Sinus Tachycardia

Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in adults. It is characterized by a gradual onset and termination. Sinus tachycardia is common in infants, young children, and adults during strenuous physical activities.

Also Known As:

Networked: 415 relevant articles (23 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cardiomyopathies (Cardiomyopathy)
2.	Body Weight (Weight, Body)
3.	Atrial Fibrillation
4.	Atrial Flutter (Flutter, Atrial)
5.	Cardiac Arrhythmias (Arrythmia)

Experts

1.	Kem, David C: 5 articles (12/2015 - 03/2013)
2.	Cunningham, Madeleine W: 5 articles (12/2015 - 03/2013)
3.	Scherlag, Benjamin J: 5 articles (12/2015 - 09/2008)
4.	Yu, Xichun: 5 articles (12/2015 - 03/2013)
5.	Li, Hongliang: 5 articles (12/2015 - 03/2013)
6.	Lazzara, Ralph: 4 articles (08/2014 - 09/2008)
7.	Benbrook, Alexandria: 3 articles (06/2015 - 02/2014)
8.	Ptaszynski, Pawel: 3 articles (07/2013 - 01/2013)
9.	Kaczmarek, Krzysztof: 3 articles (07/2013 - 01/2013)
10.	Ruta, Jan: 3 articles (07/2013 - 01/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sinus Tachycardia:

1.	ivabradineIBA 01/01/2009 - "The results of our study show that patients with inappropriate sinus tachycardia can be successfully treated with ivabradine." 10/09/2012 - "In this cohort, ivabradine significantly improved symptoms associated with inappropriate sinus tachycardia and completely eliminated them in approximately half of the patients. " 12/01/2010 - "Ivabradine appears effective and safe in patients with symptomatic inappropriate sinus tachycardia." 10/09/2012 - "Clinical efficacy of ivabradine in patients with inappropriate sinus tachycardia: a prospective, randomized, placebo-controlled, double-blind, crossover evaluation." 09/01/2010 - "Efficacy of ivabradine administration in patients affected by inappropriate sinus tachycardia."
2.	Metoprolol (Lopressor)FDA LinkGeneric 01/01/1998 - "Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol. " 08/01/2012 - "In order to answer the question of how IP metoprolol affects sinus tachycardia, atrial electrophysiology, and pharmacokinetics compared with IV delivery, a medial sternotomy was performed on 21 swine that were divided into three groups: (1) After inducing sinus tachycardia, metoprolol boluses were delivered IP (n = 4) or IV (n = 4); (2) metoprolol was administered either IP (n = 3) or IV (n = 3) with saline controls (n = 3), and electrophysiologic data were collected; (3) metoprolol levels were tracked both in the blood (IV, n = 2) and pericardial (IP, n = 2) fluid. " 10/31/1980 - "The influence of continuous intravenous administration of metoprolol on heart rate and haemodynamics was tested in ten unconscious patients who, after sustaining a head injury, developed sinus tachycardia due to increased sympathicotonia. " 08/01/1980 - "The use of intravenous metoprolol in a dose of 0.06--0.17 mg/kg body weight proved effective in the treatment of sinus tachycardia in excess of 150 beats/min and/or ventricular dysrhythmias associated with light halothane anaesthesia for outpatient dental surgery. " 11/01/1995 - "With regard to perioperative arrhythmias, there was a significantly lower incidence of sinus tachycardia and atrial flutter/fibrillation in the nifedipine-metoprolol group (9% and 6%) than in the nifedipine group (33% and 27%, p < 0.05). "
3.	bipiperidyl mustard (BPM)IBA 02/01/2007 - "An initial electrocardiogram (ECG) revealed a sinus tachycardia with a rate of 110 beats per minute (bpm) and a QRS interval of 93 ms. She was transferred to a pediatric toxicology referral center and had progressive improvement in her symptoms. " 06/24/2010 - "A diagnosis of Inappropriate Sinus Tachycardia was made based on Holter monitoring studies with an average heart rate of 121 beat per minute (bpm). " 04/01/2015 - "Inappropriate sinus tachycardia is characterized by an unexplained increase of the resting sinus rate (> 100 bpm) with excess increase in response to moderate activity (mean heart rate > 90 bpm/24 h). " 10/01/2010 - "In all patients, treatment was begun after verification of basal heart rate greater than 100 bpm and after other causes of sinus tachycardia had been ruled out. " 06/01/2006 - "The resting ECG showed a sinus tachycardia with 110 bpm. "
4.	Propranolol (Inderal)FDA LinkGeneric 09/15/2011 - "At the dose administered, propranolol was effective for short-term control of sinus tachycardia, but it did not alleviate all clinical signs in patients in the present report. " 12/01/2000 - "In five patients in whom sinus tachycardia developed after onset of hemodynamic stable VT, propranolol was more effective than Class III antiarrhythmics combined with another beta-blocking agent with regard to the incidence of VT and pace termination. " 08/01/1997 - "The results were compared with those produced by propranolol, which is used in the treatment of sinus tachycardia. " 12/01/1980 - "She was treated symptomatically and became conscious within 36 hr. However, approximately 65 hr after the overdose she developed sinus tachycardia which was successfully treated with oral propranolol. " 01/01/1978 - "Propranolol in neurosurgical patients with sinus tachycardia. "
5.	esmolol (Brevibloc)FDA LinkGeneric 02/01/1989 - "The study demonstrated no apparent effect of esmolol on blood pressure but that esmolol is effective in treating perioperative sinus tachycardia." 12/01/2000 - "Intrapericardial esmolol suppresses adrenergically induced sinus tachycardia without decreasing contractility or blood pressure. " 07/01/1997 - "Esmolol or other beta-blocker may be indicated to reduce severe sinus tachycardia. " 10/01/1990 - "We evaluated the clinical effectiveness of esmolol, an ultra-short-acting beta 1-adrenergic receptor blocking drug, to control the sinus tachycardia and increase in arterial blood pressures induced by electroconvulsive therapy (ECT). " 08/01/1999 - "Immediately after surgical incision, the patient developed a sinus tachycardia with ST-segment depression in leads II and III, and ST elevation in leads aVR, aVL, aVF, and V. Depth of anesthesia was increased, esmolol was administered, which slowed the heart rate, and the procedure was terminated. "
6.	PractololIBA 02/01/1986 - "Unlike our earlier identical study without practolol pretreatment, neither sinus tachycardia nor junctional rhythm occurred during microlaryngoscopy in the present study. " 02/01/1986 - "The results suggest that practolol pretreatment before microlaryngoscopy is especially useful when sinus tachycardia and junctional rhythm should be avoided." 09/01/1974 - "Practolol for sinus tachycardia in asthma." 10/01/1984 - "The intravenous use of the cardioselective beta adrenergic blocking agents practolol and metoprolol, in a dose of 0.05-0.22 and 0.16-0.17 mg/kg body weight, respectively, proved effective in the treatment of sinus tachycardia in excess of 150 beats/min and/or ventricular dysrhythmias. "
7.	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)IBA 01/10/1970 - "[Clinical studies and experiences with beta-adrenergic blocking agents in the treatment of sinus tachycardia in children]." 10/01/1984 - "The intravenous use of the cardioselective beta adrenergic blocking agents practolol and metoprolol, in a dose of 0.05-0.22 and 0.16-0.17 mg/kg body weight, respectively, proved effective in the treatment of sinus tachycardia in excess of 150 beats/min and/or ventricular dysrhythmias. "
8.	Clozapine (Clozaril)FDA LinkGeneric 06/01/2014 - "Sinus tachycardia is a common adverse event associated with clozapine use, which may lead to the premature discontinuation of clozapine. " 01/01/2012 - "A 25-year-old male developed sinus tachycardia after given clozapine for treatment-resistant psychosis in schizophrenia. " 06/01/2014 - "Ivabradine, a novel treatment for clozapine-induced sinus tachycardia: a case series." 09/01/2009 - "Beta-adrenergic antagonists for the treatment of clozapine-induced sinus tachycardia: a retrospective study." 03/01/2014 - "Verapamil for the treatment of clozapine-induced persistent sinus tachycardia in a patient with schizophrenia: a case report and literature review."
9.	Calcium Channels (Calcium Channel)IBA 02/01/2013 - "Both patients experienced prolonged sinus tachycardia that, in one patient, was relatively resistant to both beta- and calcium channel blockade. " 11/01/1987 - "The haemodynamic responses after application of 100-200 mg falipamil (5,6-dimethoxy-2-(3-((alpha (3,4-dimethoxy)-phenylethyl) methylamino)propyl)phthalimidine, AQ-A 39) a new calcium channel blocker with specific action on the sinus node, was studied in 11 patients with perioperative sinus tachycardia (greater than 120/min). " 10/01/2001 - "To determine whether an intravenous infusion of the calcium channel blocker diltiazem was effective and safe in treating sinus tachycardia in critically ill adult patients with contraindications to beta-blockers or in whom beta-blockers were ineffective. "
10.	Verapamil (Calan)FDA LinkGeneric 05/01/1984 - "Use of verapamil to control an inappropriate chronic sinus tachycardia." 05/01/1984 - "We report a case in which persistent sinus tachycardia occurring in a patient with severe bronchospastic pulmonary disease was effectively treated with verapamil." 03/01/2014 - "Verapamil for the treatment of clozapine-induced persistent sinus tachycardia in a patient with schizophrenia: a case report and literature review." 01/01/1988 - "In patients with supraventricular tachycardias or sinus tachycardia, verapamil or diltiazem is preferred, whereas in patients with a resting bradycardia or borderline heart failure nifedipine is likely to be chosen."

Therapies and Procedures

1.	Transplants (Transplant) 12/01/2011 - "Sinus tachycardia is common in heart transplant patients due to the lack of autonomic control. " 02/01/2013 - "Sinus tachycardia is more common in heart transplant recipients due to graft denervation. " 01/01/2013 - "Due to graft denervation, sinus tachycardia is a common problem after heart transplantation, underlining the importance of heart rate control without peripheral effects. " 09/27/2009 - "Graft denervation in heart transplant recipients causes sinus tachycardia, occasionally requiring pharmacologic heart rate reduction. " 10/27/2007 - "Graft denervation in heart transplant recipients causes sinus tachycardia, occasionally requiring pharmacologic heart rate reduction. "
2.	Psychology Biofeedback (Biofeedback) 12/01/1977 - "Biofeedback of heart rate has shown some utility in treating premature ventricular contractions and sinus tachycardia. " 06/01/1978 - "For other disorders in which no comparisons have been made (e.g., Raynaud's disease, sinus tachycardia, peptic uclers, and fecal incontinence) biofeedback seems to be a very promising treatment modality." 01/01/1977 - "The results are encouraging, but not yet enough backed up, as to regards to the improvement of various forms of epilepsy by the biofeedback training of the EEG sensorimotor rhythm, the premature ventricular contractions, sinus tachycardia and migraine headaches. "
3.	Intravenous Infusions 10/01/2001 - "To determine whether an intravenous infusion of the calcium channel blocker diltiazem was effective and safe in treating sinus tachycardia in critically ill adult patients with contraindications to beta-blockers or in whom beta-blockers were ineffective. "
4.	Decompression 10/01/1985 - "The improved effort tolerance is attributed to reduction of the exercise-associated sinus tachycardia by beta-blockade, allowing a longer diastolic filling period and better left atrial decompression."
5.	Catheters 08/01/2007 - "We describe a case of inappropriate sinus tachycardia refractory to medical therapy and catheter sinus node ablation, which was successfully treated by surgery with approaches on both the sinus node and cardiac autonomic ganglia." 11/01/1998 - "Radiofrequency (RF) catheter modification of the sinus node appears to be a promising therapeutic modality for the treatment of inappropriate sinus tachycardia. " 10/20/1998 - "A strong relation was observed between catheter and Doppler PCWP (r=0.91), with a mean difference of 0.4+/-2.8 mm Hg. The ratio of transmitral E velocity to Ea can be used to estimate PCWP with reasonable accuracy in sinus tachycardia, even with complete merging of E and A velocities." 03/01/1998 - "[Sinus node modification by catheter using radiofrequency current in a patient with inappropriate sinus tachycardia. " 08/01/1997 - "Radiofrequency catheter modification of sinus node for inappropriate sinus tachycardia: a case report."