Synovial Sarcoma (Synovioma)

A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)

Also Known As:

Networked: 794 relevant articles (33 outcomes, 108 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Sarcoma (Soft Tissue Sarcoma)
3.	Liposarcoma
4.	Leiomyosarcoma
5.	Nerve Sheath Neoplasms (Nerve Sheath Neoplasm)

Experts

1.	Nielsen, Torsten O: 14 articles (04/2015 - 10/2003)
2.	Oda, Yoshinao: 11 articles (10/2013 - 04/2002)
3.	Toguchida, Junya: 11 articles (09/2012 - 10/2002)
4.	Ladanyi, Marc: 10 articles (02/2015 - 02/2002)
5.	Kawai, Akira: 10 articles (04/2013 - 08/2002)
6.	Saito, Tsuyoshi: 10 articles (01/2013 - 04/2002)
7.	Wang, Jian: 10 articles (07/2008 - 07/2002)
8.	Araki, Nobuhito: 9 articles (09/2014 - 08/2002)
9.	Iwamoto, Yukihide: 9 articles (10/2013 - 04/2002)
10.	Tsuneyoshi, Masazumi: 9 articles (06/2012 - 04/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Synovial Sarcoma:

1.	IfosfamideFDA LinkGeneric 03/01/2011 - "Synovial sarcomas appear to have significant sensitivity to ifosfamide, even on re-challenge. " 07/01/2007 - "Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients." 03/15/2008 - "Although ifosfamide based chemotherapy has been associated with an improved survival in patients with synovial sarcoma, the search for less toxic and more targeted systemic therapies is ongoing." 10/01/2002 - "Studies in the last 10 years have shown it to be extremely sensitive to ifosfamide-based chemotherapy, and survival of patients with synovial sarcoma has recently increased with chemotherapy, with 5-year survivals now as high as 57%.(8-10) In this report, we describe 3 cases of synovial sarcoma of the pleura. " 05/13/2014 - "Contemporary management of renal synovial sarcoma includes surgical resection and ifosfamide-based chemotherapy and they remain the mainstay of therapy of synovial sarcoma, which is often applied, combined as part of an aggressive treatment approach. "
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 07/01/2011 - "This study evaluated the function of TLE1 in synovial sarcomas using knock-down of TLE1, and examined whether the inhibition of TLE1 suppresses the proliferation of synovial sarcomas and enhances the cytotoxicity caused by doxorubicin (doxo). " 06/01/2006 - "Likely, both apoptosis and cell senescence contribute to doxorubicin-induced cell death in this synovial sarcoma cell line." 06/01/2006 - "Doxorubicin induces cell senescence preferentially over apoptosis in the FU-SY-1 synovial sarcoma cell line." 05/01/1984 - "A 42-year-old woman with synovial sarcoma developed a skin flare during doxorubicin therapy. " 01/01/1990 - "Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity. "
3.	AntigensIBA 12/01/2012 - "These results suggest that future similar studies might best evaluate patients with a lower burden of disease, consider alternative immunization approaches to the SYT-SSX target antigen and consider the efficacy of IFN-α alone for the treatment of synovial sarcoma." 01/01/2013 - "Despite high expression of CT antigens by synovial sarcomas of patients treated in this study, there was neither clinical benefit nor evidence of anti-CT antigen serological responses. " 03/04/2003 - "Sera from these two patients were used to immunoscreen cDNA libraries from two synovial sarcoma cell lines and normal testis, resulting in the identification of 113 distinct antigens. " 02/01/2002 - "MAGE antigen expression in monophasic and biphasic synovial sarcoma." 10/15/2001 - "Previous analysis revealed a high incidence and homogeneous expression of MAGE CT antigen in synovial sarcomas. "
4.	Proteins (Proteins, Gene)IBA 05/01/2007 - "For this reason, we assessed the efficacy of immunostaining for SYT and SSX1 proteins, the gene products resulting from unique synovial sarcoma translocation, to distinguish synovial sarcoma from other soft tissue lesions. " 08/01/2011 - "Immunohistochemical study of correlation between histologic subtype and expression of epithelial-mesenchymal transition-related proteins in synovial sarcomas." 11/01/2002 - "The objective of this study was to evaluate synovial sarcomas for the expression of oncogenic proteins (Her2/neu, EGFR, Bcl-2, p53) and proliferation markers (Ki-67, Topoisomerase 2alpha), as possible markers of prognostic significance. " 01/01/2001 - "Together, these studies have provided mechanistic clues about how the SYT-SSX fusion proteins may trigger synovial sarcoma development." 01/01/2013 - "The correlation between morphology and the expression of TGF-β signaling pathway proteins and epithelial-mesenchymal transition-related proteins in synovial sarcomas."
5.	AntibodiesIBA 03/15/1991 - "The different cell types constituting synovial sarcoma could be demonstrated by conventional light microscopic study, but more readily so by immunohistochemical study, particularly when antibodies against cytoskeletal components were applied. " 07/01/2009 - "TLE1 may be of value in the differential diagnosis of synovial sarcoma, but should be used only in the context of a panel of antibodies. " 02/01/2007 - "Both antibodies gave intense and/or diffuse nuclear staining in 91/94 molecularly confirmed synovial sarcomas. " 09/15/2005 - "Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas." 03/01/1994 - "In conclusion, we found that proper identification of epithelial differentiation in synovial sarcomas is facilitated by an immunohistochemical application of anti-epithelial antibodies. "
6.	MicroRNAs (MicroRNA)IBA 01/01/2015 - "Validation of the miRNA panel in an independent cohort of synovial sarcoma patients confirmed higher expression levels compared to healthy controls and patients in complete remission. " 01/01/2015 - "A panel of seven miRNAs (miR-99a-5p, miR-146b-5p, miR-148b-3p, miR-195-5p, miR-223-3p, miR-500b-3p and miR-505-3p) was further validated by qRT-PCR to be significantly upregulated in synovial sarcoma patients. " 01/01/2015 - "Unsupervised hierarchical clustering of the miRNA arrays separated patients with active synovial sarcoma from healthy controls. " 01/01/2015 - "Identification of a blood-borne miRNA signature of synovial sarcoma." 09/01/2014 - "We transfected the OncomiR miRNA Precursor Virus Library into synovial sarcoma Fuji cells followed by a colony formation assay to identify miRNAs to confer an aggressive tumorigenicity, and identified miR-17-5p from the large colonies. "
7.	trabectedin (ecteinascidin 743)IBA 07/01/2015 - "The aim of this retrospective analysis was to study the efficacy of trabectedin in the subgroup of synovial sarcomas. " 11/01/2014 - "We believe that trabectedin represents an attractive option for the treatment of metastatic synovial sarcoma and further clinical studies are warranted." 01/01/2015 - "In treatment of recurrent synovial sarcoma, the best objective response (partial response) and longest disease control (37 months) was achieved under treatment with trabectedin. " 07/01/2015 - "Trabectedin is a therapeutic option for palliative treatment of a subset of patients with metastatic synovial sarcoma. " 07/01/2015 - "Trabectedin in advanced synovial sarcomas: a multicenter retrospective study from four European institutions and the Italian Rare Cancer Network."
8.	ParaffinIBA 03/01/2006 - "Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma. " 12/01/2011 - "Paraffin-embedded specimens from 27 patients with synovial sarcoma who were treated with surgical resection or biopsy were obtained. " 09/01/2007 - "FISH may serve as an adjunctive diagnostic tool in problematic cases of synovial sarcoma and can be applied in paraffin-embedded tissue samples. " 09/01/2007 - "Interphase FISH was carried out in paraffin-embedded tissue of 42 cases of synovial sarcoma and 9 cases of non-synovial sarcoma, using a LSI SYT (18q11.2) dual color break-apart probe. " 09/01/2007 - "To evaluate the application of fluorescence in-situ hybridization (FISH) in detection of gene translocation in paraffin-embedded tissue samples of synovial sarcoma. "
9.	SYT-SSX fusion proteinIBA 05/15/1995 - "PCR analysis demonstrates the presence of SYT-SSX1 or SYT-SSX2 fusion transcripts in 29 of 32 of the synovial sarcomas examined, indicating that the detection of these hybrid transcripts by PCR may represent a very useful diagnostic method. " 01/01/2009 - "This study demonstrates deregulation of polycomb activity by the synovial sarcoma-associated SYT-SSX2 oncogene, also known as SS18-SSX2. " 06/01/2004 - "Previous studies have shown that SYT-SSX1 is the most common SYT-SSX fusion transcript in biphasic synovial sarcomas of the limbs. " 08/22/2002 - "A recent large multi-centre study convincingly confirmed previous observations that the SYT-SSX1 fusion type, compared to SYT-SSX2, of synovial sarcoma is associated with a worse clinical outcome. " 01/01/2013 - "The SYT-SSX fusion protein and histological epithelial differentiation in synovial sarcoma: relationship with extracellular matrix remodeling."
10.	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/01/2009 - "The current diagnostic gold standard for synovial sarcoma is the demonstration of the translocation by fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction, or cytogenetics, in an appropriate histologic context. " 02/01/2011 - "Reverse transcriptase polymerase chain reaction and fluorescence in situ hybridization studies were negative for a molecular evidence of synovial sarcoma. " 07/01/2008 - "This study aimed to evaluate the diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma (SS) in known and potential cases. " 01/01/2004 - "The purpose of our study was to assess microinvasion in a case of synovial sarcoma by means of the reverse transcriptase polymerase chain reaction (RT-PCR) for detecting SYT-SSX fusion transcripts. " 02/01/2002 - "This study was performed to analyze the expression of MAGE by immunohistochemistry with mAb 57B in 25 synovial sarcomas (12 monophasic, 13 biphasic), which were typed for the t(X;18)-derived fusion transcript by reverse transcriptase polymerase chain reaction (19 SYT-SSX1, 6 SYT-SSX2). "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 03/01/2001 - "High-grade synovial sarcoma assessed by a histologic grading system based on the proliferative activity of the neoplastic cells can be viewed as high risk with the patients most likely to die of disease within 10 years after surgery and in need of improved chemotherapy. " 07/01/2007 - "Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma." 03/01/2015 - "This research aims to investigate the potential of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET) to predict pathologic response after neoadjuvant chemotherapy (NAC) and overall survival (OS) of patients with synovial sarcoma in Korea. " 01/01/2014 - "Wide excision or marginal excision, followed by radiation therapy combined with chemotherapy, represent acceptable treatment strategies for synovial sarcoma of the hand. " 01/01/2014 - "This is only the third documented case of primary pulmonary synovial sarcoma occurring during pregnancy and the first case where chemotherapy was given. "
2.	Radiotherapy 02/01/2015 - "Perioperative radiotherapy is associated with improved survival among patients with synovial sarcoma: A SEER analysis." 12/15/2011 - "The aim of this analysis was to identify if the modified indications of radiotherapy (RT) or radical surgery compromised survival in pediatric synovial sarcoma (SS). " 01/01/2011 - "[Excellent response to external radiotherapy of a primary synovial sarcoma of the parotid gland]." 01/01/2011 - "The patient was operated and the histopathological diagnosis of synovial sarcoma was made, after which he received radiotherapy with no recurrence after 20 months. " 11/15/2007 - "To evaluate prognostic factors and treatment outcomes in patients with localized synovial sarcoma treated with conservation surgery and radiotherapy (RT). "
3.	Lasers (Laser) 08/01/2001 - "Identification of syt-ssx fusion transcripts in both epithelial and spindle cell components of biphasic synovial sarcoma in small tissue samples isolated by membrane-based laser microdissection." 04/01/2000 - "Detection of SYT-SSX fusion transcripts in both epithelial and spindle cell areas of biphasic synovial sarcoma using laser capture microdissection." 12/01/1997 - "The subcellular localization of Bcl-2 protein in surgically resected, fixed-frozen tissue specimens of seven tumors from six cases of synovial sarcoma and a synovial sarcoma cell line was examined using laser-scanning confocal microscopy and immunoelectron microscopy. " 12/01/2003 - "In this study, 12 cases of well-defined sarcomas including Ewings sarcoma/primitive neuroectodermal tumors (ES/PNET), synovial sarcoma (SS), alveolar rhabdomyosarcoma (ARMS), and desmoplastic small round cell tumors (DSRCT) were used to collect specific numbers of cells by laser capture microdissection (LCM), subsequently used for RT-PCR to detect specific chimeric gene transcripts. " 07/01/2008 - "Our results suggest PDT using ATX-S10.Na(II) and laser irradiation may be a potentially useful treatment for synovial sarcoma, especially to reduce the surgical margin and preserve critical anatomic structures adjacent to the tumor."
4.	Adjuvant Chemotherapy 11/01/1994 - "A controlled trial of adjuvant chemotherapy is merited in children with resected synovial sarcoma (clinical group I or II) who present with unfavorable clinicopathologic features such as large, invasive, or grade 3 lesions. " 08/01/2012 - "The role of adjuvant chemotherapy (AC) in treatment of synovial sarcoma remains controversial. " 01/01/1999 - "The role of postoperative radiotherapy and adjuvant chemotherapy in the treatment of synovial sarcoma remains to be determined. " 03/01/2009 - "Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group." 04/01/2005 - "There are currently no randomized studies of therapy for patients with synovial sarcoma, but such are needed to provide answers to the following questions: Is adjuvant chemotherapy useful in preventing recurrence in patients without visible residual disease after apparently complete surgical removal of localized tumor? "
5.	Heterologous Transplantation (Xenotransplantation) 03/01/2004 - "A poorly differentiated synovial sarcoma (SYT/SSX1) expresses neuroectodermal markers: a xenografts and in vitro culture study." 07/01/2011 - "Cell culture and xenograft research with synovial sarcoma cell lines have identified some critical pathways that may be targetable. " 03/01/2011 - "An easily established in vivo xenograft model of synovial sarcoma is presented." 03/01/2011 - "Histological and immunohistochemical staining confirmed the mouse xenografts as synovial sarcoma. " 10/01/2006 - "This paper discusses the diversity of synovial sarcomas (SSs) [biphasic (BSS), monophasic fibrous (MFSS), and poorly differentiated (PDSS)] and tissue microarray (TMA) evaluation of the immunophenotypic and histological progression of SSs in nude mice using three TMAs comprising 11 primary SSs (8 MFSSs, 2 BSSs, and 1 PDSS) and their xenografts. "