Sulfhydryl Compounds (Thiols)

03/07/2015 - "Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy."
05/20/2014 - "Most recently, the therapeutic and mechanistic relevance of oxidation of ascorbate and glutathionylation and oxidation of protein thiols by MnP-based SOD mimics and subsequent inactivation of nuclear factor κB has been substantiated in rescuing normal and killing cancer cells. "
01/01/2014 - "Finally, the detection system was employed for sensing intracellular thiols in cancer cells, and the sensing selectivity could be further enhanced with the use of a cancer cell-targeting ligand in the nanoparticles. "
05/10/2013 - "Using UV and FTICR mass spectrometry we also demonstrate for the first time a physical interaction of CuB with NAC and GSH in a cell-free system suggesting that CuB interacts with and modulates cellular thiols to mediate its anti-cancer effects. "
03/20/2013 - "Upon addition of free thiols that are relatively abundant in tumor cells, disulfide bond cleavage occurs as well as active drug GMC release and concomitantly fluorescence intensity increases. "

11/01/1968 - "[On the effect of mercapto-compounds on the course and lethal outcome of novembikhin poisoning in mice of various age group]."
01/01/1961 - "[Action of new sulfhydryl compounds on experimental poisoning by lead triethyl chloride]."
04/01/2007 - "[Experimental study on detoxication effect of sulfhydryl compounds in acute poisoning of dimethylformamide]."
03/21/2011 - "The results of Pd scavenging and catalyst poisoning by elemental analysis (EA) and transmission electron microscopy (TEM) indicate that silica-bound thiols have an advantage over resin-bound thiols in residual Pd removal from a Heck reaction solution and that all of these scavengers poison effectively the catalytic species but hardly scavenge Pd clusters, even as small as 1 nm from solution presumably because of the steric barrier. "
05/17/1971 - "[Action of several thiols on experimental poisoning by dibutyl lead diacetate in rats]."

07/01/2014 - "Furthermore, significant and progressive oxidation of "buried" protein thiols in CSF of TBI patients (compared to those of nontrauma controls) was detected over a 24-h period after hospital admission, with increased oxidation correlating with severity of trauma. "
02/01/1984 - "These effects are determined by the radiation-chemical mechanism, the toxic effect of recovery products, a decrease in the content of nonprotein sulfhydryl compounds, the suppression of cell regeneration resulting from lethal injuries. "
10/01/2011 - "In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds."
01/01/2014 - "Extracellular thiols and human serum also significantly reduce the antimicrobial activity of silver wound dressings Aquacel-Ag (Convatec) and Acticoat (Smith & Nephew) to Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli in vitro. "
10/01/2011 - "Bismuth thiols are effective antimicrobial agents against biofilms formed by wound bacteria and merit further development as topical antiseptics for the suppression of biofilms in chronic wounds."

01/01/2012 - "A significant reduction (p<0.05) of intracellular total thiols and a significant loss (p<0.01) of glycophorin A, band 3 and CD47 was found in red blood cells from patients with limited cutaneous sclerosis. "

01/01/2012 - "Imexon also reacts with thiols and it is especially potent against multiple myeloma in cell cultures. "