Sulfamethoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Also Known As:

Networked: 1041 relevant articles (102 outcomes, 84 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Park, B Kevin: 11 articles (06/2011 - 09/2002)
2.	Naisbitt, Dean J: 9 articles (06/2011 - 09/2002)
3.	Trepanier, Lauren A: 6 articles (04/2011 - 08/2004)
4.	Pirmohamed, Munir: 6 articles (04/2009 - 09/2002)
5.	Farrell, John: 5 articles (06/2011 - 09/2002)
6.	Lavergne, Sidonie N: 5 articles (06/2011 - 03/2005)
7.	Naisbitt, D J: 4 articles (08/2015 - 12/2000)
8.	Vilar, F Javier: 4 articles (04/2009 - 02/2003)
9.	Norose, Kazumi: 3 articles (02/2016 - 01/2004)
10.	Yano, Akihiko: 3 articles (02/2016 - 01/2004)

Related Diseases

1.	Infection 10/01/2013 - "Trimethoprime-sulfamethoxazole and carbapenem are the first line treatment for infections related to S. " 07/01/1967 - "[Clinical study of Ro 4-4309 (uro-gantanol) in infection of the kidney and urinary tract]." 05/01/2013 - "Sulfamethoxazole (SMX), a sulfonamide commonly used to treat urinary infections, is one of them. " 10/01/2008 - "Organ dysfunction is the only independent risk factor associated with death from infection caused by sulfamethoxazole-resistant S. " 03/01/2008 - "trimethoprime-sulfamethoxazole prophylaxis is widely used to prevent Pneumocystis jiroveci infection in children with haematologic malignancies. "
2.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2014 - "The present study aimed to assess the antibiotic resistance profiles and detect the presence of the sul2 gene in sulfamethoxazole-susceptible and resistant isolates of Escherichia coli obtained from outpatients and inpatients with urinary tract infections. " 04/20/1974 - "Complete disappearance of urinary tract infection was obtained in 82% of subjects treated with the combination versus 59% in those treated with sulfamethoxazole alone. " 09/01/1969 - "Sulfamethoxazole suspension in acute urinary tract infection in children." 03/01/1962 - "Clinical results with Gantanol in severe urinary tract infections." 01/02/1971 - "The use of trimethoprim and sulphamethoxazole in the management of chronic and recurrent upper and lower urinary tract infection."
3.	Pneumonia (Pneumonitis) 07/01/2002 - "farcinica pneumonia in Japan, and the measurement of the concentration of sulfamethoxazole was useful to determine its dosage." 11/01/2014 - "The pneumonia resolved with sulfamethoxazole and steroid pulse therapy, and cystitis subsided spontaneously. " 02/01/1990 - "He suffered from pneumonia with marked improvement on sulfamethoxazole-Trimethoprim. " 01/01/2009 - "Good outcome with trimethoprim 10 mg/kg/day-sulfamethoxazole 50 mg/kg/day for Pneumocystis jirovecii pneumonia in HIV infected patients." 03/01/1974 - "A combination of trimethoprim and sulfamethoxazole was effective in the prevention and treatment of Pneumocystis carinii pneumonitis in cortisonetreated rats. "
4.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/01/1996 - "Adverse cutaneous reactions frequently occur during the treatment of AIDS associated pneumocystosis by trimethoprime-sulfamethoxazole. " 04/01/2008 - "Although two patients had grade 3 or 4 pulmonary toxicity due to Pneumocystis carinii pneumonia, these patients recovered after receiving trimetoprim-sulfamethoxazole, steroid therapy, and supplemental oxygen. " 04/01/1998 - "Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. " 01/01/2010 - "The patient was diagnosed with pneumocystis pneumonia, which was successfully treated with sulfamethoxazole trimethoprim; the reversed halo sign disappeared, leaving cystic lesions. " 01/27/1995 - "As Pneumocystis carinii pneumonia was suspected but bronchoscopy was too risky, he was at first treated with trimethoprim/sulphamethoxazole (four times 320/1600 mg/24 h intravenously). "
5.	Wegener Granulomatosis (Wegener's Granulomatosis) 08/01/1991 - "This experience suggests that sulfamethoxazole-trimethoprim may be an effective treatment for some patients with Wegener's granulomatosis and may be the only agent required. " 02/01/2003 - "Trimethoprim-sulphamethoxazole for the treatment of Wegener's granulomatosis." 05/01/2002 - "Sulphamethoxazole-trimethoprim in the treatment of limited paranasal Wegener's granulomatosis." 07/01/2001 - "Trimethoprim-sulphamethoxazole has been used in limited Wegener's granulomatosis. " 07/01/2001 - "Generalized Wegener's granulomatosis responding to sulfamethoxazole-trimethoprim monotherapy."

Related Drugs and Biologics

1.	Trimethoprim (Proloprim)
2.	Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)
3.	Ampicillin (Omnipen)
4.	Thymidine Monophosphate (TMP)
5.	Prednisolone (Predate)
6.	Chloramphenicol (Chloromycetin)
7.	Amoxicillin (Wymox)
8.	Tetracycline (Achromycin)
9.	Pentamidine (NebuPent)
10.	Norfloxacin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Oral Administration
5.	Renal Dialysis (Hemodialysis)