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Sulfaphenazole

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A sulfonilamide anti-infective agent.

Also Known As:

Sulphaphenazole; Phenylsulfapyrazole; Sulfaphenylpyrazol; Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-

Networked: 25 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ishihara, Yasuhiro: 4 articles (01/2012 - 06/2009)
2.	Shimamoto, Norio: 3 articles (01/2012 - 06/2009)
3.	Fleming, Ingrid: 3 articles (03/2008 - 01/2004)
4.	Taddei, Stefano: 2 articles (02/2010 - 03/2009)
5.	Giannarelli, Chiara: 2 articles (02/2010 - 03/2009)
6.	Virdis, Agostino: 2 articles (02/2010 - 03/2009)
7.	Nakazawa, Mikio: 2 articles (01/2010 - 06/2009)
8.	Sekine, Masaya: 2 articles (01/2010 - 06/2009)
9.	Kuppusamy, Periannan: 2 articles (04/2009 - 12/2007)
10.	Khan, Mahmood: 2 articles (04/2009 - 12/2007)

Related Diseases

1.	Ischemia 01/01/2012 - "Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa." 10/01/2005 - "Rat hearts were perfused in the Langendorff mode for 20 min in the presence, or absence, of sulfaphenazole and then subjected to 30 min global no-flow ischemia followed by 15 min reperfusion. " 02/01/2010 - "Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia-reperfusion (I/R) injury (Ref. " 01/01/2012 - "We previously reported the administration of a potent cytochrome P450 inhibitor, sulfaphenazole (SPZ), to suppress oxidative stress and the extension of myocardial infarct size in a rat model of cardiac ischemia-reperfusion (I/R). "
2.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/1980 - "Efficacy of hemodialysis and the effects of certain displacing agents on plasma protein binding of sulfamethoxazole and sulfaphenazole in patients with chronic renal failure."
3.	Myocardial Infarction 04/01/2009 - "The objective of this study was to establish the cardioprotective effect of sulfaphenazole (SPZ), a selective inhibitor of cytochrome P450 2C9 enzyme, in an in vivo rat model of acute myocardial infarction (MI). " 01/01/2012 - "We previously reported the administration of a potent cytochrome P450 inhibitor, sulfaphenazole (SPZ), to suppress oxidative stress and the extension of myocardial infarct size in a rat model of cardiac ischemia-reperfusion (I/R). "
4.	Leprosy (Hansen's Disease) 10/01/1961 - "Trial of a long-acting sulfonamide sulfaphenazole (Orisul, Ciba), in the treatment of leprosy."
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2008 - "In this study, we focus on the contribution of monooxygenase enzyme-generated reactive oxygen species in vascular dysfunction in an experimental model of diabetes mellitus type II. Diabetic male mice (db/db strain) and their age-matched controls received daily intraperitoneal injections of either the CYP 2C inhibitor sulfaphenazole (5.13 mg/kg) or saline (vehicle control) for 8 weeks. "

Related Drugs and Biologics

1.	Sulfamethoxazole
2.	Cytochromes
3.	Carrier Proteins (Binding Protein)
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Acetylcholine (Acetylcholine Chloride)
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	omega-N-Methylarginine (NG Monomethyl L Arginine)
10.	Collagenases (Collagenase)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Intraperitoneal Injections