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Sulindac (Copal)

A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Also Known As:
Copal; Clinoril; Aclin; Apo-Sulin; Arthrobid; Arthrocine; Chibret; Kenalin; Klinoril; MK-231; Novo-Sundac; Nu-Sulindac; Sulindal; Apo Sulin; MK 231; MK231; Novo Sundac; Nu Sulindac; 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
Networked: 994 relevant articles (108 outcomes, 234 trials/studies)

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Drug Context: Research Results

Experts

1. Rigas, Basil: 22 articles (07/2021 - 12/2002)
2. Huang, Liqun: 15 articles (07/2021 - 10/2010)
3. Gerner, Eugene W: 14 articles (08/2017 - 01/2006)
4. Piazza, Gary A: 10 articles (01/2020 - 06/2009)
5. Xie, Gang: 10 articles (05/2015 - 10/2010)
6. Giardiello, Francis M: 9 articles (01/2017 - 03/2002)
7. Samadder, N Jewel: 8 articles (05/2022 - 03/2016)
8. Keeton, Adam B: 8 articles (01/2020 - 06/2009)
9. Kopelovich, Levy: 8 articles (02/2015 - 03/2003)
10. Sinicrope, Frank A: 7 articles (10/2020 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Polyps
3. Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
4. Adenoma (Adenomas)
5. Colonic Neoplasms (Colon Cancer)

Related Drugs and Biologics

1. Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
2. Pharmaceutical Preparations
3. Tamoxifen
4. Indomethacin (Indometacin)
5. Aspirin (Acetylsalicylic Acid)
6. Antioxidants
7. Celecoxib (Celebrex)
8. Ibuprofen (Motrin)
9. Naproxen (Naprosyn)
10. Eflornithine (Ornidyl)

Related Therapies and Procedures

1. Therapeutics
2. Colectomy
3. Chemoprevention
4. Drug Therapy (Chemotherapy)
5. Immunotherapy