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Takayasu Arteritis (Arteritis, Takayasu's)

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A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.

Also Known As:

Arteritis, Takayasu's; Takayasu Disease; Takayasu Syndrome; Takayasu's Arteritis; Young Female Arteritis; Arteritides, Young Female; Arteritis, Takayasu; Arteritis, Takayasus; Arteritis, Young Female; Disease, Takayasu; Female Arteritides, Young; Female Arteritis, Young; Syndrome, Aortitis; Takayasus Arteritis; Young Female Arteritides; Aortitis Syndrome; Pulseless Disease

Networked: 872 relevant articles (40 outcomes, 50 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Giant Cell Arteritis (Horton Disease)
2.	Vasculitis (Vasculitides)
3.	Aortitis
4.	Aneurysm (Aneurysms)
5.	Pulmonary Valve Stenosis (Pulmonary Stenosis)

Experts

1.	Direskeneli, Haner: 11 articles (09/2015 - 09/2010)
2.	Hoffman, Gary S: 9 articles (07/2015 - 06/2002)
3.	Mason, Justin C: 7 articles (12/2015 - 05/2004)
4.	Merkel, Peter A: 7 articles (05/2015 - 07/2004)
5.	Mahajan, Nitin: 7 articles (01/2014 - 09/2006)
6.	Dhawan, Veena: 7 articles (01/2014 - 09/2006)
7.	Jain, Sanjay: 7 articles (09/2013 - 09/2005)
8.	Nityanand, Soniya: 7 articles (09/2008 - 08/2003)
9.	Kawakami, Atsushi: 6 articles (12/2015 - 01/2006)
10.	Alibaz-Oner, Fatma: 6 articles (09/2015 - 05/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Takayasu Arteritis:

1.	Methotrexate (Mexate)FDA LinkGeneric 10/01/1989 - "This is the first case report of Takayasu's arteritis treated successfully with low-dose pulse methotrexate." 01/01/1994 - "At present, methotrexate appears to be an effective steroid-sparing agent in the treatment of active Takayasu's arteritis. " 11/01/2007 - "The two patients who stopped methotrexate treatment died from complications of Takayasu's arteritis. " 05/01/1998 - "Low-dose methotrexate as a steroid-sparing agent in a child with Takayasu's arteritis." 04/01/1994 - "Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate."
2.	tocilizumab FDA Link 05/01/2014 - "Takayasu arteritis and NYHA III/IV idiopathic cardiomiopathy: tocilizumab proves effective and safe." 12/01/2013 - "The aim of our study was to evaluate the safety and the efficacy of tocilizumab (TCZ) for refractory Takayasu arteritis (TA). " 10/01/2013 - "The aim of this study is to analyze the efficacy and tolerance of tocilizumab in patients with Takayasu arteritis (TA). " 01/01/2015 - "Cytokine storm after cessation of tocilizumab in a patient with refractory Takayasu arteritis." 12/01/2013 - "To assess outcome of 10 'difficult to treat' patients with Takayasu arteritis (TA) treated with tocilizumab. "
3.	infliximab (Remicade)FDA Link 06/01/2007 - "Infliximab might be an effective and safe alternative for patients with Takayasu arteritis." 12/01/2012 - "Long-term efficacy of infliximab for treating Takayasu arteritis." 01/01/2009 - "Here we report the case of a patient affected by Takayasu arteritis unresponsive to conventional therapy who was then treated with infliximab and obtained a clinical remission of the disease." 05/01/2012 - "Efficacy and tolerance of infliximab in refractory Takayasu arteritis: French multicentre study." 11/01/2013 - "Outcomes of patients with takayasu arteritis treated with infliximab."
4.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 07/01/2011 - "The aim of the study was to assess vessel involvement and activity of Takayasu arteritis (TA) with whole-body magnetic resonance angiography (MRA) and vessel wall imaging. " 05/01/2013 - "We report the novel case of a young woman with Takayasu arteritis, with extensive large vessel disease. " 05/01/2013 - "Large vessel calcification in Takayasu arteritis." 01/01/2013 - "Small vessel involvement in Takayasu's arteritis." 05/01/2012 - "We describe the management of a case of Takayasu's arteritis who presented with recurrent vertebro-basilar symptoms and a single surviving arch vessel. "
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/01/2013 - "The objective of this study was to report the long-term use of tumor necrosis factor (TNF) inhibitors in case series of patients with Takayasu's arteritis refractory to standard immunosuppressive treatment. " 05/01/2010 - "The aim of this study was to describe clinical features and response to different therapeutic interventions, including anti-tumor necrosis factor (TNF) agents, in a case series of Takayasu arteritis (TA) from Brazil. " 09/01/2008 - "Anti-tumor necrosis factor agents can have a role in the treatment of Takayasu's arteritis; further controlled studies are required." 07/01/2014 - "To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA). " 12/01/2013 - "Tumor necrosis factor alpha inhibitors in patients with Takayasu's arteritis refractory to standard immunosuppressive treatment: cases series and review of the literature."
6.	Prednisone (Sone)FDA LinkGeneric 01/01/2012 - "Based on the clinical examination and studies, the diagnosis was Takayasu's arteritis, type I. The patient's condition stabilized after 2 months of prednisone and anti-platelet therapy. " 08/04/2006 - "TREATMENT AND FOLLOW-UP: The diagnosis of Takayasu's arteritis was made, and high-dose prednisone treatment was initiated. " 05/01/1998 - "We report a 4-year-old child with Takayasu's arteritis who was initially placed on oral prednisone (2 mg/kg/day) therapy. " 07/01/1992 - "A 42 year old woman with Takayasu's arteritis responded to treatment with prednisone (60 mg daily) but developed severe side effects. " 01/01/2011 - "Medical therapy improved Thrombolysis in Myocardial Infarction flow in the area of the giant aneurysm from grade 1 to grade 3. Upon the diagnosis of Takayasu arteritis, intravenous methylprednisolone and oral prednisone therapy was started. "
7.	mycophenolate mofetil (Cellcept)FDA LinkGeneric 03/01/2010 - "Mycophenolate mofetil in Takayasu's arteritis." 11/01/2007 - "Mycophenolate mofetil reduces disease activity and steroid dosage in Takayasu arteritis." 03/02/1999 - "To evaluate the effect of mycophenolate mofetil in patients with severe Takayasu arteritis. " 03/02/1999 - "Mycophenolate mofetil for the treatment of Takayasu arteritis: report of three cases." 11/01/2007 - "Mycophenolate mofetil (MMF) has recently been reported as a useful alternative immunosuppressive drug in autoimmune diseases including in Takayasu arteritis (TA). "
8.	adalimumab (Humira)FDA Link 12/01/2015 - "Adalimumab-induced remission of anterior scleritis: a very rare late manifestation of Takayasu arteritis." 09/01/2005 - "Refractory Takayasu's arteritis successfully treated with the human, monoclonal anti-tumor necrosis factor antibody adalimumab." 11/01/2014 - "Patients completed therapeutic scheme with chemotherapy (doxorubicin and isosfamide) and radiotherapy for the cancer condition, as well as medical treatment (prednisone and adalimumab) for Takayasu arteritis. " 03/01/2013 - "Here, however, we describe the case of two patients: one with seropositive rheumatoid arthritis, the other with HLA-B27 negative spondylarthropathy, who developed Takayasu's arteritis during treatment with TNFa inhibitors (adalimumab and golimumab respectively). " 01/01/2012 - "A 28-year-old patient with Takayasu's arteritis (TA) failed to respond to high doses of prednisone in combination with methotrexate, pulses of cyclophosphamide and methylprednisolone, azathioprine, mycophenolate mofetil, adalimumab and monthly infusions of infliximab 5 mg/kg. After the beginning of tocilizumab therapy (4-8 mg/kg at monthly infusions), an impressive improvement in clinical and laboratory parameters of disease activity occurred, allowing the reduction of prednisone dose from 30 to 5 mg/day. "
9.	Azathioprine (Imuran)FDA LinkGeneric 08/01/2003 - "To evaluate the role of an immunosuppressive regimen consisting of azathioprine and prednisolone on the clinical, immunological, and angiographic outcome in patients with active Takayasu's arteritis (TA). " 06/01/2007 - "We used infliximab at an initial dose of 3 mg/kg i.v. at weeks 0, 2, 6, and 8 thereafter in combination with methotrexate or azathioprine, to treat four patients with Takayasu arteritis. " 01/01/2005 - "Immunosuppressive agents including methotrexate, mycophenolate mofetil, and azathioprine added to corticosteroids can bring Takayasu arteritis into remission in many patients. " 01/01/2012 - "A 28-year-old patient with Takayasu's arteritis (TA) failed to respond to high doses of prednisone in combination with methotrexate, pulses of cyclophosphamide and methylprednisolone, azathioprine, mycophenolate mofetil, adalimumab and monthly infusions of infliximab 5 mg/kg. After the beginning of tocilizumab therapy (4-8 mg/kg at monthly infusions), an impressive improvement in clinical and laboratory parameters of disease activity occurred, allowing the reduction of prednisone dose from 30 to 5 mg/day. "
10.	Methylprednisolone FDA LinkGeneric 01/01/2011 - "Medical therapy improved Thrombolysis in Myocardial Infarction flow in the area of the giant aneurysm from grade 1 to grade 3. Upon the diagnosis of Takayasu arteritis, intravenous methylprednisolone and oral prednisone therapy was started. " 01/01/2006 - "Takayasu arteritis had developed in a 24-year-old woman (March 2003) who had been treated with glucocorticoid including methylprednisolone pulse therapy and methotrexate; however, she relapsed during the tapering of the dosage of oral prednisolone. " 01/01/2012 - "A 28-year-old patient with Takayasu's arteritis (TA) failed to respond to high doses of prednisone in combination with methotrexate, pulses of cyclophosphamide and methylprednisolone, azathioprine, mycophenolate mofetil, adalimumab and monthly infusions of infliximab 5 mg/kg. After the beginning of tocilizumab therapy (4-8 mg/kg at monthly infusions), an impressive improvement in clinical and laboratory parameters of disease activity occurred, allowing the reduction of prednisone dose from 30 to 5 mg/day. "

Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal) 05/01/2009 - "Interim outcome of endovascular management of Takayasu arteritis (TA) was determined retrospectively to assess the efficacy of angioplasty and/or stenting in 24 patients with 35 lesions in the chronic inactive stage. " 12/01/2014 - "Corkscrew intravascular channels within chronic common carotid artery occlusions in takayasu arteritis that disappear after angioplasty." 09/01/2013 - "Coronary angioplasty of left main coronary artery in patient with Takayasu's arteritis." 07/01/2013 - "[Angioplasty of the vertebral artery in Takayasu's arteritis]." 02/14/2012 - "With recent advances in endovascular treatment, percutaneous endoluminal angioplasty has become particularly attractive for arterial lesions of Takayasu arteritis. "
2.	Stents 03/01/2004 - "We suggest that surgical treatment is beneficial for in-stent restenosis in patient with Takayasu arteritis." 12/01/2000 - "Our series demonstrates the safety and efficacy of stent deployment in stenotic lesions of the aorta in Takayasu arteritis and proves that the results are superior to plain balloon aortoplasty alone. " 04/01/2015 - "We report a patient with Takayasu disease who presented with a very difficult clinical course associated with several unfavourable outcomes of stent insertion. " 01/01/2012 - "Recurrent coronary in-stent restenosis in Takayasu's arteritis." 04/01/2010 - "Pregnancy in Takayasu's arteritis with bilateral renal artery and abdominal aorta stents."
3.	Balloon Angioplasty 01/01/2011 - "Many studies have reported that the management of stenotic lesions of the LMCA with endoluminal stenting and balloon angioplasty and de-novo stenting is safe and effective for patients with Takayasu's arteritis. " 02/01/2009 - "[Percutaneous transluminal abdominal artery cutting balloon angioplasty treatment in two children with Takayasu's arteritis]." 08/31/2000 - "A follow-up study of balloon angioplasty and de-novo stenting in Takayasu arteritis." 10/01/1992 - "Balloon angioplasty of the aorta in Takayasu's arteritis: initial and long-term results." 01/01/1992 - "Percutaneous transluminal balloon angioplasty (PTBA) was performed in 87 patients for 111 stenotic lesions due to Takayasu arteritis. "
4.	Transplantation (Transplant Recipients) 03/01/2014 - "Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome." 01/01/1994 - "Renal autograft transplantation has been offered as a new technique in the management of hypertension in Takayasu's arteritis." 07/01/1992 - "Management of renal hypertension in children with Takayasu's arteritis using renal autografting or allograft transplantation in selected circumstances and total lymphoid irradiation."
5.	Immunotherapy 01/01/2015 - "The outlook in Takayasu arteritis has improved over the last decade, reflecting earlier diagnosis, increased use of noninvasive imaging and combination immunotherapy. " 02/01/2012 - "We described the effect of peptide-loaded DCs-based immunotherapy on patient with recurrent surgically resected adenocarcinoma with bronchoalveolar feature with co-existing of Takayasu arteritis and chronic hepatitis B. "