnea score of 24.7 in the IPC group (95% CI, 19.3-30.1 mm) and 24.4 mm (95% CI, 19.4-29.4 mm) in the talc group, with a difference of 0.16 mm (95% CI, −6.82 to 7.15; P = .96). " 10/01/1995 - "Although her shortness of breath was relieved following VAT decortication and talc insufflation, at 3 months she was found to have a 2.5-cm subcutaneous nodule at the camera port site which on biopsy was confirmed to be metastatic in nature. " 01/01/2010 - "Video-assisted thoracoscopic talc poudrage is an effective and safe procedure that yields a high rate of successful pleurodesis and achieves long-term control with marked dyspnea decrease." 06/01/2001 - "The VATS talc pleurodesis resulted in clinically significant improvement of dyspnea in 92.2% of the patients. "

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Doxycycline (Vibramycin)
3.	Povidone-Iodine (Betadine)
4.	Minocycline (Cyclops)
5.	pemetrexed (MTA)
6.	Thymidine Monophosphate (TMP)
7.	raltitrexed (D 1694)
8.	Opioid Analgesics (Opioids)
9.	Staphylococcal Protein A (A, Protein)
10.	Tetracycline (Achromycin)

Related Therapies and Procedures

1.	Pleurodesis
2.	Catheters
3.	Chest Tubes (Chest Tube)
4.	Thoracostomy
5.	Palliative Care (Palliative Medicine)