Surface-Active Agents (Surfactants)

Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.

Also Known As:

Networked: 431 relevant articles (24 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eckmann, David M: 5 articles (09/2013 - 01/2004)
2.	Notter, Robert H: 5 articles (05/2008 - 12/2004)
3.	Wang, Zhengdong: 5 articles (05/2008 - 12/2004)
4.	Inami, Yoshihiro: 4 articles (11/2014 - 01/2012)
5.	Armstead, Stephen C: 4 articles (09/2013 - 07/2004)
6.	Chang, Yusuo: 4 articles (10/2007 - 12/2004)
7.	Warshaw, Erin M: 3 articles (11/2015 - 06/2006)
8.	Gong, Changyang: 3 articles (02/2015 - 09/2012)
9.	Deng, Senyi: 3 articles (02/2015 - 09/2012)
10.	Wei, Yuquan: 3 articles (02/2015 - 09/2012)

Related Diseases

1.	Lung Injury 10/01/2011 - "These results suggest that improved formulations of lung surfactants are possible and may be useful in reducing some types of surfactant inactivation in treating lung injuries." 10/01/2011 - "In this study, ARDS was developed in rats by intratracheal instillation of LPS and the effect of two types of surfactant (natural vs. synthetic) was examined to determine their potential corrective roles in general, as well as to compare the two surfactants against one another in particular, in endotoxin-induced lung injury. " 03/02/2010 - "This approach and the described platform will enable systematic investigation of the effect of different degrees of fluid mechanical stresses on lung injury at the cellular level and administration of exogenous therapeutic surfactants." 04/01/2001 - "Lung injury was induced in adult rabbits via intratracheal instillation of 0.2 N HCl followed by conventional mechanical ventilation (CMV) until Pa(O2)/FI(O2) values ranged from 220 to 270 mm Hg. Subsequently, animals were given one of three surfactants administered via three different methods and physiological responses were assessed over a 1-h period. " 01/01/2009 - "It is possible that in the next future anti-inflammatory and anti-oxidant properties of exogenous natural surfactants may be improved through their combination with adequate agents with the aim of counteracting the pathogenetic role of inflammatory and oxidative lung injury injuries in the development of brochopulmonary dysplasia."
2.	Newborn Respiratory Distress Syndrome 01/01/2005 - "Exogenous surfactants have been used as an effective treatment of neonatal respiratory distress syndrome (RDS). " 01/01/1987 - "Several recent reports have documented the efficacy of surfactants replacement therapy in the neonatal respiratory distress syndrome (RDS). " 02/01/2009 - "Animal-derived surfactants for the treatment and prevention of neonatal respiratory distress syndrome: summary of clinical trials." 11/01/1993 - "A multicenter randomized trial comparing two surfactants for the treatment of neonatal respiratory distress syndrome. " 04/01/2007 - "Aerosolized surfactants for neonatal respiratory distress syndrome may prevent the need for endotracheal intubation. "
3.	Lung Diseases (Lung Disease) 01/01/2000 - "Comparative clinical trials are required to evaluate the efficacy of these new artificial surfactants in various forms of neonatal lung disease." 01/01/2009 - "In the one trial comparing protein containing synthetic surfactants compared to protein free synthetic surfactant for the prevention of RDS, no statistically different clinical differences in death and chronic lung disease were noted. " 01/01/2007 - "In two trials of protein containing synthetic surfactants compared to animal derived surfactant extract, no statistically different clinical differences in death and chronic lung disease were noted. " 01/01/2007 - "In two trials of protein containing synthetic surfactants compared to animal derived surfactant extract, no statistically different clinical differences in death and chronic lung disease were noted. " 11/01/2010 - "Surfactants deficiency or dysfunction is associated with occurrence and development of many pulmonary diseases. "
4.	Acute Lung Injury 11/01/2001 - "We hypothesize that the surfactants most resistant to inactivation in vitro will be the ones that are most effective in treatment of animal models of acute lung injury. " 07/01/1998 - "We conclude that dilute surfactants administered by lung lavage are effective in reversing pulmonary dysfunction after acute lung injury. " 01/01/2002 - "New requirements must be considered when designing trials of new lung surfactants for patients with acute lung injury (ALI). " 07/01/2012 - "In acute lung injury, intrinsic surfactants are inactivated via albumin leakage and other mechanisms. " 01/01/2002 - "The future of surfactant therapy for patients with acute lung injury - new requirements and new surfactants."
5.	Infection 01/01/2013 - "These findings substantiate that quorum sensing and surfactants have widespread importance for biofilm maturation processes in bacteria and establish a novel theory of the molecular determinants driving dissemination of biofilm-associated infection." 03/01/2005 - "Its non-animal origin may make it an attractive alternative to present animal-derived surfactants by eliminating the risks of infection and immunogenicity related to the latter." 01/01/2004 - "[Effect of trematoda infection and different concentrations of surface active agents onto physical and chemical characteristics of haemolymph of Planorbarius corneus (Mollusca: Pulmonata)]." 12/01/1994 - "To evaluate the effects of different surfactants on pulmonary infection with group B streptococci in premature rabbits and to examine the effects of different surfactants on pulmonary alveolar macrophage function of newborn rabbits. " 04/01/1964 - "Influence of nonionic surfactants on bacteriophage infections. "

Related Drugs and Biologics

1.	beractant (Survanta)
2.	calfactant
3.	bovine surfactant preparation SF-RI 1
4.	Carbon Monoxide
5.	Exosurf (Exosurf Neonatal)
6.	Edetic Acid (EDTA)
7.	Smear Clear
8.	IgA receptor (protein B)
9.	A 17 (A-17)
10.	Detergents (Detergent)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Artificial Respiration (Mechanical Ventilation)
3.	Catheters
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Lung Transplantation