Suppositories (Vaginal Suppositories)

Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.

Also Known As:

Networked: 775 relevant articles (77 outcomes, 121 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Karunajeewa, Harin A: 4 articles (04/2007 - 03/2003)
2.	Neĭmark, A I: 3 articles (01/2013 - 07/2011)
3.	Karpukhin, I V: 3 articles (01/2010 - 09/2004)
4.	Fink, Klaus G: 3 articles (01/2010 - 11/2005)
5.	Davis, Timothy M E: 3 articles (04/2007 - 08/2004)
6.	van Gijn, J: 3 articles (09/2006 - 02/2000)
7.	Ilett, Kenneth F: 3 articles (03/2006 - 03/2003)
8.	Ferrari, Anna: 2 articles (11/2015 - 08/2006)
9.	Cohen, Russell D: 2 articles (07/2015 - 10/2006)
10.	Catasús-Álvarez, Karem M: 2 articles (06/2015 - 02/2014)

Related Diseases

1.	Proctitis 10/01/2006 - "Rectally administered 5-ASA and corticosteroid suppositories are effective treatment for most ulcerative proctitis patients. " 12/01/1987 - "5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis." 09/01/1962 - "A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis." 01/01/2015 - "Proctitis could be a complication of stapled hemorrhoidopexy with a good response to conservative treatment with suppositories." 10/01/2006 - "Suppositories should be considered the treatment of choice for proctitis and distal sigmoiditis. "
2.	Pain (Aches) 04/01/1990 - "Conventional fatty-based suppositories have a place in the management of chronic pain but the variability in dissolution and drug absorption limit their usefulness. " 05/23/2006 - "We searched MEDLINE, EMBASE, CENTRAL (up to May 2005) and reference lists for randomized controlled trials of any opioid administered by oral or transdermal routes or rectal suppositories for CNCP (defined as pain for longer than 6 mo). " 01/01/2003 - "Women were less likely to experience pain at or close to 24 hours after birth if they received non-steroidal anti-inflammatory drugs (NSAID) suppositories compared with placebo (relative risk (RR) 0.37, 95% confidence interval (CI) 0.10 to 1.38, 2 trials, 150 women). " 01/01/2003 - "Randomised controlled trials comparing analgesic rectal suppositories with placebo or alternative treatment for the relief of perineal pain. " 03/01/1995 - "Treatment with sCT suppositories caused a statistically significant decrease of pain in both study groups. "
3.	Ulcerative Colitis 01/01/1983 - "In a cross-over trial in 5 patients with ulcerative colitis no difference, was found in the dose-corrected mean (+/- SD) steady state plasma levels (Css) of 5-AS and AcAS between treatment with 5-AS suppositories (0.10 +/- 0.07 and 0.50 +/- 0.20 micrograms/ml, respectively) and SZ (0.12 +/- 0.14 and 0.67 +/- 0.14 micrograms/ml, respectively). " 07/01/1999 - "Practicality of 5-aminosalicylic suppositories for long-term treatment of inactive distal ulcerative colitis." 12/01/2007 - "We recently experienced a case of acute pancreatitis caused by 5-ASA suppositories in a patient with ulcerative colitis. " 04/01/2008 - "Prednisolone suppositories have been used successfully for the treatment of ulcerative colitis in hospital settings. " 04/07/2014 - "Mesalamine suppositories have been used widely for the treatment of distal ulcerative colitis and considered to be safer than systemic administration for its limited systemic absorption. "
4.	Proctocolitis (Hemorrhagic Proctocolitis) 07/01/1990 - "Mesalazine suppositories are safe, well tolerated, and very effective in patients with active distal proctosigmoiditis: 500 mg twice daily appears a suitable dose regimen." 01/01/1990 - "Patient compliance and dramatic response even when conventional therapy has failed make an excellent case for mesalazine suppositories being the treatment of choice for distal ulcerative proctocolitis." 10/01/2002 - "Ulcerative proctitis is treated with 2 x 500 mg or 1 x 1 g suppositories and proctosigmoiditis with 1 to 4 g enemas. " 01/01/1998 - "Mesalamine enemas and suppositories are useful in treating proctosigmoiditis. " 09/01/1990 - "5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosigmoiditis: a double-blind placebo-controlled clinical trial."
5.	Pouchitis 01/01/2000 - "There is no evidence of a difference in the maintenance of symptomatic remission in patients with chronic pouchitis treated with glutamine versus butyrate suppositories, and it is unknown whether glutamine and butyrate are equally effective or ineffective. " 02/01/1999 - "There is no difference in maintenance of symptomatic remission in patients with chronic pouchitis treated with glutamine versus butyrate suppositories, and it is unknown whether glutamine and butyrate are equally effective or ineffective. " 01/01/2000 - "The odds ratio of maintaining remission in chronic pouchitis for oral probiotic bacteria (VSL-3) compared with placebo was 205.00 (95% CI 9.89-4247.71), while the number needed to treat to prevent one additional relapse was 2. After discontinuation of suppressive medical therapy for chronic pouchitis, there was no difference in the odds ratio of maintaining symptomatic remission with glutamine suppositories compared to butyrate suppositories, 3. 00 (95% CI 0.46-19.59). " 02/01/1999 - "There was no difference in the odds ratio of inducing symptomatic remission and then maintaining symptomatic remission after discontinuing suppressive medical therapy for chronic pouchitis with glutamine suppositories compared with butyrate suppositories, 2.75 (95% CI 0.48-15.94). " 10/01/1993 - "Chronic pouchitis after ileal pouch-anal anastomosis: responses to butyrate and glutamine suppositories in a pilot study."

Related Drugs and Biologics

1.	Mesalamine (Mesalazine)
2.	Indomethacin (Indometacin)
3.	Progesterone
4.	Diclofenac (SR 38)
5.	Metronidazole (Metric)
6.	Dinoprostone (PGE2)
7.	Butyrates (Butyrate)
8.	Glutamine (L-Glutamine)
9.	Hydrocortisone (Cortisol)
10.	Bismuth

Related Therapies and Procedures

1.	Enema (Enemas)
2.	Adjuvant Chemotherapy
3.	Ovariectomy (Oophorectomy)
4.	Tonsillectomy
5.	Pessaries