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Suramin (Suramin Sodium)

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Also Known As:

Suramin Sodium; Germanin; Moranil; Naganin; Naganol; Naphuride; Suramin, Hexasodium Salt; Suramin, Monosodium Salt; Hexasodium Salt Suramin; Monosodium Salt Suramin; Salt Suramin, Hexasodium; Salt Suramin, Monosodium; Sodium, Suramin; 1,3,5-Naphthalenetrisulfonic acid, 8,8'-(carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-

Networked: 749 relevant articles (55 outcomes, 162 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Au, Jessie L-S: 9 articles (01/2015 - 08/2003)
2.	Wientjes, M Guillaume: 9 articles (01/2015 - 08/2003)
3.	Zhuang, Shougang: 6 articles (11/2014 - 02/2009)
4.	Vogelzang, Nicholas J: 6 articles (06/2006 - 07/2002)
5.	Liu, Na: 5 articles (11/2014 - 05/2011)
6.	Schnellmann, Rick G: 5 articles (02/2013 - 02/2009)
7.	Grever, Michael: 4 articles (07/2012 - 08/2003)
8.	Li, Yong: 4 articles (07/2012 - 08/2003)
9.	Fu, Freddie H: 4 articles (07/2012 - 08/2003)
10.	Huard, Johnny: 4 articles (07/2012 - 08/2003)

Related Diseases

1.	Infection 03/01/1994 - "The synergism of DFMO and suramin against an acute infection was improved when suramin was given at the end of the DFMO administration. " 01/01/2015 - "The aim of this study was thus to investigate the antiviral effect of suramin on CHIKV infection and to elucidate the molecular mechanism underlying inhibition using plaque reduction assay, RT-qPCR, western blot analysis, and plaque assay. " 09/01/2015 - "Its approved status makes it worthwhile to explore the use of suramin to prevent and/or treat CHIKV infections. " 01/01/2015 - "Suramin inhibited the early progression of CHIKV infection, due perhaps to interference with virus fusion and binding, which subsequently prevented viral entry. " 01/01/2015 - "Suramin is a symmetric polyanionic naphthylurea that is widely used in the clinical treatment of parasite infections. "
2.	Neoplasms (Cancer) 05/01/2008 - "Suramin therapy resulted in a complete regression of tumor macrovessels and a significant reduction of microvessel density. " 01/01/1999 - "Suramin, a polysulfonated naphthylurea, has been shown to be effective in the treatment of several cancers. " 05/01/1997 - "The results establish that suramin is effective in controlling growth in colonic tumor cells and confirms that suramin activity is synergistic with other chemotherapeutics. " 08/16/2005 - "Although it has shown clinical promise in treatment of several cancers, suramin has many undesirable side effects. " 05/15/1994 - "Because tumor growth is angiogenesis dependent, the clinical efficacy of suramin may relate, in part, to angiosuppression."
3.	Trypanosomiasis 08/01/1989 - "Six of nine goats with cerebral trypanosomiasis induced by this stock were cured by a single high dose of suramin (50 mg kg-1). " 12/01/2014 - "Suramin has been used previously to treat trypanosomiasis in Africa. " 05/01/2011 - "Suramin is a polysulfonated naphthylurea, which was originally synthesized and designed as a treatment for trypanosomiasis and selected malignancies and metastatic diseases. " 10/01/2006 - "The first reported human case of trypanosomiasis caused by Trypanosoma evansi was treated using suramin. " 05/01/1994 - "Suramin is a polysulfonated naphthylurea developed originally to treat trypanosomiasis. "
4.	Fibrosis (Cirrhosis) 11/01/2012 - "Previously, we demonstrated that the anti-fibrotic agent suramin was effective in decreasing fibrosis in mdx muscles. " 09/01/2011 - "In this study, we further assessed the effect of delayed administration of suramin on the progression of tubulointerstitial fibrosis. " 04/05/2014 - "In addition, suramin ameliorated fibrosis and massive hepatic tissue breakdown. " 07/01/2012 - "Suramin treatment initiated at 2 weeks post-injury was observed to promote muscle regeneration and muscle strength, and to decrease fibrosis. " 09/01/2011 - "Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy."
5.	Prostatic Neoplasms (Prostate Cancer) 03/01/2000 - "Androgen deprivation and four courses of fixed-schedule suramin treatment in patients with newly diagnosed metastatic prostate cancer: A Southwest Oncology Group Study." 03/01/1999 - "Recent studies have proved the effect of suramin on prostate cancer. " 01/01/1999 - "In discussions on the utility of suramin our data should be considered as support for continuing the study of suramin in the treatment of advanced, androgen-independent prostate cancer." 11/11/1997 - "Suramin is an experimental antineoplastic agent which is currently being tested in clinical trials for its utility in treating breast and prostate cancer. " 08/01/1997 - "Suramin has demonstrated modest activity against prostate cancer and is being investigated in clinical trials. "

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