Suprofen

01/01/1983 - "All patients reported pain of moderate to very severe intensity upon study enrollment, which improved considerably in 89% of patients by week 1. 12 of the 16 patients reported good to very good pain reduction by week 4. Suprofen was extremely well tolerated by this patient population, and there were no drug-related study withdrawals. "
01/01/1983 - "Suprofen, a new oral peripherally acting analgesic agent, has been shown to be effective in the relief of acute and chronic pain. "
09/01/1986 - "Three separate single-dose studies were performed to evaluate the efficacy of suprofen in acute pain associated with periodontal surgery and removal of impacted third molars. "
12/01/1988 - "Suprofen is a nonsteroidal analgesic with demonstrated efficacy in the treatment of mild to moderate pain associated with a variety of clinical conditions. "
09/01/1986 - "The analgesic efficacy of suprofen in periodontal and oral surgical pain."

06/01/1986 - "The aim of the study was to test the antipyretic effect and the tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) syrup in a sample of pediatric patients with fever of various etiology. "
06/01/1986 - "Antipyretic effect, tolerability, and acceptance of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) drops were tested within the scope of an open study including a total of 111 children with fever of various etiology; two investigational centers participated in this study. "
10/01/1975 - "The antipyretic activity of alpha-methyl--4-(2-thienylcarbonyl)benzeneacetic acid (suprofen) was studied in rats with comparable hyperthermia after s.c. "
10/01/1975 - "The antipyretic effect of suprofen in rats with yeast-induced fever."
06/01/1986 - "Due to its good antipyretic effect and good tolerability, suprofen appears to be particularly useful for symptomatic treatment of pediatric patients with fever caused by bacterial or virus infections."

01/01/1983 - "In a 2-week double-blind study involving 79 patients with mainly osteoarthritis of the hip and knee, Suprofen and Naproxen were compared for efficacy and tolerability in the treatment of the symptoms of the disease. "
01/01/1983 - "Long-term comparison of suprofen and propoxyphene in patients with osteoarthritis."
01/01/1983 - "Long-term clinical evaluation of suprofen and aspirin in patients with osteoarthritis."
01/01/1983 - "43 patients with osteoarthritis of the knee and/or hip(s) were treated with suprofen 800 mg/day or ibuprofen 1,600 mg/day for 14 days. "
07/01/1986 - "In a placebo-controlled double-blind trial analgesic effectiveness and tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) 300 mg suppositories were evaluated for 45 informed patients suffering from chronic pain due to osteoarthritis; the subjects were treated rectally, t.i.d., for 10 days. "

11/01/1991 - "Effects of topical suprofen and flurbiprofen on the miosis produced by anterior chamber irrigation with cholinergic agonists."
01/01/1989 - "Most clinical studies demonstrate a small (0.5-1.0 mm) but significant reduction of surgical miosis by cyclooxygenase inhibitors (COIs), such as indomethacin, flurbiprofen, or suprofen. "
08/01/1992 - "The nonsteroidal antiinflammatory agents (NSAIAs) flurbiprofen and suprofen applied topically to reduce miosis may counteract the desired effects of miotics used during ocular surgery. "
11/01/1991 - "In anterior chambers irrigated with carbachol, suprofen was associated with less miosis than either tears (P = .005) or flurbiprofen (P = .009); however, if the infusion was performed with acetylcholine, no differences between the three groups were noted (P = .44)."
11/01/1991 - "We evaluated the effects of topical suprofen and flurbiprofen on the miosis induced by anterior chamber irrigation with either acetylcholine or carbachol. "

02/01/2007 - "Eleven women with primary dysmenorrhea completed a randomized, double-blind, placebo-controlled, three-way cross-over study comparing 200 and 400mg suprofen. "
01/01/1982 - "These data suggest that suprofen, an analgesic prostaglandin synthetase inhibitor, may be of use in the clinical treatment of uterine contractions associated with primary dysmenorrhea."
02/01/2007 - "Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea."
06/01/1985 - "Taken together with the important role PGF2 alpha plays in the etiology of dysmenorrhea and the observation (Hahn et al., 1982) that suprofen is more potent and effective than a number of other PG synthesis inhibitors, including ibuprofen and aspirin, at reducing in vivo guinea pig uterine contractions induced by arachidonic acid, the results of the present study suggest a mechanism to support the clinical findings that suprofen is a very effective treatment for the signs and symptoms of dysmenorrhea."