Takayasu Arteritis (Arteritis, Takayasu's)

A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.

Also Known As:

Arteritis, Takayasu's; Takayasu Disease; Takayasu Syndrome; Takayasu's Arteritis; Young Female Arteritis; Arteritides, Young Female; Arteritis, Takayasu; Arteritis, Takayasus; Arteritis, Young Female; Disease, Takayasu; Female Arteritides, Young; Female Arteritis, Young; Syndrome, Aortitis; Takayasus Arteritis; Young Female Arteritides; Aortitis Syndrome; Pulseless Disease

Networked: 1273 relevant articles (91 outcomes, 116 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Giant Cell Arteritis (Horton Disease)
2.	Vasculitis (Vasculitides)
3.	Ulcerative Colitis
4.	Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
5.	Inflammation (Inflammations)

Experts

1.	Jiang, Lindi: 23 articles (01/2022 - 04/2012)
2.	Ma, Lili: 21 articles (01/2022 - 04/2012)
3.	Danda, Debashish: 18 articles (01/2022 - 03/2010)
4.	Kong, Xiufang: 18 articles (01/2022 - 05/2016)
5.	Sun, Ying: 18 articles (01/2022 - 04/2012)
6.	Goel, Ruchika: 16 articles (01/2022 - 03/2010)
7.	Isobe, Mitsuaki: 16 articles (01/2021 - 05/2006)
8.	Baldissera, Elena: 12 articles (11/2022 - 10/2011)
9.	Salvarani, Carlo: 12 articles (11/2022 - 10/2011)
10.	Kawakami, Atsushi: 12 articles (04/2022 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Takayasu Arteritis:

1.	tocilizumab (atlizumab)FDA Link 01/01/2023 - "The IL-6R antibody tocilizumab has been proven effective in treating Takayasu arteritis (TA). " 01/01/2023 - "Tocilizumab is proved to be a rapid remission inducing agent in refractory Takayasu arteritis in observational studies. " 05/01/2014 - "Takayasu arteritis and NYHA III/IV idiopathic cardiomiopathy: tocilizumab proves effective and safe." 03/02/2023 - "The efficacy of tocilizumab (TCZ) in the treatment of Takayasu arteritis (TA) was demonstrated in randomized controlled trials. " 12/01/2013 - "The aim of our study was to evaluate the safety and the efficacy of tocilizumab (TCZ) for refractory Takayasu arteritis (TA). "
2.	SteroidsIBA 08/01/2022 - "A diagnosis of Takayasu arteritis (TA) was made, and the patient was treated with high-dose steroids with significant improvement in her symptoms." 01/10/2017 - "To the authors knowledge, there are no publications using biological agents in combination with steroids as a first-line treatment in Takayasu arteritis. " 10/01/2022 - "She was diagnosed with Takayasu's arteritis and was prescribed steroids, on which she gradually recovered and was discharged. " 03/01/2021 - "She was diagnosed with Takayasu's arteritis ~ 30 years ago and was treated with oral steroids daily. " 02/01/1995 - "For healed phase aortitis syndrome perioperative steroid administration was not necessary. "
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/01/2010 - "The aim of this study was to describe clinical features and response to different therapeutic interventions, including anti-tumor necrosis factor (TNF) agents, in a case series of Takayasu arteritis (TA) from Brazil. " 09/01/2008 - "Anti-tumor necrosis factor agents can have a role in the treatment of Takayasu's arteritis; further controlled studies are required." 11/01/2020 - "Elevated tumor necrosis factor-α (TNF-α) is correlated with refractory Takayasu arteritis (TA), and resistance exercise have been shown to inhibit TNF-α. " 12/01/2013 - "Tumor necrosis factor alpha inhibitors in patients with Takayasu's arteritis refractory to standard immunosuppressive treatment: cases series and review of the literature." 03/01/2013 - "Compelling evidence exists to support the notion that Takayasu's arteritis is a T-cell mediated process and that tumor necrosis factor alpha (TNFa) is an important factor in the pathogenesis of this disease. "
4.	Methotrexate (Mexate)FDA LinkGeneric 10/01/1989 - "This is the first case report of Takayasu's arteritis treated successfully with low-dose pulse methotrexate." 12/21/2022 - "Clinical and angiographic outcomes of Mycophenolate versus Methotrexate in South Asian patients of Takayasu arteritis: Results from an open-label, randomised controlled trial." 11/01/2007 - "The two patients who stopped methotrexate treatment died from complications of Takayasu's arteritis. " 10/01/1989 - "Multiple percutaneous transluminal angioplasties and low dose pulse methotrexate for Takayasu's arteritis." 07/01/1992 - "Induction of remission in a patient with Takayasu's arteritis by low dose pulses of methotrexate."
5.	Infliximab (Remicade)FDA Link 06/01/2007 - "Infliximab might be an effective and safe alternative for patients with Takayasu arteritis." 12/02/2020 - "Objective: To analyze the clinical characteristics of infantile Takayasu arteritis and the efficacy of infliximab (IFX). " 12/01/2012 - "Long-term efficacy of infliximab for treating Takayasu arteritis." 05/01/2012 - "Efficacy and tolerance of infliximab in refractory Takayasu arteritis: French multicentre study." 08/04/2022 - "There is insufficient evidence on the clinical effectiveness and safety of infliximab (IFX) treatment of Takayasu arteritis (TA) in infants. "
6.	GlucocorticoidsIBA 07/01/2018 - "Non-glucocorticoid drugs for the treatment of Takayasu's arteritis: A systematic review and meta-analysis." 01/01/2018 - "A diagnosis of Takayasu arteritis was made and patient was started on high dose glucocorticoids. " 01/01/2017 - "We aimed to investigate the effects of immunosuppressive and biological agents on refractory Takayasu arteritis (TA) patients resistant to or dependent on glucocorticoids. " 01/01/2017 - "Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment." 11/01/2017 - "High-dose glucocorticoid therapy and immunosuppressive therapy have been used to control inflammatory reaction during acute period of Takayasu arteritis. "
7.	Tumor Necrosis Factor InhibitorsIBA 12/01/2013 - "TNF inhibitors were highly effective and safe in patients with refractory Takayasu's arteritis." 01/01/2021 - "Takayasu's arteritis occurring under TNF blockers in a patient with spondyloarthritis: is it an association or a paradoxical effect?" 12/01/2013 - "Nine women (median age of 29 years) with refractory Takayasu's arteritis were treated with TNF inhibitors. " 07/01/2012 - "Tumor necrosis factor inhibitors in patients with Takayasu arteritis: experience from a referral center with long-term followup." 09/01/2008 - "Treatment of Takayasu's arteritis with tumor necrosis factor antagonists."
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/2021 - "Objective: Although biologic agents are used in Takayasu arteritis (TAK), corticosteroids are still the mainstay of treatment. " 10/01/2021 - "We evaluated clinical response, normalization of inflammatory markers, angiographic stabilization (primary outcomes), relapses and adverse events (secondary outcomes) in Takayasu arteritis (TAK) patients following corticosteroid monotherapy. " 10/01/2021 - "Corticosteroid monotherapy for the management of Takayasu arteritis-a systematic review and meta-analysis." 01/01/2021 - "The pathogenesis of Takayasu arteritis involves immune-mediated mechanisms, and corticosteroids represent the mainstay for treatment. " 04/01/2019 - "To analyze the clinical outcome of corticosteroid and/or immunosuppressive treatment preoperatively in patients with Takayasu's arteritis. "
9.	Mycophenolic Acid (Cellcept)FDA LinkGeneric 07/01/2017 - "The efficacy of mycophenolate mofetil in treating Takayasu arteritis: a systematic review and meta-analysis." 12/07/2016 - "The efficacy of Mycophenolate mofetil for the treatment of Chinese Takayasu's arteritis." 07/01/2017 - "The purpose of this study is to assess the effectiveness of mycophenolate mofetil (MMF) in treating Takayasu arteritis (TA) patients. " 03/01/2010 - "Mycophenolate mofetil in Takayasu's arteritis." 03/02/1999 - "To evaluate the effect of mycophenolate mofetil in patients with severe Takayasu arteritis. "
10.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/01/2020 - "Diagnostic Role and Feasibility of 18F-FDG PET for Assessing Takayasu Arteritis: Diagnostic Efficacy of Quantifying 18F-FDG Uptake." 01/01/2018 - "The aim of this study was to quantify the association between the CRP value and 18F-FDG PET vascular positivity in Takayasu arteritis (TAK) through a structured dedicated systematic review and meta-analysis. " 07/01/2023 - "An exploration of the feasibility and clinical value of half-dose 5-h total-body 18F-FDG PET/CT scan in patients with Takayasu arteritis." 04/01/2022 - "Assessment of Takayasu arteritis in routine practice with PETVAS, an 18F-FDG PET quantitative scoring tool." 03/01/2022 - "18F-FDG PET/CT in the diagnosis of Takayasu arteritis: A case report."

Therapies and Procedures

1.	Therapeutics 04/01/1994 - "Further long-term studies will be required to assess the durability of remission and the need for maintenance MTX therapy in this subset of Takayasu arteritis patients." 01/01/1993 - "Neither technique has replaced angiography as the gold standard for diagnosis, but both may help monitor the response of Takayasu's arteritis to therapy. " 04/01/2023 - "There is currently no unanimous consensus on the treatment of Takayasu's arteritis (TAK) involving the pulmonary artery, and there are very few related studies that compare the efficacies of drug-based therapy and revascularization. " 03/01/2013 - "Moreover, encouraging results from recent studies support the use of anti-TNFa therapy for relapsing or resistant cases of Takayasu's arteritis. " 07/01/2023 - "We describe ophthalmic manifestations, therapy, and outcomes in 16 patients with Takayasu arteritis (TA). "
2.	Stents 11/01/2009 - "Percutaneous transluminal angioplasty and stent implantation for stenotic lesions of renal arteries and other branches of the aorta in Takayasu's arteritis have been reported to show good outcomes. " 03/01/2004 - "We suggest that surgical treatment is beneficial for in-stent restenosis in patient with Takayasu arteritis." 12/01/2000 - "Our series demonstrates the safety and efficacy of stent deployment in stenotic lesions of the aorta in Takayasu arteritis and proves that the results are superior to plain balloon aortoplasty alone. " 09/01/2023 - "Takayasu arteritis and stent always end in tears." 11/01/2022 - "PURPOSE Despite frequent use of self-expanding stents (SES) in treating obstructive arterial lesions in Takayasu arteritis (TA), spontaneous delayed stent expansion (SDSE) in TA remains unstudied. "
3.	Aftercare (After-Treatment) 03/01/2017 - "Conclusions Our results suggest that mean platelet volume may identify active disease in patients with Takayasu arteritis, and the values of mean platelet volume may help to establish remission of active disease after treatment in Takayasu arteritis patients." 01/01/2022 - "The inflammatory indexes of children with Takayasu arteritis (TAK) usually tend to be normal immediately after treatment, therefore, CT angiography (CTA) has become an important method to evaluate the status of TAK and sometime is even more sensitive than laboratory test results. " 06/01/2018 - "The patient was also found to have Takayasu arteritis and subsequently received outpatient follow-up care. " 01/01/2017 - "Improvement of Arterial Wall Lesions in Parallel with Decrease of Plasma Pentraxin-3 Levels in a Patient with Refractory Takayasu Arteritis after Treatment with Tocilizumab." 01/01/2017 - "Here we present a case report of a young woman with Takayasu arteritis, who presented a palpable mass in the back of her neck, significantly diminished after treatment with glucocorticoids."
4.	Biological Therapy 07/01/2018 - "Recent studies suggested that anti-TNF-α biological therapies are effective in treating Takayasu's arteritis (TA) refractory to conventional immunosuppressive therapy. " 01/01/2020 - "Early use of biologic therapy in those with supra-aortic Takayasu arteritis presenting with cerebral ischaemia may reduce the numbers of patients requiring surgical intervention and improve outcomes." 01/01/2020 - "Biologic therapy in supra-aortic Takayasu arteritis can improve symptoms of cerebral ischaemia without surgical intervention." 01/01/2019 - "Most of patients with diagnosis of both these diseases required biologic therapies than patients with diagnosis of Takayasu arteritis alone (64.3% vs 29.1%, P = 0.014) due to refractory Takayasu arteritis. " 01/01/2014 - "Recent advances in the medical management of Takayasu arteritis: an update on use of biologic therapies."
5.	Transplantation 03/01/2014 - "Significant improvement of Takayasu arteritis after cord blood transplantation in a patient with myelodysplastic syndrome." 01/01/2020 - "We, herein, present on a patient with Takayasu arteritis causing severe renal failure and a successful auto-transplantation. " 01/01/1994 - "Renal autograft transplantation has been offered as a new technique in the management of hypertension in Takayasu's arteritis." 11/01/2020 - "Autologous hematopoietic stem cell transplantation with reduced-intensity conditioning regimens in refractory Takayasu arteritis: a retrospective multicenter case-series from the Autoimmune Diseases Working Party (ADWP) of the European Society for Blood and Marrow Transplantation (EBMT)." 07/01/1992 - "Management of renal hypertension in children with Takayasu's arteritis using renal autografting or allograft transplantation in selected circumstances and total lymphoid irradiation."