Sympatholytics

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

Also Known As:

Networked: 121 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ng, Tien M H: 1 article (01/2016)
2.	Chao, James Y: 1 article (01/2016)
3.	McComb, Meghan N: 1 article (01/2016)
4.	Nelson, Alexander: 1 article (01/2015)
5.	Martin, Daniel S: 1 article (01/2015)
6.	Ackland, Gareth L: 1 article (01/2015)
7.	Whittle, John: 1 article (01/2015)
8.	Sneyd, J Robert: 1 article (01/2015)
9.	Stephens, Robert C M: 1 article (01/2015)
10.	Otto, James M: 1 article (01/2015)

Related Diseases

1.	Hypertension (High Blood Pressure) 08/01/2004 - "Central sympatholytic drugs for the treatment of hypertension: back to the future?" 01/01/1992 - "Other methods to examine sympathetic activity, such as blood pressure response to sympatholytic agents, measurement of regional sympathetic activity, vascular reactivity to sympathetic agonists, power spectral analysis, and microneurography, have all provided further evidence for enhanced sympathetic activity in essential hypertension, especially in younger subjects. " 08/01/1991 - "Use of centrally acting sympatholytic agents in the management of hypertension." 01/01/1991 - "Sympatholytic drugs and cardiac remodelling in human and experimental arterial hypertension." 08/30/1985 - "Combination therapy with low-dose diuretic and sympatholytic drugs was effective and well tolerated in patients with cardiac and vascular sequelae of moderately severe hypertension."
2.	Cardiovascular Diseases (Cardiovascular Disease) 08/01/2001 - "This beneficial effect may be useful for the treatment of patients with cardiovascular disease including hypertension especially in combination therapy with sympatholytic agents and inhibitors of the renin-angiotensin system." 10/01/1990 - "The failure of diuretics and vasodilators to influence cardiovascular disease favorably appears due not to their known adverse effects on risk factors, such as lipids, as some have held, but to a failure - in conjunction with some sympathetic blocking agents - to cause effective regression of left ventricular hypertrophy, the keystone of successful therapy. " 01/01/1998 - "The association between drug use and low blood pressure was examined for drugs with known potential hypotensive effects (sympatholytic drugs, diuretics, beta-receptor blocking drugs, calcium antagonists, angiotensin-converting enzyme inhibiting drugs, nitrates, antiparkinsonian drugs, neuroleptics, anxiolytics, sedatives-hypnotics and antidepressant drugs) in a logistic regression model controlling for the possible confounders age, gender, housing, dementia status, cardiovascular disease, body mass index and dehydration. "
3.	Weight Loss (Weight Reduction) 05/01/2010 - "The present report will provide a brief update of this topic with a particular emphasis on human studies examining the efficacy of novel pharmacological approaches (central sympatholytics and statins), lifestyle modification (aerobic exercise training, weight loss and stress reduction) and surgical intervention (renal denervation, chronic carotid baroreflex stimulation and deep brain stimulation) in reducing excessive central sympathetic activation in hypertension."
4.	Raynaud Disease (Raynaud's Disease) 01/09/1982 - "The treatment of Raynaud's disease may be improved by using topical glyceryl trinitrate ointment as an adjunct to a basic regimen of oral sympatholytic agents. " 01/09/1982 - "The effects of topical glyceryl trinitrate in Raynaud's disease were compared with those of placebo in a double-blind, crossover trial in 17 patients with bilateral Raynaud's disease and an associated collagen disease, who were receiving oral sympatholytic agents at the maximum levels they could tolerate. "
5.	Ganglion Cysts (Ganglion) 08/01/1963 - "THE EFFECTS OF GANGLION-BLOCKING AND POSTGANGLIONIC SYMPATHOLYTIC DRUGS ON PREPARATIONS OF THE GUINEA-PIG VAS DEFERENS." 01/01/1987 - "Throughout the observed period the leading positions were held by diuretics and beta-blockers, whereas central sympatholytics and ganglion blockers nearly disappeared. " 08/01/1962 - "[The effect of sympathomimetics, sympatholytics and ganglion-blocking agents on the catecholamine (C substance) level of the blood]." 01/01/2000 - "The postural hypotension caused by sympatholytic agents is about double in hypertensive rabbits, and N-type calcium-channel blockade is as effective as ganglion blockade at inducing this syndrome." 06/01/1963 - "Eledoisin is active at extremely low dose levels and hypotension is not appreciably affected by previous treatment with atropine, sympatholytic drugs, ganglion-blocking agents or reserpine. "

Related Drugs and Biologics

1.	Vasodilator Agents (Vasodilators)
2.	Nitroglycerin (Dynamite)
3.	Diuretics
4.	Baclofen
5.	N-Type Calcium Channels (N-Type Calcium Channel)
6.	Lipids
7.	Capsaicin (Zostrix)
8.	Botulinum Toxins (Botulinum Toxin)
9.	resiniferatoxin
10.	Oxygen

Related Therapies and Procedures

1.	Denervation
2.	Deep Brain Stimulation
3.	Renal Dialysis (Hemodialysis)
4.	Drug Therapy (Chemotherapy)
5.	Replantation