Pigmented Villonodular Synovitis

Outgrowths of synovial membrane composed of villi and fibrous nodules characterized histologically by hemosiderin- and lipid-containing macrophages and multinucleated giant cells. It usually occurs in the knee.

Also Known As:

Networked: 128 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Giant Cell Tumors (Giant Cell Tumor)
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease)
3.	Synovitis
4.	Rheumatoid Arthritis
5.	Osteoarthritis

Experts

1.	He, Jin: 3 articles (03/2015 - 02/2011)
2.	Pagnin, E: 3 articles (05/2011 - 10/2006)
3.	Sfriso, P: 3 articles (05/2011 - 10/2006)
4.	Calabrese, F: 3 articles (05/2011 - 10/2006)
5.	Nardacchione, R: 3 articles (05/2011 - 10/2006)
6.	Oliviero, F: 3 articles (05/2011 - 10/2006)
7.	Rubaltelli, L: 3 articles (05/2011 - 10/2006)
8.	Fiocco, U: 3 articles (05/2011 - 10/2006)
9.	Cassier, Philippe A: 2 articles (08/2015 - 03/2012)
10.	Blay, Jean-Yves: 2 articles (08/2015 - 03/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pigmented Villonodular Synovitis:

1.	HemosiderinIBA 12/01/2015 - "Pigmented villonodular synovitis is a disorder resulting in a villous, nodular, or villonodular proliferation of the synovium, with pigmentation related to the presence of hemosiderin. " 12/01/2013 - "Pigmented villonodular synovitis (PVNS) is a proliferative disease of synovial tissue characterized by lipid-laden macrophages, multinucleated giant cells, and hemosiderin deposits. " 01/01/2013 - "Histopathological examination of the resected specimen confirmed the diagnosis of localized pigmented villonodular synovitis, with the mass consisting of proliferation of fibrohistiocytic cells, abundant hemosiderin, foamy histiocytes, and occasional giant cells. " 09/01/2009 - "Microscopic examination of a specimen procured using fine-needle biopsy revealed multinucleated giant cells, hemosiderin deposition, and foaming histiocytes, indicative of pigmented villonodular synovitis. " 10/01/2007 - "Pigmented villonodular synovitis (PVNS) is a benign but potentially aggressive lesion, characterized by synovial villonodular proliferation with hemosiderin pigmentation and stromal infiltration of histiocytes and giant cells. "
2.	YttriumIBA 02/01/1987 - "Yttrium 90 synovectomy--a new treatment for pigmented villonodular synovitis." 08/01/2008 - "Pigmented villonodular synovitis managed by Yttrium 90 after debulking surgery." 02/01/2008 - "Because of the unacceptably high rate of serious complications associated with the injection of yttrium 90 into the ankle joint following subtotal synovectomy, we discontinued its use as a local adjuvant in the management of diffuse pigmented villonodular synovitis of the ankle." 02/01/2008 - "Our initial and highly satisfactory experience with the injection of radioactive yttrium 90 to treat pigmented villonodular synovitis of the ankle joint eroded with time so much so that we discontinued its use in the ankle and believe that it is important to alert our colleagues to the complications that we observed. " 10/01/2002 - "The use of surgery and yttrium 90 in the management of extensive and diffuse pigmented villonodular synovitis of large joints."
3.	imatinib (Gleevec)FDA Link 01/01/2016 - "Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells." 04/01/2011 - "Pigmented villonodular synovitis responsive to imatinib therapy." 03/15/2012 - "Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis." 04/01/2008 - "Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT)." 06/01/2010 - "The identification of these abnormal ways of road marking to licence the development of effective targeted therapeutic agents against certain rare histological connective subcategories of sarcomas and tumors with local aggressiveness, in particular DFSP, PVNS, GCST, PEComes, endometrial stromal sarcomas, Ewing sarcomas, etc. Imatinib is used in the treatment of DFSP, characterized by a translocation of the gene PDGF, or in pigmented villonodular synovitis (PVNS), a tumor of soft part also locally aggressive, caused by an abnormality of the gene coding for the M-CSF. "
4.	SteroidsIBA 01/01/2011 - "Although her systemic lupus erythematosus went into remission with another course of steroids and higher doses of mycophenolate mofetil, the pigmented villonodular synovitis persisted and she had to undergo open synovectomy to control her symptoms. "
5.	mycophenolate mofetil (Cellcept)FDA LinkGeneric 01/01/2011 - "Although her systemic lupus erythematosus went into remission with another course of steroids and higher doses of mycophenolate mofetil, the pigmented villonodular synovitis persisted and she had to undergo open synovectomy to control her symptoms. "
6.	IronIBA 01/01/1998 - "[Iron deposits, cell populations and proliferative activity in pigmented villonodular synovitis of the knee joint]." 11/01/1979 - "Pigmented villonodular synovitis is a rare lesion in which iron is accumulated. " 11/01/1979 - "Iron content of pigmented villonodular synovitis detected by computed tomography." 03/01/2004 - "Iron pigment deposition and inflammation are mild to absent, making synovial excrescences different from pigmented villonodular synovitis. " 01/01/1986 - "A detailed ultrastructural study was made of the synovial iron deposits in cases of haemophilic synovitis (HS), pigmented villonodular synovitis (PVNS), rheumatoid arthritis (RA), osteoarthritis (OA), seronegative inflammatory arthritis (SNA), and in controls, to investigate the relationship between iron deposits and tissue damage. "
7.	ParaffinIBA 11/01/2001 - "Osteoarthritis (OA) and pigmented villonodular synovitis (PVNS) are disorders associated with trisomy 7. The aim of the present study was to determine the frequency and distribution of the cells with +7 in vivo by analyzing sections of paraffin-embedded synovia from patients affected by OA, PVNS, other forms of synovitis [hemorragic synovitis (HS) and chronic synovitis (CS)], and from individuals without joint disease. " 04/01/2008 - "Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma. " 12/01/2004 - "Using a monoclonal antibody with a standard immunohistochemical technique on paraffin sections, we evaluated expression of Mitf in 89 various giant cell lesions including giant cell tumor of bone (n26), giant cell tumor of tendon sheath/pigmented villonodular synovitis (n24), giant cell reparative granuloma (n3), aneurysmal bone cysts (n11), chondroblastomas (n7), foreign body giant cell reaction (n10), and sarcoidosis (n8). "
8.	Amyloid (Amyloid Fibrils)IBA 10/01/2000 - "Such disorders include gout, Milwaukee shoulder, rapidly destructive articular disease, amyloid arthropathy, hemophilic arthropathy, primary synovial osteochondromatosis, pigmented villonodular synovitis, neuropathic arthropathy, and foreign-body synovitis. " 07/01/2014 - "X-ray and histological studies should be performed for its differential diagnosis with pigmented villonodular synovitis, synovial chondromatosis, synovial hemangioma, xanthoma, a group of chronic synovitis in rheumatic diseases (rheumatoid arthritis, amyloid arthropathy, psoriatic arthritis). " 01/01/2005 - "Intraarticular masses can be classified as noninfectious synovial proliferative processes (lipoma arborescens, synovial osteochondromatosis, pigmented villonodular synovitis, rheumatoid arthritis), infectious granulomatous diseases (tuberculous arthritis, coccidioidomycosis arthritis), deposition diseases (gout, amyloid arthropathy), vascular malformations (synovial hemangioma, arteriovenous malformations), malignancies (synovial chondrosarcoma, synovial sarcoma, synovial metastases), and miscellaneous (cyclops lesion). "
9.	ThalliumIBA 12/01/2015 - "MRI and thallium features of pigmented villonodular synovitis and giant cell tumours of tendon sheaths: a retrospective single centre study of imaging and literature review." 11/01/2003 - "The purpose of this report was to determine the pattern of thallium (T1-201) uptake in pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCTTS) and to evaluate for features that might help to distinguish these lesions from malignant disease. "
10.	tebufenozide (Mimic)IBA 03/01/2015 - "Intra-articular post-traumatic ankle joint mass is a rare entity that may mimic other pathologies, mainly localized form of pigmented villonodular synovitis (LPVS) regarding the clinical and imaging characteristics. " 08/01/2003 - "Localised pigmented villonodular synovitis can mimic symptoms of a meniscal tear." 12/01/2014 - "Specifically, monoarticular tuberculosis of the knee may mimic pigmented villonodular synovitis (PVNS). " 05/01/2012 - "Specifically, monoarticular tuberculosis of the knee may mimic pigmented villonodular synovitis (PVNS). " 05/01/2008 - "In fact, synovial chondromatosis, pigmented villonodular synovitis, synovial hemangioma, and lipoma arborescens often mimic each other as well as other, more common joint disorders in presentation, making diagnosis extremely difficult. "

Therapies and Procedures

1.	Arthroplasty 07/01/1999 - "In our series of 1136 patients with 1388 arthroplasties, these costs could have been eliminated for all but the twelve patients who had a suspected malignant lesion and the one patient in whom pigmented villonodular synovitis was found. " 01/01/2014 - "Unusual cases of pigmented villonodular synovitis after arthroplasty." 02/01/2013 - "MRI diagnosis of recurrent pigmented villonodular synovitis following total joint arthroplasty." 09/01/2011 - "In this report, we describe a case of diffuse pigmented villonodular synovitis that presented in the knee 18 months after total knee arthroplasty. " 09/01/2011 - "A rare case of diffuse pigmented villonodular synovitis after total knee arthroplasty."
2.	Radiotherapy 07/01/2015 - "This retrospective observational study aims to explore the treatment procedure and outcomes of arthroscopically assisted radiotherapy for diffuse pigmented villonodular synovitis (PVNS) of the knee joint. " 09/01/2012 - "The objective of this study was to evaluate the effectiveness and long-term outcome of the treatment of patients with diffuse pigmented villonodular synovitis (PVNS) of the knee with subtotal arthroscopic and open synovectomy and subsequent external-beam radiotherapy. " 09/01/2010 - "The German Cooperative Group on Radiotherapy in Benign Diseases (GCG-BD) conducted a pattern-of-care study (PCS) to analyze the radiation therapy (RT) practice for pigmented villonodular synovitis (PVNS). " 07/01/2015 - "Arthroscopic Synovectomy and Postoperative Assisted Radiotherapy for Treating Diffuse Pigmented Villonodular Synovitis of the Knee: An observational retrospective study." 04/01/2015 - "The effect of surgical synovectomy and radiotherapy on the rate of recurrence of pigmented villonodular synovitis of the knee: an individual patient meta-analysis."
3.	Homologous Transplantation (Allograft) 06/01/2004 - "This case report describes the long-term outcome of a total bulk acetabular allograft placed for bone substitution after resection of recurrent pigmented villonodular synovitis of the hip joint. " 01/01/1991 - "A case report of recurrent pigmented villonodular synovitis of the hip joint, which was treated with en bloc resection of the acetabulum and proximal femur, followed by allograft acetabular reconstruction and total hip arthroplasty, is presented. "
4.	Osteotomy 09/01/2015 - "Transtrochanteric rotational osteotomy combined with intra-articular procedures for pigmented villonodular synovitis of the hip." 04/01/1992 - "Role of upper tibial osteotomy in pigmented villonodular synovitis of the knee."
5.	Intra-Articular Injections 02/01/2008 - "Between 1989 and 2006, we treated seven patients who had diffuse pigmented villonodular synovitis of the ankle joint with subtotal synovectomy followed by intra-articular injection of 15 mCi of yttrium 90. " 02/01/2008 - "Unacceptable complications following intra-articular injection of yttrium 90 in the ankle joint for diffuse pigmented villonodular synovitis." 12/01/1989 - "The diffuse form of pigmented villonodular synovitis of eight knee joints of eight patients was treated by intra-articular injection of 185 MBq yttrium-90 silicate (90Y). "