Cardiovascular Syphilis (Syphilitic Aortitis)

Cardiovascular manifestations of SYPHILIS, an infection of TREPONEMA PALLIDUM. In the late stage of syphilis, sometimes 20-30 years after the initial infection, damages are often seen in the blood vessels including the AORTA and the AORTIC VALVE. Clinical signs include syphilitic aortitis, aortic insufficiency, or aortic ANEURYSM.

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Networked: 63 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pathologic Constriction (Stenosis)
2.	Syphilis
3.	Aortic Valve Insufficiency (Aortic Regurgitation)
4.	Rare Diseases (Rare Disease)
5.	Neurosyphilis (General Paresis of the Insane)

Experts

1.	Ghanem, Khalil G: 1 article (12/2015)
2.	Henry, A Carl: 1 article (10/2015)
3.	Ko, Jong M: 1 article (10/2015)
4.	Weissenborn, Matthew R: 1 article (10/2015)
5.	Barbin, Clay M: 1 article (10/2015)
6.	Roberts, William C: 1 article (10/2015)
7.	Cheng, Zhaoping: 1 article (07/2014)
8.	Bi, Wanli: 1 article (07/2014)
9.	Pfluger, Thomas T: 1 article (07/2014)
10.	Zhao, Shihua: 1 article (07/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cardiovascular Syphilis:

1.	Penicillins (Penicillin)FDA Link 11/03/1951 - "Treatment of cardiovascular syphilis; efficacy of penicillin: studies based on Ill cases." 05/01/1951 - "Penicillin therapy of cardiovascular syphilis with large total dosage; its rationale based on histologic studies." 06/01/1961 - "[Syphilitic aortitis with penicillin]." 01/01/1957 - "Observations on penicillin therapy in cardiovascular syphilis." 03/01/1956 - "[Cardiovascular syphilis; treatment by penicillin]."
2.	IodineIBA 12/10/1949 - "[On the efficacy of iodine and its compounds in cardiovascular syphilis]." 01/01/2000 - "Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... "
3.	Lipoproteins (Lipoprotein)IBA 08/01/1962 - "[Protein composition and lipoproteins in the blood serum in patients with syphilitic aortitis]." 04/01/1964 - "[LIPOPROTEINS AND FREE CHOLESTEROL IN PATIENTS WITH SYPHILITIC AORTITIS]."
4.	CholesterolIBA 01/01/1955 - "[Cholesterol blood level in syphilitic aortitis]." 04/01/1964 - "[LIPOPROTEINS AND FREE CHOLESTEROL IN PATIENTS WITH SYPHILITIC AORTITIS]."
5.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2003 - "Today, however, cardiovascular syphilis is a medical curiosity because the disease can successfully be treated with antibiotics in its early phase. " 10/15/2015 - "The major purpose of that extensively illustrated report was to describe the characteristic gross features of the aneurysm such that syphilitic aortitis might be better recognized at operation and appropriate antibiotics administered postoperatively. "
6.	Aorta-pulmonary artery fistulaIBA 08/01/2012 - "Retrospectively, the diagnosis of syphilitic aortitis complicated with aortopulmonary fistula was made by clinical profile, serology, and histopathology." 11/01/2009 - "Syphilitic aortitis: an uncommon cause of acquired aortopulmonary fistula."
7.	tertiary SyphilisIBA 04/01/2006 - "Cardiovascular syphilis, which used to be a well-recognized manifestation of tertiary syphilis, has become a rarity. " 12/15/2015 - "A cerebrospinal fluid examination to diagnose neurosyphilis is recommended in persons diagnosed with tertiary syphilis (eg, cardiovascular syphilis or late benign syphilis), persons with neurological signs or symptoms consistent with neurosyphilis, and asymptomatic persons whose serological titers do not decline appropriately following recommended therapy and in whom reinfection is ruled out. "
8.	Ethiodized Oil (Ethiodol)FDA Link 01/01/2000 - "Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... "
9.	Carbon MonoxideIBA 04/20/1951 - "[Cardio-vascular disorders of acute carbon monoxide intoxication; case of syphilitic aortitis, with sudden decompensation, of this origin]."
10.	BismuthIBA 04/01/1953 - "[Comparative evaluation of the treatment of cardiovascular syphilis with penicillin and bismuth compounds]."

Therapies and Procedures

1.	Transplants (Transplant) 02/01/2003 - "CABG should be performed with ITA, not saphenous vein grafts, to avoid occlusion of the ostium of the saphenous vein graft by syphilitic aortitis. " 07/01/2014 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft was then performed. " 01/01/1998 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft and aortic valve replacement were then performed. "
2.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 07/01/2014 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft was then performed. " 01/01/1998 - "We report here a case in which bilateral coronary ostial stenosis and aortic regurgitation due to syphilitic aortitis was diagnosed; coronary artery bypass graft and aortic valve replacement were then performed. "
3.	Stents 09/01/2013 - "Bilateral coronary ostial stenosis with bilateral renal ostial stenosis in cardiovascular syphilis: de novo percutaneous coronary intervention and in-stent restenosis."