Latent Syphilis

01/01/2011 - "Late cutaneous syphilis has become a rarity as a result of the effective treatment of early and latent syphilis with antibiotics. "
03/01/1997 - "Late cutaneous syphilis has become a rarity as a result of effective treatment of early and latent syphilis with antibiotics. "

07/05/1947 - "Effect of penicillin on serology of late and latent syphilis; a study of 120 cases followed for six months or more."
02/01/2015 - "The serofast was positively associated with older age(P trend=0.001), female(summary risk ratio[sRR]=1.50, 95%CI:1.34-;1.68), latent syphilis(sRRlatent vs primary=3.17, 95%CI: 2.66-;3.77; sRRlatent vs secondary=2.00, 95%CI: 1.48-;2.69) as well as non-penicillin treatment(sRR =2.99, 95%CI:2.45-;3.67), but negatively associated with higher baseline titers(sRR>1:32 vs ≤1:32=0.63, 95%CI: 0.54-;0.75). "
10/01/2013 - "All JHRs occurred in patients with secondary and latent syphilis treated with penicillin. "
01/01/1987 - "[Penicillin levels of the blood and cerebrospinal fluid of patients with secondary recurrent and early latent syphilis during treatment by a new accelerated method]."
12/04/1981 - "Cerebrospinal fluid and serum penicillin levels were determined in patients with latent syphilis. "

01/01/1981 - "Eighteen patients with latent syphilis were treated with 360 mg, 720 mg, 1080 mg or 1440 mg intramuscular procaine penicillin daily for 14 days. "
11/01/1992 - "Studies comparing ceftriaxone with 10 to 14 doses of procaine penicillin are needed to determine the most cost-effective treatment for asymptomatic neurosyphilis or presumed latent syphilis in this group of patients."
05/01/1956 - "Penicillin in late latent syphilis; results of therapy with procaine penicillin in aluminum monostearate."

03/01/1993 - "These data suggest that elicitation of a history of cocaine use from urban hospital emergency department patients may be helpful in identifying patients with latent syphilis. "
03/01/1993 - "The goal of this study was to estimate the prevalence of newly diagnosed latent syphilis, as well as previously treated syphilis, in emergency department patients giving a history of cocaine use. "

11/01/1992 - "Although ceftriaxone achieves high serum and CSF levels, 10 to 14 days of treatment with this drug were associated with a 23% failure rate in HIV-infected patients who had latent syphilis or asymptomatic neurosyphilis. "
11/01/1992 - "To evaluate the effect of ceftriaxone in treating latent syphilis or asymptomatic neurosyphilis in patients infected with the human immunodeficiency virus (HIV). "
11/01/1992 - "Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus."
11/01/1992 - "Thirteen patients received benzathine penicillin for presumed latent syphilis; results were similar to those observed after ceftriaxone therapy, with 8 (62%) responders, 1 (8%) serofast, 2 (15%) relapses, and 2 (15%) failures. "
11/01/1992 - "Studies comparing ceftriaxone with 10 to 14 doses of procaine penicillin are needed to determine the most cost-effective treatment for asymptomatic neurosyphilis or presumed latent syphilis in this group of patients."

03/31/2009 - "The seroresistance rate was 8.7% in the primary syphilis patients (2/23), significantly lower than that of the latent syphilis patients (42.2%, 38/90, P = 0.001). "
07/01/2008 - "Case detection was lower for late latent syphilis when compared with primary syphilis based on the properties of the RPR. "
11/01/2006 - "The number of cases with primary syphilis diminished significantly (P<0.001), with a concomitant rise in secondary and early latent syphilis. "
09/01/1995 - "Seropositivity was found in 100% of secondary and early latent syphilis patients, 75% of primary syphilis patients, and 80% of late latent syphilis patients. "
04/01/1990 - "Much of this increase is attributed to concurrent increased rates of primary syphilis and late latent syphilis. "

01/01/2013 - "Anti-syphilis treatment reduced the expression levels of Tp17 IgG and Tp47 IgG. Larger-scale studies are required to further validate the value of Tp15, Tp17, Tp45, and Tp47 as markers for the early detection of primary and latent syphilis."
11/01/1984 - "These results provide the first direct evidence for an IgG complement-mediated treponemicidal mechanism operative in immune serum from rabbits with latent syphilis."
01/01/2013 - "In subjects with tertiary or latent syphilis, the expression levels of Tp45 IgG (121.33 ± 11.04 and 110.10 ± 40.19, respectively) were higher than those of other target TP-IgG. The expression levels of all Tp-IgM were similar before or after anti-syphilis treatment. "
04/01/1988 - "An increased IgG or IgM index, or both, was found about 70 times more often in symptomatic neurosyphilis than in latent syphilis without involvement of the central nervous system. "
05/01/2004 - "The study revealed that primary syphilis was characterized by considerable prevalence of IgG to protein p41 with the total antibody level being low, while early latent syphilis was characterized mainly by considerable prevalence of IgG to protein p17 in the presence of high titers of antibodies. "

02/01/1980 - " Antitreponemal antibodies were detected in 1.4% of patients; all were cases of latent syphilis. "
06/01/1977 - "[Technical advances in demonstration of treponema-specific 19S-IgM antibodies in patients with latent or late-latent syphilis (author's transl)]."
01/01/1989 - "Statistical processing, carried out by the characteristic intervals method, of the results of serologic tests for syphilis in 48 patients with latent syphilis and in 191 patients with false-positive serologic tests has revealed specific and relatively specific intervals of the titers of anti-Treponema antibodies, precipitines and reagines; these intervals make possible a tentative differential diagnosis before specific tests or in cases when these tests cannot be carried out."
06/01/1977 - "In patients with latent or late-latent syphilis as well as neurosyphilis the demonstration of treponema-specific 19S-IgM antibodies is not regularly possible. "
06/01/1989 - "Until 9 to 12 months after treatment, it was seen that there was a loss of several antibodies and some diminution in their reactivity in primary, secondary and early latent syphilis, but no changes occurred in late latent and reinfected syphilis. "

02/01/1985 - "Sera from patients with secondary and early latent syphilis uniformly demonstrated reactivity to 22 separate polypeptide antigens; decreased reactivity was seen in late latent syphilis. "
10/01/1983 - "A similar set of antigens was detected by serum from patients with human secondary and early latent syphilis. "
09/01/1982 - "Those patients studied with secondary and early latent syphilis acquire antibody to a set of 16 additional polypeptide antigens. "
06/01/2013 - "In light of the overwhelming association between a past history of syphilis and HIV seroconversion, more sensitive tools, including recombinant antigen-based immunological tests and direct detection (PCR) technology, are needed to adequately assess the role of latent syphilis in persons with HIV/AIDS. "
09/30/1976 - "Examination was made of 300 serum specimens taken from patients with latent syphilis, in order to study the incidence of HBsAg antigen as compared with the normal population. "

01/01/2012 - "Subgroup analysis by primary and latent syphilis and by dose of azithromycin (2 g and 4 g) did not explain the variation between the study results. "
09/22/2005 - "A total of 328 subjects, 25 with primary and 303 with high-titer (a titer of at least 1:8 on a rapid plasmin reagin [RPR] test) latent syphilis, were recruited through screening of high-risk populations in Mbeya, Tanzania, and randomly assigned to receive 2 g of azithromycin orally (163 subjects) or 2.4 million units of penicillin G benzathine intramuscularly (165 subjects). "
08/01/2012 - "Prospectively enrolled participants in North America and Madagascar with primary, secondary, or early latent syphilis were randomly assigned to penicillin, doxycycline (in the case of penicillin allergy), or azithromycin treatment. "

12/01/2003 - "To observe the changes in peripheral blood lymphocyte subsets in patients with latent syphilis after treatment, who had persistent positive results of test for rapid plasma reagin (RPR) and remained infectious. "
01/01/2016 - "Persistent non-treponemal titres after treatment are common among patients with latent syphilis. "
12/01/2011 - "We compared factors associated with serological response after treatment of early (ie, primary, secondary, or early latent) syphilis. "
06/01/1984 - "Twenty-six patients with secondary or early latent syphilis were examined by auditory brainstem response (ABR) audiometry and by pure tone audiometry before and after treatment. "
02/01/1983 - "The natural killer cell activity was studied in 25 patients with primary, secondary, or latent syphilis before and after treatment. "

02/01/1997 - "In the multivariate analysis, the significant factors for CS were lack of prenatal care and late latent syphilis. "
08/01/2006 - "Delayed or absent prenatal care and misinterpretation of syphilis serology (or laboratory failures) in the presence of latent syphilis are mostly responsible for the inadequate management of syphilis during pregnancy and thus the occurrence of CS."

01/01/2013 - "Late latent syphilis in two hemodialysis units."
04/01/2014 - "After the completion of an oral desensitization protocol, the standard three-dose regimen of intramuscular penicillin G for late latent syphilis was safely administered to a hemodialysis patient without dosage adjustment or repeated desensitization."

01/01/2016 - "In all, 74.3% (26/35) of the cases with latent syphilis who failed to achieve serological cure at 12 months after initial therapy achieved serological cure after retreatment and after an additional 12 months of follow-up. "
01/01/2016 - "We retrospectively analysed the serological response to therapy following retreatment of 35 serofast latent syphilis patients at 12 months with benzathine penicillin 2.4 million units weekly for 3 weeks. "
01/01/2016 - "We compared the serological responses of serofast latent syphilis patients retreated with 7.2 million units of benzathine penicillin with the responses of patients who did not receive retreatment (control group). "

04/01/2014 - "Pharmacotherapy challenges in a case of late latent syphilis complicated by end-stage renal disease and presumptive penicillin allergy are described. "